Gianluca Tamagno, Gadintshware Gaoatswe
Encephalopathy associated with autoimmune thyroid disease is a rare condition presenting in the setting of autoimmune thyroid disease and characterized by unspecific neurological and/or psychiatric symptoms. Bearing in mind the currently prevailing lack of consensus on the most appropriate nomenclature and diagnostic criteria for this condition and the implications …
Eva N. Kassi, Spiros Stavropoulos, Panayiotis Kokkoris, Antonis Galanos, Paraskevi Moutsatsou, Cleanthi Dimas, Athanasios Papatheodorou, Christos Zafeiris, George Lyritis
OBJECTIVE: We aimed to determine the prevalence of 25(OH)D (D2 and D3 independently) inadequacy in healthy young/middle-aged men and to investigate its relationship with BMD, bone markers, demographic and lifestyle parameters such as age, BMI, smoking, alcohol consumption and dietary calcium intake …
Theodore K. Alexandrides, Konstantina Kouloubi, Apostolos G. Vagenakis, Spyros Yarmenitis, Trifon Spyridonidis, Pavlos Vassilakos, Dimitris Apostolopoulos
Parathyroid scintigraphy and high-resolution ultrasonography are frequently used as preoperative localization procedures in primary hyperparathyroidism. However, when thyroid disease coexists, their diagnostic accuracy is probably abated. DESIGN: 56 patients with primary hyperparathyroidism were prospectively evaluated with parathyroid scintigraphy…
Eleni Kousta, Natasha J. Lawrence, Ian F. Godsland, Anna Penny, Victor Anyaoku, Barbara A. Millauer, Stephen Robinson, Desmond G. Johnston, Mark I. McCarthy
OBJECTIVE: To characterise early metabolic abnormalities and the impact of ethnicity following gestational diabetes mellitus (GDM). DESIGN: Women with a history of GDM belonging to three different ethnic groups were evaluated. Using the insulin-modified, frequently-sampled intravenous glucose tolerance test (FSIVGTT) and HOMA we studied 34 European …
Anna-Maria Touvra, Konstantinos A. Volaklis, Apostolos T. Spassis, Christos E. Zois, Helen T. Douda, Kalliopi Kotsa, Savvas P. Tokmakidis
OBJECTIVE: The aim of the present study was to examine the effects of a combined strength and aerobic training program on pro- and anti-inflammatory cytokines and transforming growth factor-β1 in patients with type 2 diabetes. DESIGN: Ten patients with type 2 diabetes, aged 55.5 (5) years [median (IQR)] participated in a supervised systematic exercise training program …
Alexandra Chrisoulidou, Maria Boudina, Niki Karavitaki, Eleni Bili, John Wass
The pituitary gland is significantly affected during gestation in terms of both size and function. Due to this physiologic adaptation, endocrine evaluation and interpretation of imaging is far more complex than in the non-pregnant state. Pituitary disorders are rare in pregnancy, as they are usually associated with gonadal dysfunction …
Constantine A. Stratakis
In the mid 1980’s, two advances revolutionized Medicine in a way that is comparable only to some of the most important events in the approximately 3,000 years of its history. The first was the introduction of the concept of “positional cloning”, i.e. the idea that one can identify genes for human disease though knowing nothing or very little about their function…
Evanthia Diamanti-Kandarakis, Charikleia D. Christakou, Eleni Kandaraki, Krystallenia I. Alexandraki
Polycystic Ovary Syndrome is a heterogenous syndrome of unknown causation commonly associated with obesity. Τhe particular timing of the onset of obesity may be important, since the earlier the onset of obesity the greater the severity of the metabolic and hormonal aberrations …
Guilherme Rosa, Estelio H.M. Dantas, Danielli Braga de Mello
OBJECTIVE: To investigate the effects of concurrent training (CT) on serum leptin, cortisol and zinc concentrations in physically active adults. DESIGN: Ten subjects aged (27.1±4.8 years, BMI 25.49 ± 2.65) were recruited to participate in three sessions: control session (CS), concurrent training 1 (CT1) and concurrent training 2 (CT2) sessions with five days of resting between them. In each session blood samples for leptin …
Caleb Hersh, Julia Sisti, Vincent Richiutti, Eva Schernhammer
OBJECTIVE: The circadian hormone melatonin has wide-reaching effects on human physiology. In adolescents, the impact of nighttime light exposure and other modifiable behavioral factors on melatonin levels is poorly understood. DESIGN: We cross-sectionally examined the influence of nighttime behaviors …
Vassiliki Syriou, Asimina Kolitsa, Lamprini Pantazi, Dimitrios Pikazis
A 47-year old man with idiopathic hypoparathyroidism (IHP), presented as severe myopathy and skin rash is described. The serum muscle enzymes were increased. After treatment with calcium and vitamin D, the clinical condition improved, the skin rash gradually disappeared, and the muscle enzymes decreased and remained within the normal range thereafter.
Massimo Giusti, Francesca Cecoli, Carla Ghiara, Alessandro Rubinacci, Isabella Villa, Domenico Cavallero, Laura Mazzuoli, Michele Mussap, Roberto Lanzi, Francesco Minuto
OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), such as an in vitro action on bone, have been described. Our aim was to evaluate in vivo the acute effect of a recombinant human TSH (rhTSH)-induced TSH surge on Osteoprotegerin (OPG) and receptor activator of the nuclear factor-κB (RANK-L) levels in patients under levo-thyroxine (L-T4) therapy…
Stathopoulos P. Ioannis, Liakou G. Chrysoula, Katsalira Aikaterini, Trovas George, Lyritis P. George, Papaioannou A. Nikolaos, Tournis Symeon
OBJECTIVE: The unique pharmacokinetics of bisphosphonates (BPs) in conjunction with their use by an increasing number of women at reproductive age has raised serious concerns about their safety during pregnancy and lactation. Bisphosphonates cross the placenta. Animal studies have shown adverse effects on both the fetus and the mother …
Thomas JG. Chambers, Richard A. Anderson
Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function, including DNA fragmentation …
Valentin V. Fadeyev, Tatiana B. Morgunova, Julia P. Sytch, Galina A. Melnichenko
The aim of this study was to evaluate parameters of thyroid function in patients with primary hypothyroidism receiving either monotherapy with L-T4 or combination L-T4+L-T3. Fifty-eight women with primary hypothyroidism receiving L-T4 were enrolled in the study. The patients were randomised into two groups: Group 1 (n=42) patients continued monotherapy with L-T4, and Group 2 …
Robin P. Peeters
With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly…
Neoklis A. Georgopoulos, Anastasia Theodoropoulou, Nikolaos D. Roupas, Loredana Rottstein, Athanasios Tsekouras, Panagiotis Mylonas, George A. Vagenakis, Eftychia Koukkou, Anastasia K. Armeni, George Sakellaropoulos, Michel Leglise, Apostolos G. Vagenakis, Kostas B. Markou
PURPOSE: The aim of this study was to determine the impact of intensive training on adult final height in elite female rhythmic and artistic gymnasts. METHODS: The study included 215 rhythmic gymnasts (RG) and 113 artistic gymnasts (AG) …
Nicolas C. Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, Evangelia Charmandari
Primary Generalized Glucocorticoid Resistance is a rare condition characterized by generalized, partial, target tissue insensitivity to glucocorticoids owing to inactivating mutations, insertions or deletions in the human glucocorticoid receptor (hGR) gene (NR3C1). Recent advances in molecular and structural biology have enabled us to elucidate the molecular mechanisms of action of the mutant receptors and to understand how certain conformational alterations …
Acromite Michael, Ziotopoulou Mary, Orlova Christine, Mantzoros Christos
Leptin is secreted mainly by the white adipose tissue but is also synthesized in several non-adipose tissue organs including the placenta. Serum leptin levels are increased in normal pregnancies and are higher in preeclamptic than normal pregnant women. There is, however, a lack of empirical evidence of an independent association of serum leptin levels and preeclamsia …
Roberta Giordano, Lorenza Bonelli, Elisa Marinazzo, Ezio Ghigo, Emanuela Arvat
This paper will focus on the rationale of using Growth Hormone (GH) as an anti-ageing therapy in the healthy elderly with age-related decline in the activity of the GH/IGF-I axis, the so called “somatopause”. Although the age-related decline in the activity of the GH/IGF-I axis is considered to contribute to age-related changes …
Spiridon Dimas, Spiridon Michas, Ioannis Christakis, Christos Augoustis, Maria Alevizaki
OBJECTIVE: Previous neck surgery (PNS) in patients with primary hyperparathyroidism (PHP) is considered as a contraindication for minimally invasive parathyroidectomy (MIP). The purpose of our study was to determine the effectiveness of MIP in such patients …
Manuela Götzberger, Susanne Krueger, Roland Gärtner, Martin Reincke, Matthias Pichler, Gerald Assmann, Thomas Mussack, Michael Zimmermann, Veit Gülberg
OBJECTIVE: Strain-elastography provides a new ultrasound-based method that can offer information about the stiffness of thyroid nodules as an indicator of malignancy. The aim of our study was to compare the utility of color-Doppler and strain-elastography in differentiating between benign and malignant nodules. DESIGN AND METHODS: 77 thyroid nodules (70 benign and 7 malignant) from 70 unselected patients (48 female/22 male, mean age 49.7±14.3 years) were evaluated with color-Doppler …
Marios C Lazanas, Irene V Lambrinoudaki, Gerasimos A Douskas, Georgios A Tsekes, Maria N Chini, Evangelos K Georgiou
Data on body composition changes in HIV infected patients is sparse and controversial. The aim of this study was to assess body composition in asymptomatic HIV-infected men with normal body weight in comparison to healthy HIV-negative control men and to investigate possible body composition changes …
Nikolaos Vitoratos, Georgios Valsamakis, George Mastorakos, Anastassios Boutsiadis, Nikolaos Salakos, Evagelia Kouskouni, George Creatsas
OBJECTIVE: To investigate maternal serum adiponectin and Ιnterleukin-1beta (IL-1β) levels during the pre- and post-partum periods in pregnant women with and without Gestational Diabetes Mellitus (GDM). DESIGN: Thirty control pregnant Caucasian women without GDM and thirty Body Mass Index (BMI) and age-matched Caucasian women with GDM examined in the outpatient clinic between …
Themistoklis N. Spyridopoulos, Nick Dessypris, Antonis G. Antoniadis, Spyros Gialamas, Constantine N. Antonopoulos, Konstantina Katsifoti, Hans-Olov Adami, George P. Chrousos, Eleni Th. Petridou, and the Obesity and Cancer Oncology Group
OBJECTIVE: Obesity and diabetes are considered risk factors for Renal Cell Carcinoma (RCC). We aimed to explore whether insulin resistance (IR) plays an independent role in the development of RCC. DESIGN: In a hospital-based case-control study, we analyzed serum glucose …