Vera Popovic, Felipe F. Casanueva
Recent data suggest that in addition to leptin’s role in conveying signals of the amount of energy stores to the central nervous system, this adipocyte secreted hormone interacts with the endocrine system to provide critical information about the size of fat stores, acting as a permissive factor that allows the triggering of energy demanding situations …
Antje Körner, Susann Blüher, Thomas Kapellen, Ante Garten, Jürgen Klammt, Jürgen Kratzsch, Wieland Kiess
Body weight is regulated by a feedback loop in which peripheral signals report nutritional information to an integratory center in the brain. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centered in the hypothalamus…
Dafni-Kalliopi Papafragkaki, George Tolis
Obesity is one of the most frequently encountered medical problems of our time. Among the complications of this pathologic entity, renal disease is an important issue and its pathophysiologic mechanisms are a challenge for the physician, since a variety of etiologic factors are implicated in its genesis. For example, hypertension, hyperlipidemia and insulin resistance …
Arash Babaei, Sayyed Hamid Zarkesh-Esfahani, Ehsan Bahrami, Richard J. Ross
Leptin, the adipocyte derived hormone, has a pivotal role in regulating energy homeostasis and appetite. Beyond this essential role in bodyweight control, leptin also regulates the immune responses. Leptin has pro-inflammatory effects on T cell populations, shifting the T helper balance towards a TH1 phenotype, through induction of pro-inflammatory cytokines and stimulation …
Charilaos Stylianou, Assimina Galli-Tsinopoulou, Dimitrios Farmakiotis, Israel Rousso, Michael Karamouzis, George Koliakos, Sanda Nousia-Arvanitakis
OBJECTIVE: Ghrelin and leptin levels are influenced by body fat (BF%), pubertal stage and possibly insulin resistance (IR). The aim of our study was: 1) To compare fasting ghrelin and leptin levels between obese and non-obese, adolescents, 2) to investigate possible correlations of these hormones with BF %, as well as IR…
Acromite Michael, Ziotopoulou Mary, Orlova Christine, Mantzoros Christos
Leptin is secreted mainly by the white adipose tissue but is also synthesized in several non-adipose tissue organs including the placenta. Serum leptin levels are increased in normal pregnancies and are higher in preeclamptic than normal pregnant women. There is, however, a lack of empirical evidence of an independent association of serum leptin levels and preeclamsia …
Adeela Shahid, Khalid P. Lone, Sadia Saeed, Muhammad Arslan
OBJECTIVE: We studied the influence of positive family history (FH) of type 2 diabetes mellitus (T2DM) in male offspring using multiple metabolic and endocrine parameters in order to assess whether one or more of these parameters can be used as indicators for T2DM development later in life. DESIGN: Fifty male subjects with one diabetic parent (ODP) and thirty with both diabetic parents …
Themistoklis N. Spyridopoulos, Eleni Th. Petridou, Nick Dessypris, Agapios Terzidis, Alkistis Skalkidou, Charalambos Deliveliotis, George P. Chrousos and the Obesity and Cancer Oncology Group*
OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity. Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk …
Guilherme Rosa, Estelio H.M. Dantas, Danielli Braga de Mello
OBJECTIVE: To investigate the effects of concurrent training (CT) on serum leptin, cortisol and zinc concentrations in physically active adults. DESIGN: Ten subjects aged (27.1±4.8 years, BMI 25.49 ± 2.65) were recruited to participate in three sessions: control session (CS), concurrent training 1 (CT1) and concurrent training 2 (CT2) sessions with five days of resting between them. In each session blood samples for leptin …
Themistoklis N. Spyridopoulos, Nick Dessypris, Antonis G. Antoniadis, Spyros Gialamas, Constantine N. Antonopoulos, Konstantina Katsifoti, Hans-Olov Adami, George P. Chrousos, Eleni Th. Petridou, and the Obesity and Cancer Oncology Group
OBJECTIVE: Obesity and diabetes are considered risk factors for Renal Cell Carcinoma (RCC). We aimed to explore whether insulin resistance (IR) plays an independent role in the development of RCC. DESIGN: In a hospital-based case-control study, we analyzed serum glucose …
Ghollam-Reza Moshtaghi-Kashanian, Fakhrolmulok Razavi
OBJECTIVE: Recently published animal studies indicate that leptin and ghrelin play a role in puberty initiation and progress as well as in reproduction. The aim of our study was to evaluate the relation of these two hormones to the pubertal maturity and fertility status in patients with β-thalassemia …
Nikolaos D. Roupas, Irene Mamali, Spyros Maragkos, Lydia Leonidou, Anastasia K. Armeni, George K. Markantes, Athanasios Tsekouras, George C. Sakellaropoulos, Kostas B. Markou, Neoklis A. Georgopoulos
OBJECTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners …