Targeting the osteoblast: approved and experimental anabolic agents for the treatment of osteoporosis

Konstantinos A. Toulis, Athanasios D. Anastasilakis, Stergios A. Polyzos, Polyzois Makras

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Targeting osteoblast may be the means of effectively improving both bone quality and mass, thus offering an intriguing alternative in the treatment of osteoporosis. Aside from injectable parathyroid hormone (PTH) and its novel preparations, PTH-related peptide (PTHrP), calcilytics …

Sexual dysfunction in diabetic women

Alexandra Bargiota, Konstantinos Dimitropoulos, Vassilios Tzortzis,, Georgios N. Koukoulis

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Diabetes mellitus (DM) is a common disease worldwide and a growing public health burden. The number of people with diabetes is increasing due to population growth, aging, urbanization, and increasing prevalence of obesity and physical inactivity. Diabetes is known to cause multiple medical …

Epidemiological characteristics of children with autoimmune thyroid disease

Vasiliki Skarpa, Eleni Κousta, Athanasia Tertipi, Konstantinos Anyfandakis, Marina Vakaki, Maria Dolianiti, Aspasia Fotinou, Asteroula Papathanasiou

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OBSECTIVE: Chronic autoimmune thyroiditis (AT) is the most common cause of thyroid disease in children. The aim of the study was to define the epidemiological clinical and laboratory characteristics of children and adolescents with AT. DESIGN: Various parameters including thyroid ultrasonography of 228 children and adolescents …

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Guilherme Rosa, Estelio H.M. Dantas, Danielli Braga de Mello

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OBJECTIVE: To investigate the effects of concurrent training (CT) on serum leptin, cortisol and zinc concentrations in physically active adults. DESIGN: Ten subjects aged (27.1±4.8 years, BMI 25.49 ± 2.65) were recruited to participate in three sessions: control session (CS), concurrent training 1 (CT1) and concurrent training 2 (CT2) sessions with five days of resting between them. In each session blood samples for leptin …

Cushing’s disease: Results of treatment and factors affecting outcome

Ariachery C. Ammini, Saptarshi Bhattacharya, Jaya Praksh Sahoo, Jim Philip, Nikhil Tandon, Ravinder Goswami, Viveka P. Jyotsna, Rajesh Khadgawat, Sunil Chumber, Aashu Seth, Asis K. Karak, Bhawani S. Sharma, Poodipedi Sarat Chandra, Ashish Suri, Manish S. Sharma, Shashank S. Kale, Manmohan Singh

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OBJECTIVE: To analyze the therapeutic results of intervention and the factors affecting the outcome of patients with Cushing’s disease (CD) cared for at the All Indian Institute of Medical Science (AIIMS), New Delhi. DESIGN. Patients with Cushing’s disease treated at a teritiary care centre from January 2000 to December 2009 were prospectively studied …

Late diagnosis of 5alpha steroid-reductase deficiency due to IVS12A>G mutation of the SRD5a2 gene in an adolescent girl presented with primary amenorrhea

Nicos Skordis, Christos Shammas, Elisavet Efstathiou, Amalia Sertedaki, Vassos Neocleous, Leonidas Phylactou

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BACKGROUND: The clinical spectrum of 5α-reductase deficiency, caused by mutations in the SRD5A2 gene, ranges from complete female appearance of the external genitalia at birth to nearly complete male phenotype. CASE REPORT: A 14-year-old girl presented with primary amenorrhea (PA) and lack of breast development …

Growth Hormone Deficiency: an unusual presentation of Floating Harbor Syndrome

Assimina Galli-Tsinopoulou, Ioannis Kyrgios, Eleftheria Emmanouilidou, Ioanna Maggana, Eleni Kotanidou, Paraskevi Kokka, Charilaos Stylianou

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Floating-Harbor Syndrome (FHS) is a very rare condition of unknown etiology characterized by short stature, delayed bone age, characteristic facial features, delayed language skills and usually normal motor development …

Obesity in the paleolithic era

Laszlo G. Jozsa

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Photos and/or copies of one hundred Upper Paleolithic (45,000-40,000 to 10,000 BP) statues were studied, the photos having been taken from the frontal, lateral and back view. Among the 97 female idols studied, 24 were skinny (mainly young women), 15 were of normal weight, while more than half of them (51) represented overweight or very obese females whose breasts were also extremely large …