Andrew (Andy) N. Margioris
With this first issue of HORMONES for 2013, we celebrate 12 years of continuous publication. The Journal HORMONES has been listed in Pubmed since 2005 and its current impact factor is 2.4 …
Journal Articles
Growth Management of Children and Adolescents with Cushing’s Disease
In this issue, Savage et al., summarize and discuss their data and those of the literature on the growth management of pediatric patients with Cushing’s disease. Endogenous Cushing’s syndrome is rare in all ages and children and adolescents represent about 10 percent of the total …
Muscular effects of vitamin D in young athletes and non-athletes and in the elderly
Nikolaos E. Koundourakis, Pavlina D. Avgoustinaki, Niki Malliaraki, Andrew N. Margioris
Muscles are major targets of vitamin D. Exposure of skeletal muscles to vitamin D induces the expression of multiple myogenic transcription factors enhancing muscle cell proliferation and differentiation. At the same time vitamin D suppresses the expression of myostatin, a negative regulator of muscle mass …
Adrenal Incidentalomas or Adrenalomas: The NIH state-of-the-science conference statement
Editorial
In this issue of Hormones, Dr. Dimitrios Linos has written a comprehensive review on adrenal incidentalomas, for which he proposes the more economical term “adrenalomas”. The management of these incidentally discovered, common masses has many controversies stemming from the fact that a minute proportion of them can be malignant …
Data Mining: A New Technique In Medical Research
Eirini Papageorgiou, Ioanna Kotsioni, Athena Linos
This issue hosts an article that discusses the application of Data mining techniques to the treatment of infertile men with azoospermia, and compares this procedure of categorisation into groups with the corresponding clinical categorisation…
Wylie Walker Vale, Jr.
George P. Chrousos, Achille Gravanis, Andrew (Andy) N. Margioris
Wylie Walker Vale, Jr. was born in Houston, Texas, on July 3, 1941. While still in high school, he met and fell in love with his wife Betty to whom he was married for over 40 years. Wylie earned his bachelor’s degree in Biology …
Expression of somatostatin receptors may guide the use of somatostatin receptor imaging and therapy in differentiated thyroid cancer
Giorgio Treglia, Guido Rindi, Vittoria Rufini
Thyroid carcinoma is the most frequent type of endocrine tumour. Most differentiated thyroid cancers (DTCs) have an excellent prognosis if diagnosed early and treated appropriately. Nevertheless, a number of patients with DTCs do not achieve remission after thyroidectomy …
Normocalcemic primary hyperparathyroidism: A newly emerging disease needing therapeutic intervention
Gonzalo Díaz-Soto, María Teresa Julián, Manel Puig-Domingo
Normocalcemic primary hyperparathyroidism (NCHPT) is a new entity which possibly represents a “fruste form” of classic clinically symptomatic hyperparathyroidism. Over the last decade it has generated considerable scientific interest …
Editor’s Note
Andrew N. Margioris
From the Editor
Andrew N. Margioris
We welcome you to the 2013 third trimester issue of Hormones! In this issue, the Reviews section includes four papers …
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
Cláudia Nogueira, Selma B. Souto, Eduardo Vinha, Daniel Carvalho-Braga, Davide Carvalho
Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy …
Hoarseness after thyroidectomy: Blame the endocrine surgeon alone?
Demetrios Moris, Eleftherios Mantonakis, Marinos Makris, Adamantios Michalinos, Spiridon Vernadakis
OBJECTIVE: Hoarseness is a postoperative complication of thyroidectomy, mostly due to damage to the recurrent laryngeal nerve (RLN). Hoarseness may also be brought about via vocal cord dysfunction (VCD) due to injury of the vocal cords from manipulations during anesthesia, as well as from psychogenic disorders …
Comments on gestational diabetes mellitus: from pathophysiology to clinical practice
Pavlos Poulakos, Gesthimani Mintziori, Efrosini Tsirou, Eleftheria Taousani, Dimitra Savvaki, Vikentia Harizopoulou, Dimitrios G. Goulis
Gestational diabetes mellitus (GDM) is a topic of major interest, as it affects up to 16% of pregnant women and may lead to adverse pregnancy outcomes, which, however, are preventable by appropriate treatment. The aim of the present study was to discuss basic concepts and to critically appraise recent updates on practical issues …
Liquid levothyroxine and its potential use
Anna Maria Formenti, Linda Daffini, Ilenia Pirola, Elena Gandossi, Alessandra Cristiano, Carlo Cappelli
Editorial
Aleksander Giwercman, Dimitrios G. Goulis, Ilpo Huhtaniemi, Christos Tsatsanis
This issue of HORMONES is dedicated to the Symposium “Endocrine Aspects in Andrology” that took place in Heraklion, Crete, Greece, on 13-15 March, 2015 …
Letter from the Editor
C. Dacou-Voutetakis
Dear Colleague, “HORMONES”, the new peer reviewed International Journal of Endocrinology and Metabolism, has finally been born. Every creation is marked by birth followed by growth and maturation, and we hope that our Journal will follow these evolutionary steps…
Macroprolactinemia: an unnoticeable factor
Hyperprolactinemia most commonly results from physiologic or pathologic conditions that cause hypersecretion of PRL by lactotroph cells. Physiologic causes include pregnancy and lactation while pathologic hyperprolactinemia may result from a lactotroph adenoma or from several readily identifiable causes that may interfere with normal dopamine inhibition of PRL secretion. However, in some patients whose serum PRL …
Genetic Testing in Clinical Endocrinology
Constantin Polychronakos
For the past several decades, the standard diagnostic and clinical research tool in endocrinology has been the hormone assay. The enormous surge in the development and use of molecular and cell biology technologies in the past two decades has advanced our understanding of hormone synthesis, secretion, regulation and action at the cellular level but had a relatively modest impact on the exploration of hormonal physiology …
Adrenal incidentaloma: a diagnostic challenge
Panagiotis Anagnostis, Asterios Karagiannis, Konstantinos Tziomalos, Anna I. Kakafika, Vasilios G. Athyros, Dimitri P. Mikhailidis
The widespread application of abdominal imaging procedures has resulted in an increased frequency of clinically silent adrenal masses. Adrenal incidentaloma (AI) is a term applied to an accidentally discovered adrenal mass on imaging performed for the investigation of an unrelated complaint …
Lessons derived from studies in the elderly: the role of nutrition education in cardiovascular disease prevention
Demosthenes B. Panagiotakos
Based on statistics from the World Health Organization (WHO), the proportion of people over the age of 60 years is growing faster than any other age-group and, in many countries, it is the fastest growing segment of the population …
Pituitary Hyperplasia
Mubarak Al-Gahtany, Eva Horvath, Kalman Kovacs
Pituitary hyperplasia is rare, difficult to diagnose and sometimes controversial. The hyperplasia could be physiologic which is usually reversible, or pathologic which varies in presentation from incidental to tumor like lesion with and without hormonal disturbance. Any pituitary cell is capable of undergoing hyperplasia in the presence of the right stimuli …
Where postmenopausal hormone therapy stands today
Amos Pines
A dramatic change has occurred over the past decade with regard to the use of hormones during the postmenopausal period. In the 90’s, the belief in the USA being that there was reason to recommend hormone therapy (HT) for the prevention of coronary artery disease, the guidelines of the American College of Physicians in 1992 were as follows …
Subclinical hypothyroidism and vascular risk: Αn update
Eirini Lioudaki, Niki G. Mavroeidi, Dimitri P. Mikhailidis, Emmanouel S. Ganotakis
Subclinical hypothyroidism (SCH), defined as elevated serum thyroid-stimulating hormone (TSH) in the presence of normal circulating free thyroxine (FT4) and triiodothyronine (T3), is a relatively common condition. Replacement treatment with levothyroxine is justified only for individuals with TSH levels >10 mIU/l …
The Calcium-Sensing Receptor (CaR) and its Disorders
Edward M. Brown
The system that regulates extracellular calcium (Ca2+o) homeostasis maintains a nearly constant level of Ca2+o so as to ensure the availability of calcium for its numerous intra- and extracellular roles. The molecular cloning and characterization of a G protein-coupled, Ca2+o-sensing receptor has elucidated the mechanism through which parathyroid cells …
Growth and growth hormone secretion in paediatric Cushing’s disease
Martin O. Savage, Helen L. Storr, Ashley B. Grossman, Gerasimos E. Krassas
Although paediatric Cushing’s disease is rare, it is associated with severe morbidity in childhood and presents a major diagnostic and therapeutic challenge for the paediatric endocrinologist. Growth failure remains an important feature of paediatric Cushing’s disease, both at diagnosis and after successful treatment. However, the development of specific diagnostic tests and important therapeutic advances has contributed …