Chittari Venkata Harinarayan
The vitamin D endocrine system in now recognized as subserving a wide range of fundamental biological functions in cell differentiation, inhibition of cell growth as well as immunomodulation. Both forms of immunity, namely adaptive and innate, are regulated by 1,25(OH)2D3. The immune-modulatory properties of vitamin D suggest …
George Vassilakos, Anastassios Philippou, Panagiotis Tsakiroglou, Michael Koutsilieris
Insulin-like growth factor-1 (IGF-1) is a multipotent growth factor involved in the growth, development and regulation of homeostasis in a tissue-specific manner. Alternative splicing, multiple transcription initiation sites and different polyadelynation signals give rise to diverse mRNA isoforms …
Menelaos L. Batrinos
Male pattern baldness, scientifically known as androgenetic alopecia (AGA), is a very common condition, universally prevalent, which progresses with aging. The loss of scalp hair of any degree both in men and women is a cause of considerable psychological distress …
Neoklis A. Georgopoulos, Efstathios Papadakis, Anastasia K. Armeni, Ilias Katsikis, Nikolaos D. Roupas, Dimitrios Panidis
OBJECTIVE: Τo evaluate the impact of elevated serum Δ4A levels on the hormonal and metabolic features of the different phenotypes of PCOS. DESIGN: 1276 women with PCOS according to the Rotterdam criteria were included …
Biljana Nedeljkovic Beleslin, Jasmina Ciric, Milos Zarkovic, Mirjana Stojkovic, Slavica Savic, Miroslav Knezevic, Branislav Stankovic, Bozo Trbojevic
OBJECTIVE: Glucocorticoids (GC) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still . The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period …
Efterpi Chouridou, Maria Lambropoulou, Maria Koureta, Ioanna Balgouranidou, Evangelia Nena, Maria Simopoulou, Nikolaos Papadopoulos, Alexandros Kortsaris, Ekaterini Chatzaki
OBJECTIVE: The Corticotropin Releasing Factor (CRF) system (neuropeptides CRF, Ucn I, II, III and binding sites CRFR1, CRFR2, CRF-BP) is responsible for stress regulation and the homeostasis of an organism. Herein we study the CRF system in human normal and pathological fetal lungs …
Angeliki Angelidi, Andreas Melidonis, Ioannis Protopsaltis, Theodoros N. Sergentanis, Angelos Gritzapis, Ioannis Kornezos, Theofanis Economopoulos, George Dimitriadis, Eleni Boutati, Sotirios A. Raptis
OBJECTIVE: Endothelial progenitor cells (EPCs) have recently been considered as a potential novel marker of vascular integrity, atherosclerosis and cardiovascular risk. This study was performed to investigate the main determinants of EPC levels in individuals with prediabetes …
Carlo Cappelli, Mario Rotondi, Ilenia Pirola, Barbara Agosti, Ana Maria Formenti, Pasquale De Cata, Massimo Salvetti, Luca Chiovato, Maurizio Castellano
OBJECTIVE: Metformin treatment may induce a decrease/suppression in serum TSH levels, mimicking sub-clinical hyperthyroidism (SHT). The aim of the present study was to retrospectively evaluate changes in several electrocardiographic indices in euthyroid subjects with diabetes who, after starting metformin treatment …
Charis Girvalaki, Constantine Vardavas, Christopher Papandreou, Georgia Christaki, Anna Vergetaki, Ioanna G. Tsiligianni, Christos Hatzis, Anthony Kafatos
OBJECTIVE: To investigate all the important factors contributing to the development of metabolic syndrome (MetS) as well as to explore the changes of these factors, over time, by comparing adolescent populations of rural areas of Heraklion, Crete, for the years 2011 and 1989 …
Makarios Eleftheriades, Panagiota Pervanidou, Homeira Vafaei, George Vaggos, Ismene Dontas, Katerina Skenderi, Neil J. Sebire, Kypros Nicolaides
OBJECTIVE: This experimental study aimed to prospectively investigate the impact of combinations of prenatal and postnatal food manipulations on the metabolic profile of adult offspring. DESIGN: On day 12 of gestation, 67 timed pregnant rats were randomized into three nutritional groups …
Carmen Entrala-Bernal, Cristina Montes-Castillo, Maria Jesus Alvarez-Cubero, Carmen Gutiérrez-Alcántara, Francisco Fernandez-Rosado, Esther Martinez-Espίn, Carolina Sánchez-Malo, Piedad Santiago-Fernández
Kallmann Syndrome (KS) is a genetic disease of embryonic development which is characterized by the association of hypogonadotropic hypogonadism (HH) due to a deficit of the gonadotropin-releasing hormone (GnRH) and a hypo/anosmia (including a hypoplasia of the nasal sulcus and agenesis of the olfactory bulbs) …
Zac C. Etheridge, Christopher Schofield, Peter J.J. Prinsloo, Nigel D.C. Sturrock
Hypocalcaemia due to hypoparathyroidism following thyroidectomy is a relatively common occurrence. Standard treatment is with oral calcium and vitamin D replacement therapy; lack of response to oral therapy is rare. Herein we describe a case of hypoparathyroidism following thyroidectomy unresponsive to oral therapy …
Labrini Papanastasiou, Stelios Fountoulakis, Theodora Pappa, Konstantinos Liberopoulos, Dimosthenis Malliopoulos, Athina Markou, George Piaditis
OBJECTIVE: Dopamine agonists (DA) are the treatment of choice in patients with macroprolactinomas. Brain and optic chiasm herniation are unusual complications following treatment with DA. REPORT: We present a case of a giant prolactinoma complicated by visual deterioration following cabergoline treatment …
Marianna Karamanou, Michael Koutsilieris, Konstantinos Laios, Filio Marineli, George Androutsos
Apollinaire Bouchardat is regarded as the founder of the field of Diabetology. His contributions to the field include the first known recommendations for specific diets for the management of Diabetes Mellitus and his emphasis on patient education and self-monitoring. He was moreover a great pharmacist as well as a distinguished physician and biochemist …