Nikolaos E. Koundourakis, Pavlina D. Avgoustinaki, Niki Malliaraki, Andrew N. Margioris
Muscles are major targets of vitamin D. Exposure of skeletal muscles to vitamin D induces the expression of multiple myogenic transcription factors enhancing muscle cell proliferation and differentiation. At the same time vitamin D suppresses the expression of myostatin, a negative regulator of muscle mass …
Chittari Venkata Harinarayan
The vitamin D endocrine system in now recognized as subserving a wide range of fundamental biological functions in cell differentiation, inhibition of cell growth as well as immunomodulation. Both forms of immunity, namely adaptive and innate, are regulated by 1,25(OH)2D3. The immune-modulatory properties of vitamin D suggest …
Marco Di Monaco, Carlotta Castiglioni, Rosa Tappero
OBJECTIVE: Hip-fracture patients with vitamin D deficiency can have either secondary hyperparathyroidism or normal levels of parathyroid hormone (PTH). We hypothesized that bone mineral density (BMD) could be lower in patients with high PTH levels than in those with normal levels of PTH, irrespectively of the severity of vitamin D depletion …
Mauro Doga, Stefania Bonadonna, Andrea Giustina
Chronic exposure to excessive concentrations of endogenous cortisol or to pharmacologic doses of glucocorticoids (GCs) causes multiple deleterious effects on body structure and function. Osteopenia, osteoporosis and bone fractures are well recognized consequences of excessive GC exposure, with fractures being a major cause of morbidity and mortality, particularly in the elderly. In particular, GCs have profound effects on bone metabolism, acting at many sites…
Ze’ev Hochberg, Alan R Templeton
Evolutionary pressures due to variation in climate play an important role in shaping phenotypic variation among and within species and have been shown to influence variation in phenotypes such as body shape and size among humans. Here we review the evidence for migration and change of living latitude in the evolution of skin color genes and the vitamin D receptor (VDR) ..
Wen Xu, Jing Sun, Wenbo Wang, Xiran Wang, Yan Jiang, Wei Huang, Xin Zheng, Qiuping Wang, Zhiwei Ning, Yu Pei, Min Nie, Mei Li, Ou Wang, Xiaoping Xing, Wei Yu, Qiang Lin, Ling Xu, Weibo Xia
OBJECTIVE: To determine if GC (group-specific component globulin) and CYP2R1 genetic variants have an association with serum 25-OHD3 levels, BMD or bone turnover markers in a population of Chinese postmenopausal women …
Korcan Demir, Mehmet Keskin, Yιlmaz Kör, Murat Karaoğlan, Özlem Gümüştekin Bülbül
OBJECTIVE: To assess levels of vitamin D and of immunoglobulin G subclasses in children and adolescents with type 1 Diabetes Mellitus with or without autoimmune thyroiditis. DESIGN: Among 213 patients with type 1 diabetes, the cases with thyroid-specific autoantibodies …
Eva N. Kassi, Spiros Stavropoulos, Panayiotis Kokkoris, Antonis Galanos, Paraskevi Moutsatsou, Cleanthi Dimas, Athanasios Papatheodorou, Christos Zafeiris, George Lyritis
OBJECTIVE: We aimed to determine the prevalence of 25(OH)D (D2 and D3 independently) inadequacy in healthy young/middle-aged men and to investigate its relationship with BMD, bone markers, demographic and lifestyle parameters such as age, BMI, smoking, alcohol consumption and dietary calcium intake …
Dimitra Metheniti, Sophia Sakka, Maria Dracopoulou, Alexandra Margeli, Ioannis Papassotiriou, Christina Kanaka-Gantenbein, George P. Chrousos, Panagiota Pervanidou
OBJECTIVE: Hypovitaminosis D has been associated with adult as well as childhood obesity. Retinol-binding-protein-4 (RBP-4) and Neutrophil Gelatinase-associated Lipocalin (NGAL) are altered in obese individuals. The aim of this study was to examine circulating 25-(OH) Vitamin D (25-(OH) D) concentrations …
Nick Voulgaris, Labrini Papanastasiou, George Piaditis, Anna Angelousi, Gregory Kaltsas, George Mastorakos, Eva Kassi
The role of vitamin D in female reproduction has been intensively examined over the last few decades. A large body of evidence suggests that vitamin D might have beneficial effects on metabolic/hormonal parameters of PCOS and endometriosis, while it appears to be associated with IVF outcomes. However, due to the heterogeneity among observational and interventional studies, no cause-effect relationship has yet been established. The aim of this review is to analyze recent in vitro animal and human studies …
Spyridon N. Karras, William B.Grant, Declan P. Naughton, Kalliopi Kotsa
We read with interest the recent article by Katrinaki et al. The authors report on cross-sectional values of serum 25-hydroxyvitamin D [25(OH)D] concentrations from a large Mediterranean cohort in Crete, Greece …
Maria P. Yavropoulou, Kalliopi Kotsa, Anna Gotzamani Psarrakou, Αlexandra Papazisi, Τheoni Tranga, Stelios Ventis, John G. Yovos
X-linked dominant hypophosphatemic rickets (XLH) is the most prevalent genetic form of hypophosphatemic rickets. Standard treatment of XLH patients includes long-term administration of phosphate and calcitriol. Treated patients usually respond well to the conventional therapy and demonstrate amelioration of rachitic symptoms and improved growth …
Claudia Battista, Raffaella Viti, Salvatore Minisola, Iacopo Chiodini, Vincenzo Frusciante, Alfredo Scillitani, Vincenzo Carnevale
OBJECTIVE: To describe the biochemical effects of an over-supplementation of vitamin D3 in two patients with primary hyperparathyroidism (PHPT). DESIGN: Two patients (A and B) with PHPT took erroneously 2,400,000U …