Vitamin D and aspects of female fertility

Nick Voulgaris, Labrini Papanastasiou, George Piaditis, Anna Angelousi, Gregory Kaltsas, George Mastorakos, Eva Kassi

Download PDF

The role of vitamin D in female reproduction has been intensively examined over the last few decades. A large body of evidence suggests that vitamin D might have beneficial effects on metabolic/hormonal parameters of PCOS and endometriosis, while it appears to be associated with IVF outcomes. However, due to the heterogeneity among observational and interventional studies, no cause-effect relationship has yet been established. The aim of this review is to analyze recent in vitro animal and human studies …

Glucocorticoids and bone: cellular, metabolic and endocrine effects

Mauro Doga, Stefania Bonadonna, Andrea Giustina

Download PDF

Chronic exposure to excessive concentrations of endogenous cortisol or to pharmacologic doses of glucocorticoids (GCs) causes multiple deleterious effects on body structure and function. Osteopenia, osteoporosis and bone fractures are well recognized consequences of excessive GC exposure, with fractures being a major cause of morbidity and mortality, particularly in the elderly. In particular, GCs have profound effects on bone metabolism, acting at many sites…