George A. Garinis
The physicochemical constitution of DNA cannot warrant lifelong stability. Yet, unlike all other macromolecules, nuclear DNA must last the lifetime of a cell ensuring that its vital genetic information is preserved and faithfully transmitted to progeny…
Andrzej Bartke, Michael Bonkowski, Michal Masternak
In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous mutations or targeted disruption of GH- or IGF1-related genes can lead to an impressive increase of longevity…
Zvi Laron
Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man…
Robin P. Peeters
With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly…
Ilpo Huhtaniemi, Juuso I. Mäkinen, Antti Perheentupa, Olli T. Raitakari
Interest has arisen during the last 10 years as to the possible connection between the age-related decline in androgen production and symptoms of ageing in men. A new ageing-related syndrome with several descriptive names …
Yogendra S. Rajawat, Ioannis Bossis
Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins, macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis requires continuous removal of worn-out components and replacement …
Ioannis Karamouzis, Dimitrios Grekas, Michael Karamouzis, Athanasios Triantos, Svetla Vasileva-Staikova, Dimitrios Kovachev, Afroditi Dimitriadou
The concentration of 8-iso-prostaglandin-F2· (8-iso-PGF2α in biological fluids has been considered as the most reliable biochemical index of the lipid peroxidation and oxidative stress in patients with several pathological conditions including end stage renal failure …
Serkan Yener, Abdurrahman Comlekci, Baris Akinci, Pinar Akan, Tevfik Demir, Firat Bayraktar, Sena Yesil
OBJECTIVE: a)To determine serum Transforming Growth Factor-beta 1 (TGF-β1) levels in patients with type 2 diabetes who do not have diabetes related complications and in healthy controls, b) to evaluate the effects of metformin and rosiglitazone on TGF-β1 levels …
Assimina Galli-Tsinopoulou, Eleftheria Emmanouilidou, Paraskevi Karagianni, Maria Grigoriadou, John Kirkos, George S. Varlamis
Silver Russell Syndrome (SRS) is a rare condition (1/3000 – 1/100,000 newborns). We present a female infant with SRS, cardiac malposition and asymmetric enlargement of the clitoris. She is the first child of Greek nonconsanguinous parents, born at 38 weeks gestation …
Menelaos L. Batrinos
Contrary to the commonly held belief that in antiquity and as late as 1700 A.D. normal lifespan was about 35 years, there are indications that the ancient Greeks lived longer. In a study of all men of renown, living in the 5th and 4th century in Greece …