Leonard Wartofsky
Thyroid cancer is the most common endocrine malignancy with more deaths annually than all other endocrine cancers combined. Medical centers in many parts of the world have noted an increasing frequency of cases of thyroid cancer. The general impression has been that if there is a rising frequency, it was likely due to some environmental cause …
Ulla Feldt-Rasmussen, Åse Krogh Rasmussen
Coexistence of differentiated thyroid cancer (DTC) and thyroid autoimmune diseases could represent a mere coincidence due to the frequent occurrence of autoimmunity, but there may also be a pathological and causative link between the two conditions. The coincidence of DTC with Hashimoto’s disease has been variably reported …
Paloma Alonso-Magdalena, Ana Belιn Ropero, Sergi Soriano, Ivan Quesada, Angel Nadal
The aim of this review was to analyze the potential effects of environmental chemicals on homeostatic control related to glycemia and energy balance. Many of the environmental chemicals can mimic or interfere with the action of hormones and are generally referred to as “endocrine disruptors” …
Artemis Karkanaki, Dimitrios Vavilis, Alexandros Traianos, Ioannis Kalogiannidis, Dimitrios Panidis
Women present an estradiol-dependent cardiovascular risk profile. Based on various studies, it was considered that estrogen therapy (ET) in postmenopausal women could probably reduce the higher cardiovascular risk in this group. Assymetric dimethylarginine (ADMA) is an endogenous methylated arginine which inhibits nitric oxide ..
Peter D. Papapetrou
OBJECTIVE: To assess the relationship between circulating 25(OH)D, 1,25(OH)2D, and 24,25(OH)2D in pregnancy at term, and to test the hypothesis that serum 25(OH)D and 24,25(OH)2D are repressed by high serum 1,25(OH)2D levels …
George Dimitriadis, Eleni Boutati, Athanasios E. Raptis, Erifili Hatziagelaki, Panayota Mitrou, Vaia Lambadiari, Nikolaos Tountas, Theofanis Economopoulos, Sotirios A. Raptis
OBJECTIVE: This study was undertaken to assess the accuracy of GlucoDay® – a portable detector of subcutaneous glucose – by comparing the results to those obtained by Biostator® an established and reliable method for continuous glucose measurement in whole blood. DESIGN: Subjects with type 1 diabetes (n:6), subjects with type 2 diabetes …
Panayota Kolypetri, Natasha A. Noel, Karen A. Carayanniotis, George Carayanniotis
OBJECTIVE: In NOD.H2h4 mice, high dietary iodine intake has been known to cause Iodine-accelerated Spontaneous Autoimmune Thyroiditis (ISAT) via an unknown mechanism. The aim of the study was to examine whether the NOD.h4 genetic background predisposes to enhanced iodine organification in thyroglobulin …
Masao Jinno, Kenichi Kondou, Koji Teruya
OBJECTIVE: Insulin resistance is associated with aging and stress, both common among patients repeatedly failing to conceive with in vitro fertilization (IVF repeaters). In the present study we examined whether low-dose metformin could improve the outcome in IVF repeaters without polycystic ovary syndrome (PCOS) …
Eirini Bathrellou, Mary Yannakoulia, Katerina Papanikolaou, Artemios Pehlivanidis, Panagiota Pervanidou, Christina Kanaka-Gantenbein, Ioanna Tokou, John Tsiantis, George P. Chrousos, Labros S. Sidossis
OBJECTIVE: To evaluate the effectiveness of active parental involvement in a lifestyle intervention for the management of childhood obesity. DESIGN: Forty-two overweight children (32 girls and 10 boys), aged 9.2±0.2 years and with percent overweight 39.8±2.7%, were randomly allocated either to a child-and-parent group …
Alma Prieto-Tenreiro, Patricia Diaz-Guardiola
Central Hypothyroidism (Central H) is mainly due to acquired lesions, either in the pituitary, the hypothalamus or both, and in such cases it is usually associated with deficient secretion of other pituitary hormones. Isolated central hypothyroidism (I Central H) remains a very rare disease. By the use of the serum Thyroid Stimulating Hormone …
Shabana Valiji Bharmal, Veronica Moyes, Sahid Ahmed, Ashley Grossman
Drugs are the commonest cause of hypoglycaemia in patients without diabetes mellitus. However, in spite of this, a recent review highlighted the poor quality of evidence available supporting the association between numerous drugs and hypoglycaemia …