Demetrios Moris, Eleftherios Mantonakis, Marinos Makris, Adamantios Michalinos, Spiridon Vernadakis
OBJECTIVE: Hoarseness is a postoperative complication of thyroidectomy, mostly due to damage to the recurrent laryngeal nerve (RLN). Hoarseness may also be brought about via vocal cord dysfunction (VCD) due to injury of the vocal cords from manipulations during anesthesia, as well as from psychogenic disorders …
Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Andreina Manfredi, Caterina Mancusi, Silvia Fabiani, Marco Centanni, Santino Marchi, Clodoveo Ferri, Alessandro Antonelli
OBJECTIVE: The prevalence and clinical features of thyroid involvement in patients with hepatitis C virus-associated mixed cryoglobulinemia (MC+HCV) have been reviewed. DESIGN: A PubMed Medline search was conducted through December 2011 to identify all studies that reported thyroid involvement …
Maria P. Yavropoulou, John G. Yovos
During the last decade a considerable amount of data have been accumulated regarding the role of intracellular signaling pathways in the pathogenesis of human diseases. One of these, Notch signaling, well known for its significance in cellular development and tissue morphogenesis, has been increasingly recognized as a crucial participant …
Anastasia D. Dede, George P. Lyritis, Symeon Tournis
Anorexia nervosa is a serious psychiatric disorder accompanied by high morbidity and mortality. It is characterized by emaciation due to self-starvation and displays a unique hormonal profile. Alterations in gonadal axis, growth hormone resistance with low insulin-like growth factor I levels, hypercortisolemia and low triiodothyronine …
Franziska M. Hanusch, Evelyn Fischer, Katharina Lang, Sven Diederich, Stephan Endres, Bruno Allolio, Felix Beuschlein, Martin Reincke, Marcus Quinkler, for the participants of the German Conn’s Registry
OBJECTIVE: In subjects at high risk for sleep apnea (SA), aldosterone concentrations correlate with severity of SA and primary aldosteronism (PA) is very often diagnosed. Patients with PA show a high prevalence of SA. Treatment of PA either by adrenalectomy (ADX) or mineralocorticoid receptor (MR) blockade is thought to abolish …
Evangelia Tantalaki, Christina Piperi, Sarantis Livadas, Anastasios Kollias, Christos Adamopoulos, Aikaterini Koulouri, Charikleia Christakou, Evanthia Diamanti-Kandarakis
OBJECTIVE: To investigate the impact of dietary intervention on Advanced Glycation End products (AGEs) intake on the hormonal and metabolic profile in women with polycystic ovary syndrome (PCOS). METHODS: After baseline evaluation, 23 women with PCOS …
Antonio J. Amor, Irene Halperin, Rocίo Alfayate, Victoria M. Borrás, Arancha Escribano, Cintia González, Antonio Gutirrez, Montserrat Mauri, Pilar Pérez, Antonio Picό, Irene Vourliotaki, Josep Oriola
OBJECTIVE: The aim of the study was to describe the clinical, biochemical, and genetic features of a sample of Mediterranean patients with RTH (resistance to thyroid hormone) due to mutations in TRβ (thyroid hormone receptor beta) referred to our institution during the last 15 years …
Christos Maniotis, Klio Chantziara, Panagiotis Kokkoris, Dimitrios Papadogiannis, Constantinos Andreou, Constantinos Tsioufis, Georgios Vaiopoulos, Christodoulos Stefanadis
OBJECTIVE: This study surveyed the frequencies of single nucleotide polymorphisms (SNPs) M235T AGT and C825T GNB3, and their association with insulin resistance, other biochemical markers and qualitative variables in subjects with high normal blood pressure and/or prehypertension in the Greek population …
Georgios Valsamakis, Dimitrios C. Papatheodorou, Alexandra Margeli, Vassilios Bakoulas, Efthymios Kapantais, Ioannis Papassotiriou, George Creatsas, Sudhesh Kumar, George Mastorakos
OBJECTIVE: The role of first trimester maternal body mass index (BMI) and adipocytokines in cord blood c-peptide and birth weight in pregnancy was investigated. DESIGN: Seventy non-diabetic pregnant Caucasian women were recruited …
Elisa Sala, Emanuele Ferrante, Marco Locatelli, Paolo Rampini, Giovanna Mantovani, Claudia Giavoli, Marcello Filopanti, Elisa Verrua, Elena Malchiodi, Giorgio Carrabba, Maura Arosio, Paolo Beck-Peccoz, Anna Spada, Andrea Gerardo Lania
OBJECTIVE: Transsphenoidal (TNS) surgery remains the primary therapeutic option for GH-secreting pituitary adenomas. The aims of this study were to verify the impact of TNS surgery on treatment of acromegaly before and after identification by a dedicated neurosurgical team and to enumerate diagnostic features …
Nikolaos E. Koundourakis, Nikolaos Androulakis, Eirini C. Spyridaki, Elias Castanas, Niki Malliaraki, Christos Tsatsanis, Andrew N. Margioris
OBJECTIVE: To examine the effects of three seasonal training programs, largely different in strength volume, on androgen levels and performance parameters in soccer players. DESIGN: Sixty-seven soccer players, members of three different professional teams, participated in the study …
Anastasia Sfikakis, Pothitos M. Pitychoutis, Aikaterini Tsouma, Ioanna Messari, Zeta Papadopoulou-Daifoti
OBJECTIVE: To examine the impact of circulating testosterone (T) and the T/Estradiol (T/Ediol) ratio on chronic stress-induced changes of adrenal and hippocampal weight during proestrus (PE) and estrus (E) in female rats. DESIGN: Stress was composed of repeated vaginal smear screening (VSS) and measured by the emotional reactivity score …
Filippo Ceccato, Gianluca Occhi, Daniela Regazzo, Maria Luigia Randi, Diego Cecchin, Marina Paola Gardiman, Renzo Manara, Giuseppe Lombardi, Luca Denaro, Franco Mantero, Carla Scaroni
BACKGROUND: Most pituitary adenomas with FSH- or LH-positive immunohistochemistry are endocrinologically silent, and neurological symptoms due to their large volume are the first clinical signs; they are rarely reported to be secreting gonadotropins, this usually occurring in cases with clinical endocrine findings …
Eftekhar H. Al Ojaimi
Although Cushing’s syndrome has been described in association with various neuroendocrine tumors producing ectopic adrenocorticotropin (ACTH), primary ovarian carcinoma rarely causes this syndrome. We hereby report the case of a 61-year-old woman presented with abdominal distension, facial swelling and skin pigmentation …
Olga Karapanou, Barbara Vlassopoulou, Marinella Tzanela, Dimitrios Papadopoulos, Panagiotis Angelidakis, Helen Michelakakis, George Ioannidis, Markos Mihalatos, Smaragda Kamakari, Stylianos Tsagarakis
We present the clinical and hormonal findings of a young male with X-linked adrenoleukodystrophy (X-ALD), with special emphasis on the biochemical and clinical pattern of hypogonadism. A patient, with primary adrenal insufficiency since the age of 5 years, developed progressive neurological symptoms at the age of 29 …
Anastasia K. Armeni, Vasiliki Vasileiou, Neoklis A. Georgopoulos
Cases of sexual reassignment in classical antiquity, namely a female-to-male gender change occurring after childhood, are described in the literature. Textual evidence concerning these cases of androgynism and their symbolism as well as a comprehensive scholar analysis is provided in the present study …