Gonzalo Díaz-Soto, María Teresa Julián, Manel Puig-Domingo
Normocalcemic primary hyperparathyroidism (NCHPT) is a new entity which possibly represents a “fruste form” of classic clinically symptomatic hyperparathyroidism. Over the last decade it has generated considerable scientific interest …
George P. Chrousos, Achille Gravanis, Andrew (Andy) N. Margioris
Wylie Walker Vale, Jr. was born in Houston, Texas, on July 3, 1941. While still in high school, he met and fell in love with his wife Betty to whom he was married for over 40 years. Wylie earned his bachelor’s degree in Biology …
Giorgio Treglia, Guido Rindi, Vittoria Rufini
Thyroid carcinoma is the most frequent type of endocrine tumour. Most differentiated thyroid cancers (DTCs) have an excellent prognosis if diagnosed early and treated appropriately. Nevertheless, a number of patients with DTCs do not achieve remission after thyroidectomy …
Athanasios N. Tsartsalis, Charalambos Dokos, Georgia D. Kaiafa, Dimitris N. Tsartsalis, Antonios Kattamis, Apostolos I. Hatzitolios, Christos G. Savopoulos
Osteoporosis is a major health problem affecting both men and women. Statins, besides their action as lipid-lowering agents, seem to have additional pleiotropic properties, among them a beneficial effect on bone mineral density. The entirety of experimental and the majority of clinical studies …
Zoe Iliodromiti, Nikolaos Antonakopoulos, Stavros Sifakis, Panagiotis Tsikouras, Angelos Daniilidis, Kostantinos Dafopoulos, Dimitrios Botsis, Nikolaos Vrachnis
Considering that preterm birth accounts for about 6-10% of all births in Western countries and of more than 65% of all perinatal deaths, elucidation of the particularly complicated mechanisms of labor is essential for determination of appropriate and effective therapeutic interventions …
Adeeb Shehzad, Waqas Iqbal, Omer Shehzad, Young Sup Lee
Adiponectin is a white and brown adipose tissue hormone, also known as gelatin-binding protein-28 (GBP28), AdipoQ, adipocyte complement-related protein (ACRP30), or apM1. Adiponectin circulates in the bloodstream in trimeric, hexameric, and high-molecular-mass species, while different forms of adiponectin …
Antonis Polymeris
Obesity both in adults and children has emerged as a worldwide epidemic. Obesity is associated with an increased risk of a number of comorbidities including type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea …
Menelaos L. Batrinos
Clusters of poorly demarcated neurons, called nuclei, situated in the hypothalamic area are the source of hormones which through the succession of their actions on the pituitary and the peripheral endocrine glands, regulate and control major functions …
Lampros Fotis, Dionysios Giannakopoulos, Lela Stamogiannou, Maria Xatzipsalti
In 1995 David Barker formulated the ‘Barker hypothesis’ according to which there is a correlation between undernutrition in utero and several diseases in adult life. More specifically, undernutrition in utero permanently affects the vascular bed, resulting in a predisposition to diseases later on …
Hesham Fahmy, Katerina Spyridaki, Bhimanna Kuppast, George Liapakis
The maintenance of homeostasis is a basic prerequisite for life, ensuring the stability of our body in response to external or internal stimuli (stressful stimuli). The maintenance of homeostasis requires alterations in the function of the endocrine system …
Nikolaos Pontikides, Spyros Karras, Athina Kaprara, Angeliki Cheva, Argyrios Doumas, Dimitrios Botsios, Aris Moschidis, Elias Efthimiou, John Wass, Gerasimos E. Krassas
BACKGROUND: Parathyroid cysts (PC) are uncommon entities in routine clinical practice. The vast majority are nonfunctioning and are commonly present as asymptomatic nodular cervical lesions. PC should be considered in the differential diagnosis of an asymptomatic neck mass …
Predrag Miljic, Dragana Miljic, Joshua William Cain, Márta Korbonits, Vera Popovic
Chronic exposure to high glucocorticoid levels in Cushing’s syndrome (CS) is often associated with alterations in the hemostatic system and the expression of prothrombotic phenotypes. Increased frequency of both atherothrombotic and venous thromboembolic events (VTE) has been reported in patients with CS …
Stergios A. Polyzos, Athanasios D. Anastasilakis, Georgios Arsos
Fine needle biopsy (FNB) is regarded as the method of choice in the management of thyroid nodules because of its simplicity, reliability, accuracy and cost-effectiveness. Indeed, the use of FNB has halved the number of patients undergoing thyroidectomy …
Marià Alemany
The clairvoyant early implication of sex hormones in the characterization of the metabolic syndrome (MS) was detected early, and in accordance with the well-known sex-related main patterns of fat deposition in obesity: gynoid and android …
Ioannis D. Kostakis, Kyriaki G. Cholidou, Despina Perrea
The distal nephron, which is the site of the micro-regulation of water absorption and ion handling in the kidneys, is under the control of aldosterone. Impairment of the mineralocorticoid signal transduction pathway results in resistance to the action of aldosterone and of mineralocorticoids in general …
Victoria Salem, Thomas G. Hopkins, Heba El-Gayar, Sagen Zac-Varghese, Anthony P. Goldstone, Jeannie F. Todd, Waljit Dhillo, Benjamin C.T. Field, Niamh Martin, Emma Hatfield, Mandy Donaldson, Fausto Palazzo, Karim Meeran, James Jackson, Tricia Tan
CONTEXT: Adrenal vein sampling (AVS) is recommended in all patients with hyperaldosteronism to whom surgery would be offered if the results indicated unilateral hypersecretion. OBJECTIVE: To assess the performance of AVS against radiological findings …
Kalliopi Pazaitou-Panayiotou, Eva Tiensuu Janson, Triantafyllia Koletsa, Vassiliki Kotoula, Mats Stridsberg, Georgios Karkavelas, Georgia Karayannopoulou
OBJECTIVE: Peptide receptor radionuclide therapy (PRRT) is dependent upon binding of radiolabelled peptides to their respective receptor expressing cells. The main objective of this study was to characterize the expression of somatostatin receptor (SSTR) subtypes in non-medullary thyroid …
Athanasios D. Anastasilakis, Stergios A. Polyzos, Polyzois Makras, Lampros Kampas, Rosalia-Maria Valeri, Kyriakoulis Dimitrios, Thomas Zarampoukas, Maria Alevizaki
Papillary thyroid microcarcinomas (PTMCs) have an excellent prognosis, although a few may metastasize to cervical lymph nodes. However, an infiltrated palpable neck node without evidence of thyroid disease at presentation is uncommon. We report a patient with PTMC presenting …
Anthony C. Hackney, Ashley Kallman, Karen P. Hosick, Daniela A. Rubin, Claudio L. Battaglini
OBJECTIVE: To compare the thyroid hormonal responses to high-intensity interval exercise (IE) and steady-state endurance exercise (SEE) in highly trained males (n=15). DESIGN: The IE session consisted of repeated periods of 90-seconds treadmill running at 100-110% …
Krystallenia I. Alexandraki, Mohammed Munayem Khan, Harvinder S. Chahal, Nadezhda S. Dalantaeva, Giampaolo Trivellin, Dan M. Berney, Philippe Caron, Vera Popovic, Marija Pfeifer, Suzanne Jordan, Márta Korbonits, Ashley B. Grossman
OBJECTIVE: The model of “oncogene-induced senescence” (OIS), resulting in cell-proliferation arrest, has recently been suggested as a possible explanation for the non-progression of pituitary tumours to malignancy. The aim of the study was to compare the expression …
Emanuele Ferrante, Valentina Morelli, Claudia Giavoli, Giovanna Mantovani, Elisa Verrua, Elisa Sala, Elena Malcmiodi, Silvia Bergamaschi, Eriselda Profka, Elisa Cairoli, Serena Palmieri, Iacopo Chiodini, Andrea-Gerardo Lania, Anna Spada, Paolo Beck-Peccoz
OBJECTIVE: The diagnosis of hypothalamic-pituitary-adrenal insufficiency (HPAI) is a major clinical challenge. The gold standard procedure remains insulin tolerance test (ITT). This study aimed to evaluate the usefulness of standard-dose corticotrophin stimulation test (SDCT) in diagnosing HPAI …
Spiridon Dimas, Spiridon Michas, Ioannis Christakis, Christos Augoustis, Maria Alevizaki
OBJECTIVE: Previous neck surgery (PNS) in patients with primary hyperparathyroidism (PHP) is considered as a contraindication for minimally invasive parathyroidectomy (MIP). The purpose of our study was to determine the effectiveness of MIP in such patients …
Themistoklis N. Spyridopoulos, Nick Dessypris, Antonis G. Antoniadis, Spyros Gialamas, Constantine N. Antonopoulos, Konstantina Katsifoti, Hans-Olov Adami, George P. Chrousos, Eleni Th. Petridou, and the Obesity and Cancer Oncology Group
OBJECTIVE: Obesity and diabetes are considered risk factors for Renal Cell Carcinoma (RCC). We aimed to explore whether insulin resistance (IR) plays an independent role in the development of RCC. DESIGN: In a hospital-based case-control study, we analyzed serum glucose …
Foteini Malli, Alexandra Bargiota, Kathrin Theodoridou, Zoi Florou, Fotini Bardaka, George N. Koukoulis, Konstantinos I. Gourgoulianis, Zoe Daniil
OBJECTIVE AND DESIGN: Sarcoidosis has been associated with thyroid diseases. However, until today no definite conclusions have been drawn. We aimed to assess the frequency of thyroid disorders and the levels of thyroid hormones and thyroid antibodies in 68 sarcoidosis patients and 75 controls …
Neoklis A. Georgopoulos, Anastasia Theodoropoulou, Nikolaos D. Roupas, Loredana Rottstein, Athanasios Tsekouras, Panagiotis Mylonas, George A. Vagenakis, Eftychia Koukkou, Anastasia K. Armeni, George Sakellaropoulos, Michel Leglise, Apostolos G. Vagenakis, Kostas B. Markou
PURPOSE: The aim of this study was to determine the impact of intensive training on adult final height in elite female rhythmic and artistic gymnasts. METHODS: The study included 215 rhythmic gymnasts (RG) and 113 artistic gymnasts (AG) …