Stress neuropeptides in the human endometrium: Paracrine effects on cell differentiation and apoptosis

Achille Gravanis, Antonis Makrigiannakis, Ekaterini Chatzaki, Emmanuel Zoumakis, Christos Tsatsanis, Andrew N. Margioris

Human endometrium exhibits characteristics of a neuroendocrine-like stress organ in addition to its classical role as the main target of ovarian steroid hormones. Indeed, the epithelial cells of human endometrium express the stress-associated neuropeptide genes corticotropin-releasing hormone (CRH), proopiomelanocortin, proenkephalin and prodynorphin…

Treatment of advanced neuroendocrine tumours with the radiolabelled somatostatin analogue octreotide

Gregory A. Kaltsas, Zoe Stefanidou, Dimitris Papadogias, Ashley B. Grossman

Neuroendocrine tumours (NET) have a particular tendency to express functional receptors and/or uptake mechanisms. Radionuclides, such as 111In-pentetreotide, a somatostatin analogue, which bind to somatostatin receptors, present an imaging modality that has been used for both the diagnosis and staging of NET…

Endemic Goiter – an update

Demetrios A. Koutras

“Goiter” means thyroid enlargement, and “endemic” means frequent in a certain locality. The problem is from what volume and up a thyroid is considered to be large enough as to be classified as goiter and also from what prevalence and up an area is considered to be endemic. It is obvious that by playing with these definitions one may increase or decrease …

Compensatory adrenal growth in relation to stress of surgery and estradiol in adult male rats

Nicholas Bikas, Joan Gribisi, Joan Messari and Anastasia Sfikakis

ACTH infusion at the time of unilateral adrenalectomy inhibits the early rapid compensatory growth (CAG) in the remaining adrenal. We examined the hypothesis that different duration of surgery and/or the enhanced response to the stress of surgery, induced by estradiol treatment, might modify CAG. Adult male rats untreated …