Derek V. Henley, Kenneth S. Korach
A large number of natural and synthetic chemicals have been identified that are reported to disrupt the normal functioning of the endocrine system and produce untoward effects in hormone-responsive target tissues and organs in both humans and animals. These chemicals are broadly referred to as endocrine disrupting chemicals (EDCs) and consist of numerous physically …
Retha R. Newbold
Environmental chemicals with hormone-like activity can disrupt programming of endocrine signaling pathways during development and result in adverse effects, some of which may not be apparent until much later in life. Recent reports link exposure to environmental endocrine disrupting chemicals during development with adverse health consequences …
Eleni Kousta, Asteroula Papathanasiou, Nicos Skordis
There have been considerable advances concerning understanding of the early and later stages of ovarian development; a number of genes have been implicated and their mutations have been associated with developmental abnormalities …
Nicholas J. Sarlis, Christian A. Koch
We read with interest the contribution by Dr. Kostopanagiotou and colleagues describing the differential impact of volatile and intravenous anaesthetics on select hormonal and immune parameters of the stress response in the swine. We would like to highlight earlier human data of ours (some of which unpublished to date) as well as from others that are pertinent to this interesting line of research and generally supportive of the authors’ conclusions …
Vladimir Jovanovic, Sandra Pekic, Marko Stojanovic, Goran Tasic, Branko Djurovic, Ivan Soldatovic, Mirjana Doknic, Dragana Miljic, Marina Djurovic, Milica Medic-Stojanoska, Vera Popovic
OBJECTIVE: Subarachnoid hemorrhage (SAH) is a recently identified risk factor for hypopituitarism, particularly growth hormone (GH) and corticotrophins deficiencies. The aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in SAH survivors. DESIGN: Pituitary function was evaluated in 93 patients …
Valentine V. Fadeyev, Tatyana B. Morgunova, Galina A. Melnichenko, Ivan I. Dedov
Objective: The objective of this study was to compare various parameters in patients with hypothyroidism receiving either monotherapy with L-Thyroxine (L-T4) or combination therapy with L-T4 and L-Triiodothyronine (L-T3). Design: We conducted a randomized, controlled trial in 36 premenopausal women with hypothyroidism …
George N. Koukoulis, Christina Sakka, Fotis Katsaros, Maria Goutou, Sofia Tsirona, Efthimia Tsiapali, Aristea Piterou, Ioannis Stefanidis, Nikolaos Stathakis
OBJECTIVE: To investigate the prevalence of obesity in adults of a large region of Central Greece. DESIGN: The target group was adults aged 18 to 79 years who were residents of the region of Thessaly for at least one year. A sample of 852 individuals stratified for sex and age were included. Each subject underwent a thorough physical examination and body mass index …
Sibel Ertek, Arrigo FG Cicero, Oya Caglar, Gurbuz Erdogan
OBJECTIVE: Zinc is essential for many biochemical processes and also for cell proliferation. Thyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. Additionally, zinc deficiency affects thyroid function. The aim of the present study was to evaluate a possible association of zinc levels with thyroid volume …
Nikiforos Ballian, Ioannis I. Androulakis, Klio Chatzistefanou, Christianna Samara, Konstantinos Tsiveriotis, Gregory A. Kaltsas
Radiation-induced optic neuropathy is a rare adverse effect of radiotherapy applied for the treatment of pituitary adenomas. We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy …
Maria P. Yavropoulou, Kalliopi Kotsa, Anna Gotzamani Psarrakou, Αlexandra Papazisi, Τheoni Tranga, Stelios Ventis, John G. Yovos
X-linked dominant hypophosphatemic rickets (XLH) is the most prevalent genetic form of hypophosphatemic rickets. Standard treatment of XLH patients includes long-term administration of phosphate and calcitriol. Treated patients usually respond well to the conventional therapy and demonstrate amelioration of rachitic symptoms and improved growth …