Vera Popovic, Felipe F. Casanueva
Recent data suggest that in addition to leptin’s role in conveying signals of the amount of energy stores to the central nervous system, this adipocyte secreted hormone interacts with the endocrine system to provide critical information about the size of fat stores, acting as a permissive factor that allows the triggering of energy demanding situations …
Evagelos N Liberopoulos, Moses S Elisaf
Thyroid disorders are known to influence lipid metabolism and are common in dyslipidemic patients. Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. Although thyroid substitution therapy is beneficial for patients with overt hypothyroidism …
Maria Alevizaki, Ilpo Huhtaniemi
The pituitary glycoprotein hormones thyrotrophin (thyroid-stimulating hormone, TSH), lutrophin (luteinising hormone, LH) and follitrophin (follicle-stimulating hormone, FSH), as well as the placental choriongonadotrophin (human chorionic gonadotrophin, hCG) are composed of a common α-subunit and a specific β-subunit, coupled by noncovalent interactions …
Dimitra Vasiliadi, Yannis Gratsias, Stylianos Tsagarakis, Eythimia Botoula, Panagiotis Trivizas, Nick Thalassinos, Paraskevi Moutsatsou
Glucocorticoids (GC) affect virtually all organ systems, acting mainly via the glucocorticoid receptor (GR). The immune system is the best characterized tissue for assessing GC sensitivity. It is well established that the immune system GC sensitivity varies widely between normal subjects …
Odysseas Gregoriou,George Christodoulakos, Charalambos Siristatidis, Socrates Conidaris, Evangelia Kouskouni, George Creatsas
Objective: The purpose of this study was to examine the effects of Hormone Replacement Therapy (HRT) on plasma lipoprotein levels, bone mass and the endometrium. Methods: Thirty healthy women were enrolled in the study for climacteric symptoms and received a combination of 17β-estradiol and norethisterone acetate continuously for 2 years …
Anastasios Papadimitriou, Dimitrios Chiotis, Georgios Tsiftis, Maria Hatzisimeon, Maria Maniati, Xenofon Krikos, Anastasia Tzonou, Catherine Dacou-Voutetakis
Statural growth is dependent on hereditary and environmental factors, i.e disease, nutrition. The improvement of socioeconomic conditions that took place during the 20th century resulted in a secular trend towards greater height and earlier sexual maturation. Greek society has changed dramatically from a mainly agricultural society …
Athina Markou, Justin Vale, Bhumita Vadgama, Marjori Walker, Stephen Franks
A 29-year old male and his wife presented with an 18 month history of primary infertility. History and initial investigations suggested no major female pathologic component but a semen analysis revealed azoospermia. There was no history of any sexual dysfunction and neither partner was receiving any medication …
Fotini Malandrinou, Sofia Tseleni-Balafouta, Nicolaos Kakaviatos, Panagiotis Singhellakis
A 42-year old white female with a primary Malignant Fibrous Histiocytoma (MFH) is described. The patient was examined for a “cold” nodule of the thyroid diagnosed five years previously. The patient had been on L-thyroxine therapy for three years which was discontinued by the patient 18 months prior to the present visit …
Christos S. Bartsocas
Among the several causes of short stature is pycnodysostosis, also known as “Toulouse-Lautrec’s disease”. Robert Weismann-Netter is credited with the first description of the disorder which later became known as pycnodysostosis. Only a few, however, know that pycnodysostosis was also possibly Aesop’s disease …