Update in thyroid imaging. The expanding world of thyroid imaging and its translation to clinical practice

Gonzalo Díaz Soto, Irene Halperin, Mattia Squarcia, Francisco Lomeña, Manuel Puig Domingo

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In recent years thyroid imaging has marked exponential progress, considerably changing the approach to diagnosis, prognosis, treatment, follow-up and evaluation of high prevalence thyroid diseases such as goitre, thyroid nodules and primary thyroid cancer. What is more, this notable technical advance has proven its ability to effectively confront such complex challenges …

Obesity in pregnancy

Natalia Sirimi, Dimitrios G. Goulis

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Obesity, the most common metabolic disorder, concerns, among others, women of reproductive age and, when it occurs before or during pregnancy, constitutes a major risk factor for both maternal and fetal complications. The complications of obesity in a prospective mother include subfertility, miscarriage, thrombo-embolism, hypertensive disorders …

Evolutionary perspective in skin color, vitamin D and its receptor

Ze’ev Hochberg, Alan R Templeton

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Evolutionary pressures due to variation in climate play an important role in shaping phenotypic variation among and within species and have been shown to influence variation in phenotypes such as body shape and size among humans. Here we review the evidence for migration and change of living latitude in the evolution of skin color genes and the vitamin D receptor (VDR) ..

Coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. A retrospective study

Elias E. Mazokopakis, Anastasios A. Tzortzinis, Elpida I. Dalieraki-Ott, Athanasios N. Tsartsalis, Periklis K. Syros, Christos M. Karefilakis, Maria G. Papadomanolaki, Ioannis K. Starakis

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OBJECTIVE: The association between Hashimoto’s thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains controversial in medical bibliography. The main objective of our study was to determine the prevalence of PTC and HT coexistence in histopathologic material of thyroidectomized patients. DESIGN: In a retrospective study …

Complications and risk factors related to the extent of surgery in thyroidectomy. Results from 2,043 procedures

Stavros N. Karamanakos, Kostas B. Markou, Konstantinos Panagopoulos, Dionisios Karavias, Constantinos E. Vagianos, Chrisoula D. Scopa, Vassiliki Fotopoulou, Anna Liava, Konstantinos Vagenas

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OBJECTIVE: To evaluate the rate of complications and the risk factors in relation to the extent of surgery in patients undergoing thyroidectomy in a tertiary university center. DESIGN: Data were collected retrospectively from 2,043 consecutive patients who underwent thyroid surgery for various thyroid diseases at the University Hospital of Patras …

The effect of Dehydroepiandrosterone on insulin resistance in patients with impaired glucose tolerance

Afsaneh Talaei, Masoud Amini, Mansour Siavash, Maryam Zare

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OBJECTIVE: Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S) are the most abundant steroid hormones in the body. Recently, DHEA-S has gained interest as an antidepressant substance, with positive effects on autoimmune disease such as lupus and ulcerative colitis, as well as obesity, cancer, cardiovascular disease and diabetes …

Spontaneous recovery from isolated post-traumatic central hypogonadism in a woman

Rosaria M. Ruggeri, Giovanni Smedile, Francesca Granata, Marcello Longo, Salvatore Cannaíò, Nicholas J. Sarlis, Francesco Trimarchi, Salvatore Benvenga

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OBJECTIVE. Hypopituitarism is a recognized complication of Traumatic Brain Injury (TBI). Resolution of established anterior pituitary hormones deficiency is rare. CASE REPORT. A woman was initially presented at the age of 22 years with amenorrhoea. Two years earlier she had been involved in a car accident with consequent TBI …

Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid

Salvatore Maria Corsello, Rosa Maria Paragliola, Pietro Locantore, Francesca Ingraudo, Maria Pia Ricciato, Carlo Antonio Rota, Paola Senes, Alfredo Pontecorvi

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Zoledronic acid is a newly FDA-approved bisphosphonate for the treatment of hypercalcemia of malignancy. Although the safety and efficacy of this drug in treating hypercalcemia associated with hyperparathyroidism have not yet been established in clinically controlled trials, its off-label use is not uncommon …

Goiter depicted in Byzantine artworks

László G. Józsa

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Pathologies depicted in sacral works of western civilisation are widely known. However, in this regard, the very rich and important Byzantine art, and particularly sacral art, has been largely ignored. Research carried out on 500 artworks has disclosed 119 pictures revealing 36 different physiological conditions (gravidity, labour) or pathological conditions …