Category: Volume 4 (2005)

Growth hormone binding protein and acid labile subunit levels in the assessment of acromegaly treatment

Posted on by

Marinella Tzanela, Marieta Christoforaki, Lida Papastathopoulou, Dimitra Vassiliadi, Effie Botoula, Panagiotis Trivizas, Nikos C. Thalassinos

Download PDF

Objective: Post-treatment monitoring of acromegalic patients is a matter of controversy, as discrepancies between GH and IGF-I levels have been reported. The aim of our study was to evaluate the role of acid-labile subunit (ALS), a component of the 150 kD IGF-I/IGFBP-3/ALS complex, and the growth hormone binding protein (GHBP) in the follow-up of patients with acromegaly after therapeutic intervention…

The use of Data Mining in the categorization of patients with Azoospermia

Posted on by

Themistoklis Mikos, Konstantinos Pantazis, Dimitrios G. Goulis, Nikolaos Maglaveras, John N. Bontis, John Papadimas

Download PDF

OBJECTIVE: Data Mining is a relatively new field of Medical Informatics. The aim of this study was to compare Data Mining diagnosis with clinical diagnosis by applying a Data Miner (DM) to a clinical dataset of infertile men with azoospermia. DESIGN: One hundred and forty-seven azoospermic men were clinically classified into four groups …

Effects of GH and IGF-I on the in vitro maturation of mouse oocytes

Posted on by

Erasmia Kiapekou, Dimitris Loutradis, Peter Drakakis, Evangelia Zapanti, George Mastorakos, Aristidis Antsaklis

Download PDF

Objective: A number of hormones and growth factors have been reported to affect the in vitro maturation of oocytes. Their exact effects on follicular growth and oocyte maturation and the mechanisms involved are still unclear. In the present study, we have investigated the effects of Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) …

A unique case of a benign adrenocortical tumor with triple secretion of cortisol, androgens, and aldosterone. Development of multiple sclerosis after surgical removal of the tumor

Posted on by

Athina Markou, Kaity Tsigou, Dimitrios Papadogias, Kostas Kossyvakis, Kyriakos Vamvakidis, Theodora Kounadi, George Piaditis

Download PDF

We present a 39-year old female with a benign adrenal tumor characterized by autonomous secretion of cortisol, androgens, and aldosterone. The patient presented with a 4-year history of hypertension and severe hirsutism. Baseline investigations revealed elevated testosterone, androstendione, and 17OH progesterone with normal levels of dehydroepiandrosterone sulfate…

Hypoparathyroidism in a patient presenting with severe myopathy and skin rash. Case report and review of the literature

Posted on by

Vassiliki Syriou, Asimina Kolitsa, Lamprini Pantazi, Dimitrios Pikazis

Download PDF

A 47-year old man with idiopathic hypoparathyroidism (IHP), presented as severe myopathy and skin rash is described. The serum muscle enzymes were increased. After treatment with calcium and vitamin D, the clinical condition improved, the skin rash gradually disappeared, and the muscle enzymes decreased and remained within the normal range thereafter.

Ectopic thyroid tissue in the lower neck with a coexisting normally located multinodular goiter. Brief literature review

Posted on by

Eleni Kousta, Konstantinos Konstantinidis, Christina Michalakis, George E. Theodoropoulos, Michalis Vorias, Michalis Georgiou, George Sambalis

Ectopic thyroid tissue in the lower neck with a coexisting normally located multinodular goiter is a rare entity. We present a 27-year old asymptomatic woman with a recent history of a painless mass in the left side of her lower neck. Thyroid function tests were normal. An ultrasound of her neck showed a multinodular goiter and a 3.4 cm solid mass in the left lower cervical area…

A case of a prolactinoma resistant to dopamine agonists

Posted on by

Irene Vourliotaki, Ingrid Elizabeth Bonapart, Catherine Stamataki, Eva-Maria Tsapakis, Catherine Saridaki

Download PDF

Dopamine agonists are the drugs of choice in the treatment of prolactinomas, the most common type of pituitary adenomas. However, up to 25% of prolactinomas do not respond to these drugs and alternative treatments have to be considered. We describe a 37-year old female with a microprolactinoma who, although having received all available formulations of dopamine agonists …

Hypophosphataemic osteomalacia due to de Toni-Debre-Fanconi syndrome in a 19-year old girl

Posted on by

Tasoula Tsilchorozidou, John G Yovos

Download PDF

Osteomalacia associated with adult onset Fanconi syndrome is thought to result from hypophosphataemia due to renal phosphate loss and relative 1,25-dihydroxyvitamin D3 deficiency. In this disorder, the impaired renal phosphate uptake occurs as part of a generalized tubular defect in association with other features such as bicarbonuria, glycosuria and aminoaciduria…

On the centenary of the term

Posted on by

Effie Poulakou-Rebelakou, Costas Tsiamis, Spyros G. Marketos

Download PDF

In June of 2005 the term hormone completed a life span of one century. The word that Ernest Henry Starling included in one of his four lectures to the Royal Society of Physicians of London, given in June 1905, definitively established the permanent representation in terminology for the products secreted by the endocrine glands…

Obesity and renal disease: A possible role of leptin

Posted on by

Dafni-Kalliopi Papafragkaki, George Tolis

Download PDF

Obesity is one of the most frequently encountered medical problems of our time. Among the complications of this pathologic entity, renal disease is an important issue and its pathophysiologic mechanisms are a challenge for the physician, since a variety of etiologic factors are implicated in its genesis. For example, hypertension, hyperlipidemia and insulin resistance …