Catherine Dacou-Voutetakis
The case presented by Petzold et al in this issue1 highlights certain critical aspects of management of the child and adolescent with endocrine problems which are both of theoretical and practical interest. First, the discrepancy between the hormonal profile and the clinical manifestations …
Evangelia Zapanti, Konstantinos Terzidis, George Chrousos
Abnormalities of the Hypothalamic-Pituitary-Adrenal (HPA) axis have been documented in HIV patients in the early as well as late stages of the infection and range from subtle subclinical disturbances to frank adrenal insufficiency. Potential etiologies of these disorders include opportunistic infections, neoplasms …
Angeliki Galani, Sophia Kitsiou-Tzeli, Christalena Sofokleous, Emmanuel Kanavakis, Ariadni Kalpini-Mavrou
The end-organ resistance to androgens has been designated as Androgen Insensitivity Syndrome (AIS), an X-linked disorder caused by mutations in the Androgen Receptor (AR) gene. It is generally accepted that defects in the AR gene prevent the normal development of both internal and external genital structures in 46,XY individuals …
Nikolaos Vitoratos, Georgios Valsamakis, George Mastorakos, Anastassios Boutsiadis, Nikolaos Salakos, Evagelia Kouskouni, George Creatsas
OBJECTIVE: To investigate maternal serum adiponectin and Ιnterleukin-1beta (IL-1β) levels during the pre- and post-partum periods in pregnant women with and without Gestational Diabetes Mellitus (GDM). DESIGN: Thirty control pregnant Caucasian women without GDM and thirty Body Mass Index (BMI) and age-matched Caucasian women with GDM examined in the outpatient clinic between …
Ioanna Dimopoulou, Marinella Tzanela, Dimitra Vassiliadi, Irini Mavrou, Petros Kopterides, Stylianos Orfanos, Anastasia Kotanidou, Styliani Kontogiannopoulou, Spyridon Vasdekis, Iraklis Tsangaris, Apostolos Armaganidis, Anastasios Macheras, Ioannis Ilias, Georgia Kostopanagiotou, Stylianos Tsagarakis
OBJECTIVE: Perioperative pituitary-adrenal responses after major abdominal surgery have not been well characterized. The aim of the present study was to further clarify perioperative pituitary-adrenal responses. DESIGN: Thirty-six patients (20 men), aged 68±10 years (mean±SD), undergoing major abdominal operations were studied …
Eugenia I. Marova, Nikolay P. Goncharov, Galina S. Kolesnikova, Svetlana D. Arapova, Anastasiya M. Lapshina
OBJECTIVE: The purpose of this study was to evaluate the direct action of desmopressin (agonist of vasopressin) on the hypophysis and the three zones of the adrenal cortex in patients with different forms of hypercortisolism. DESIGN: Forty-three patients with hypercortisolism—21 with Cushing’s disease (14 females, 7 males), 11 with extrapituitary …
Thalia Bei, Constantinos Tilkeridis, Stavros Garantziotis, Sosipatros A. Boikos, Konstantinos Kazakos, Constantinos Simopoulos, Constantine A. Stratakis
OBJECTIVE: We recently reported the association of the Sp1 site polymorphism of the COL1A1 gene with lumbar disk disease (LDD). In the present study we searched for a different polymorphism of the COL1A1 gene (which is usually not in linkage disequilibrium with the Sp1 site) in subjects with LDD…
Mehmet Kirnap, Hulusi Atmaca, Fatih Tanriverdi, Osman Ozsoy, Kursad Unluhizarci, Fahrettin Kelestimur
OBJECTIVE: To investigate the hypothalamic-pituitary-adrenal (HPA) axis via the insulin-tolerance test (ITT), standard-dose (250 μg) ACTH test (SDT) and low-dose (1 μg) ACTH test (LDT) in patients with ankylosing spondylitis (AS). DESIGN: The study group included 13 male patients with AS who were diagnosed according to the Modified New York criteria …
Alexandra Chrisoulidou, Kalliopi Pazaitou-Panayiotou, Eleni Georgiou, Maria Boudina, George Kontogeorgos, Ioannis Iakovou, Ioannis Efstratiou, Frideriki Patakiouta, Iraklis Vainas
Ectopic production of CRH by a medullary thyroid carcinoma or its metastases is a rare cause of ectopic Cushing’s syndrome (ECS). We report a 45-year old male with medullary thyroid carcinoma (MTC), who, 24 years following the initial diagnosis …
Stefanie Petzold, Alexandra Keller, Eberhardt Keller, Christof Meigen, Wolfgang Hirsch, Jürgen Kratzsch, Wieland Kiess, Roland Pfäffle
Combined pituitary hormone deficiency (CPHD) is a rare disorder resulting from impaired production of several pituitary hormones. This report describes the 30-year history of a patient who has apparently lived without a pituitary …
Eleanor Roderick, Niki Karavitaki, John AH Wass
The history of the management of craniopharyngiomas offers a comprehensive review of the exciting progress in neurosurgery, neuroimaging, neuroendocrinology and radiation oncology during the last century. In this historical note, we present the evolution in management of these most challenging of brain tumours, which, despite the substantial knowledge and expertise gained since the first attempt of surgical removal, remains a subject of considerable debate…