Dysfunction of the Hypothalamic-Pituitary-Adrenal axis in HIV infection and disease

Evangelia Zapanti, Konstantinos Terzidis, George Chrousos

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Abnormalities of the Hypothalamic-Pituitary-Adrenal (HPA) axis have been documented in HIV patients in the early as well as late stages of the infection and range from subtle subclinical disturbances to frank adrenal insufficiency. Potential etiologies of these disorders include opportunistic infections, neoplasms …

Body composition in asymptomatic HIV-infected men: cross-sectional and prospective assessment

Marios C Lazanas, Irene V Lambrinoudaki, Gerasimos A Douskas, Georgios A Tsekes, Maria N Chini, Evangelos K Georgiou

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Data on body composition changes in HIV infected patients is sparse and controversial. The aim of this study was to assess body composition in asymptomatic HIV-infected men with normal body weight in comparison to healthy HIV-negative control men and to investigate possible body composition changes …

Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy

Vana Spoulou, Christina Kanaka-Gantenbein, Irini Bathrellou, Stefano Mora, Glyceria Mostrou, Lambros Sidossis, George Chrousos, Maria Theodoridou

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OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray absorptrometry (DXA) in children with HIV, primarily because reference data for normally growing children and adolescents are not available. Our study aimed at evaluating body composition in children with HIV and their relatiοn to serum lipids and glucose homeostasis …

Novel syndrome of four-limb proximal fragility fractures associated with HIV infection, cholestatic liver failure, and histiocytic infiltration of bone marrow

Run Yu, Nicholas N. Nissen, Bonnie Balzer, Xuemo Fan

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We report a syndrome of four-limb proximal fragility fractures associated with HIV infection, cholestatic liver failure, and histiocytic infiltration of bone marrow in a 40-year-old African American man. The patient presented with multiple fractures in the proximal humeri …