Anna Maria Formenti, Linda Daffini, Ilenia Pirola, Elena Gandossi, Alessandra Cristiano, Carlo Cappelli
Issue 2 (April – June)142
Androgens as double-edged swords: Induction and suppression of follicular development
Jie-Xue Pan, Jun-Yu Zhang, Zhang-Hong Ke, Fang-Fang Wang, John A. Barry, Paul J. Hardiman, Fan Qu
Androgens, which are mediated via the androgen receptor (AR), play important roles in normal follicular development and female fertility. However, just like a double-edged sword, besides the positive effects of androgen on follicular development, abnormal androgen levels, especially as in hyperandrogenism, seriously suppress normal follicular development …
Primary hyperparathyroidism and the road to surgery: appraisal of the proceedings of the four international workshops (1990, 2002, 2008, 2014) on primary hyperparathyroidism
Romanos Sklavenitis-Pistofidis, Ourania Papaioannou, Kalliopi Kotsa
Although surgery is unambiguously recommended for symptomatic primary hyperparathyroidism (PHPT) patients, management options for asymptomatic patients have varied between surgery, medications and follow-up. To deal with this issue, four International Workshops have taken place, in 1990, 2002, 2008 and 2014 …
Pregnancy-Induced hypertension
Evangelia Kintiraki, Sophia Papakatsika, George Kotronis, Dimitrios G. Goulis, Vasilios Kotsis
Pregnancy-induced hypertension (PIH) complicates 6-10% of pregnancies. It is defined as systolic blood pressure (SBP) >140 mmHg and diastolic blood pressure (DBP) >90 mmHg. It is classified as mild (SBP 140-149 and DBP 90-99 mmHg), moderate (SBP 150-159 and DBP 100-109 mmHg) and severe (SBP ≥160 and DBP ≥110 mmHg) …
Maternal vitamin D status in pregnancy: a critical appraisal of current analytical data on maternal and neonatal outcomes
Spyridon N. Karras, Panagiotis Anagnostis, Andrea Petroczi, Cedric Annweiler, Declan P. Naughton, Dimitrios G. Goulis
Maternal hypovitaminosis D during pregnancy has been associated with a wide spectrum of adverse maternal and neonatal health outcomes, some manifesting stronger associations than others. Research in this field has entered the “era of systematic data evaluation” via the conducting of a series of meta-analyses in an attempt to synthesize …
NGAL and cystatin C: two possible early markers of diabetic nephropathy in young patients with type 1 diabetes mellitus: one year follow up
Nektraria Papadopoulou-Marketou, Chrysanthi Skevaki, Ioanna Kosteria, Melpomeni Peppa, George P. Chrousos, Ioannis Papassotiriou, Christina Kanaka-Gantenbein
OBJECTIVE: Diabetic nephropathy constitutes a major long-term complication in patients with type 1 diabetes mellitus (T1D) and its diagnosis is based on microalbuminuria. The aim of this observational follow-up study was to explore the role of neutrophil-gelatinase-associated lipocalin (NGAL) and cystatin C in unravelling early diabetic nephropathy even in patients with normoalbuminuria …
Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males
Eva N. Kassi, Spiros Stavropoulos, Panayiotis Kokkoris, Antonis Galanos, Paraskevi Moutsatsou, Cleanthi Dimas, Athanasios Papatheodorou, Christos Zafeiris, George Lyritis
OBJECTIVE: We aimed to determine the prevalence of 25(OH)D (D2 and D3 independently) inadequacy in healthy young/middle-aged men and to investigate its relationship with BMD, bone markers, demographic and lifestyle parameters such as age, BMI, smoking, alcohol consumption and dietary calcium intake …
Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors
Cristiano Roberto Grimaldi Barcellos, Michelle Patrocínio Rocha, Sylvia Asaka Yamashita Hayashida, Wagner Silva Dantas, Viviane dos Reis Vieira Yance, José Antonio Miguel Marcondes
OBJECTIVE: The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation—tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)—in young women without major cardiovascular (CV) risk factors …
Relationship between salivary and serum testosterone levels in response to different exercise intensities
Amy R. Lane, Anthony C. Hackney
The anabolic hormone testosterone (T) continues to be researched extensively in exercise studies, with blood serum or plasma samples collected routinely. This method is considered both valid and reliable; however, the collection process can be invasive and difficult during exercise …
Gonadotropin releasing hormone analog treatment in children with congenital adrenal hyperplasia complicated by central precocious puberty
Ayla Güven, Ayşe Nurcan Cebeci, Suna Hancili
OBJECTIVE: Congenital adrenal hyperplasia (CAH) can be complicated by central precocious puberty (CPP) in children, which may compromise final height. We aimed to evaluate the effect of gonadotropin-releasing hormone analog (GnRHa) therapy on growth in children with CAH …
Human kallikrein 10 in surgically removed human pituitary adenomas
Fabio Rotondo, Antonio Di Ieva, Kalman Kovacs, Michael D. Cusimano, Luis V. Syro, Eleftherios P. Diamandis, George M. Yousef
OBJECTIVE: Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors …
Does metformin have a “buffer effect” on serum TSH levels in euthyroid diabetic patients?
Silvia Santos-Palacios, Antonio Brugos-Larumbe, Francisco Guillén-Grima, Ane Garmendia-Madariaga, Juan C. Galofré
OBJECTIVE: In the last few years a number of studies have found that metformin has a thyrotropin (TSH)-lowering effect in patients with type 2 diabetes (DM2) and that this effect disappears after discontinuation of the drug. Initial studies were carried out in hypothyroid patients on levothyroxine (LT4) treatment …
Adult height following a combined treatment of ketoconazole – cyproterone acetate – leuprolide depot in a boy with atypical McCune-Albright syndrome
Maria Francesca Messina, Tommaso Aversa, Luisa de Sanctis, Malgorzata Wasniewska, Mariella Valenzise, Giovanni Battista Pajno, Filippo De Luca, Fortunato Lombardo
BACKGROUND: This study was carried out because of the rarity of peripheral precocious puberty (PPP) in boys with McCune-Albright syndrome (MAS) and the lack of data on adult height of treated MAS males, treatment for this disorder being not as yet standardized …
Olfactory dysfunction in children with Kallmann syndrome: relation of smell tests with brain magnetic resonance imaging
Ahmet Anık, Gönül Çatlı, Ayhan Abacı, Handan Güleryüz, Çağdaş Güdücü, Adile Öniz, Şule Can, Bumin Dündar, Ece Böber
OBJECTIVE: Kallmann syndrome (KS) is a genetic disorder with the distinctive features of hyposmia or anosmia and hypogonadotropic hypogonadism. Though hyposmia/anosmia can be evaluated by both objective and subjective smell tests, there is no study comparing these two methods in KS …
Mitotane and Carney Complex: ten years follow-up of a low-dose mitotane regimen inducing a sustained correction of hypercortisolism
Michela Rosaria Campo, Olga Lamacchia, Anna Farese, Antonella Conserva, Giuseppe Picca, Gianpaolo Grilli, Mauro Cignarelli
OBJECTIVE: Primary pigmented nodular adrenocortical disease (PPNAD), an uncommon cause of Cushing’s syndrome, is frequently associated with a wider clinical spectrum, the Carney complex (CC), a multiple endocrine neoplasia syndrome …
Reversal of impaired counterregulatory cortisol response following diazoxide treatment in a patient with non insulinoma pancreatogenous hypoglycemia syndrome: Case report and overview of pathogenetic mechanisms
Stelios Fountoulakis, Dimosthenis Malliopoulos, Labrini Papanastasiou, Theodora Pappa, George Karydas, George Piaditis
OBJECTIVE: Non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) is one of the rare causes of endogenous hyperinsulinism. Its diagnosis is challenging and may require selective intraarterial calcium stimulation and concomitant hepatic vein sampling (SACVS). Impaired counterregulatory hormones’ production in response to hypoglycemia …
Precocious presentation of autoimmune polyglandular syndrome type 2 associated with an AIRE mutation
Eduarda Resende, Gemma Novoa Gόmez, Marta Nascimento, Lourdes Loidi, Rebeca Saborido Fiaño, Paloma Cabanas Rodrίguez, Lidia Castro-Feijoo, Jesús Barreiro Conde
Autoimmune polyglandular syndrome type 2 (type 2 APS), or Schmidt’s syndrome, is defined by the presence of Addison’s disease in combination with type 1 diabetes and/or autoimmune thyroid disease. The estimated prevalence of this syndrome is 1.4-4.5 per 100,000 inhabitants and it is more frequent in middle-aged females …
Familial partial lipodystrophy type 3: a new mutation on the PPARG gene
Eva Lau, Davide Carvalho, Joana Oliveira, Susana Fernandes, Paula Freitas
Familial partial lipodystrophy is an autosomal dominant genetic disorder characterized by lipoatrophy of the extremities and gluteal region and lipohypertrophy of the face, neck and/or trunk. It is associated with insulin resistance, hypertriglyceridemia and increased risk of recurrent episodes of pancreatitis …
A novel mutation of the calcium-sensing receptor gene in a Greek family from Nisyros
Evaggelia Zapanti, Aikaterini Polonifi, Michalis Kokkinos, George Boutzios, Georgia Kassi, Narjes Nasiri Ansari, Eva Kassi, Aris Polyzos
PURPOSE: Inactivating mutations of the calcium-sensing receptor (CASR) gene cause familial hypocalciuric hypercalcaemia (FHH). Here we report three siblings with FHH caused by a novel mutation in the CASR. METHODS: The case subject was a 60-year-old patient referred because of mild hypercalcaemia …
History of the Cretan cohort of the Seven Countries Study
Christos M. Hatzis, Dimitra Sifaki-Pistolla, Anthony G. Kafatos
It was a great pleasure to read the manuscript of Hatzis CM et al, 2013, published in the Hormones Journal. This article presented the results for cardiovascular risk factors of the Cretan cohort of the Seven Countries Study (SCS) …