Thyroid nodules – Stepwise diagnosis and management

Stergios A. Polyzos, Marina Kita, Avraam Avramidis

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Thyroid nodules are common in clinical practice. They may be solitary within a “normal” thyroid gland or dominant within a multinodular goiter. The incidence of thyroid nodules has been on the rise in recent decades, mainly due to the wider use of neck imaging. Therefore, the incidental finding of a thyroid nodule in an asymptomatic patient is not rare…

Coronary calcification in patients with end-stage renal disease: a novel endocrine disorder?

Georgios Efstratiadis, Konstantinos Koskinas, Efstathios Pagourelias

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Cardiovascular mortality is significantly increased among patients with end-stage renal disease. The commonly observed vascular calcification in such patients has been considered as one of the causative factors. In patients undergoing dialysis, the incidence of coronary artery calcification is 2-5 times higher compared to patients with normal renal function and angiographically demonstrated coronary artery disease…

Endocrine evaluation of patients after brain injury: what else is needed to define specific clinical recommendations?

Gemma Sesmilo, Irene Halperin, Manuel Puig-Domingo

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Brain injury (BI), both head trauma (TBI) and subarachnoid hemorrage (SAH), has consistently been recognized as an important cause of pituitary dysfunction.1 Different studies have estimated that 20-50% of patients who have suffered BI will develop some degree of hypopituitarism.1-9 The high incidence of BI ranks it as potentially the most important cause of hypothalamic-pituitary dysfunction…

Early metabolic defects following gestational diabetes in three ethnic groups of anti-GAD antibodies negative women with normal fasting glucose

Eleni Kousta, Natasha J. Lawrence, Ian F. Godsland, Anna Penny, Victor Anyaoku, Barbara A. Millauer, Stephen Robinson, Desmond G. Johnston, Mark I. McCarthy

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OBJECTIVE: To characterise early metabolic abnormalities and the impact of ethnicity following gestational diabetes mellitus (GDM). DESIGN: Women with a history of GDM belonging to three different ethnic groups were evaluated. Using the insulin-modified, frequently-sampled intravenous glucose tolerance test (FSIVGTT) and HOMA we studied 34 European …

Data on pubertal development in Greek boys. A longitudinal study

Kyratsoula Pantsiotou

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OBJECTIVE: Longitudinal data on boys’ puberty evolution are not available in Greece and very few such studies have been reported world-wide. We present data from a longitudinal study on height, weight, BMI and age at the different pubertal stages in Greek boys. DESIGN: At the start of the study 204 prepubertal boys aged 8-10 years …

A newly detected mutation of the RET protooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2A

Sotirios Bethanis, George Koutsodontis, Theodosia Palouka, Christos Avgoustis, Drakoulis Yannoukakos, Thalia Bei, Savas Papadopoulos, Dimitrios Linos, Stylianos Tsagarakis

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Multiple endocrine neoplasia type 2A (MEN2A) is a syndrome of familial neoplasias characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and hyperplasia of the parathyroid glands. RET protooncogene mutations are responsible for MEN 2A. Mutations in exons 10 or 11 have been identified in more than 96% of patients with MEN 2A…

Diabetes and the “Natural Faculties'” in the Galenic treatises

Niki Papavramidou, Helen Christopoulou-Aletra

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The term diabetes first appears in a text by Aretaeus to describe a disease of the kidneys. Galen is likely to have borrowed this term from Aretaeus also to describe the same disorder, though in a manner somewhat uncharacteristic of his writings. Taken as a whole, only a few mentions may be found in the Galenic writings …