Gonzalo Díaz-Soto, María Teresa Julián, Manel Puig-Domingo
Normocalcemic primary hyperparathyroidism (NCHPT) is a new entity which possibly represents a “fruste form” of classic clinically symptomatic hyperparathyroidism. Over the last decade it has generated considerable scientific interest …
Zoe Iliodromiti, Nikolaos Antonakopoulos, Stavros Sifakis, Panagiotis Tsikouras, Angelos Daniilidis, Kostantinos Dafopoulos, Dimitrios Botsis, Nikolaos Vrachnis
Considering that preterm birth accounts for about 6-10% of all births in Western countries and of more than 65% of all perinatal deaths, elucidation of the particularly complicated mechanisms of labor is essential for determination of appropriate and effective therapeutic interventions …
Nikolaos Pontikides, Spyros Karras, Athina Kaprara, Angeliki Cheva, Argyrios Doumas, Dimitrios Botsios, Aris Moschidis, Elias Efthimiou, John Wass, Gerasimos E. Krassas
BACKGROUND: Parathyroid cysts (PC) are uncommon entities in routine clinical practice. The vast majority are nonfunctioning and are commonly present as asymptomatic nodular cervical lesions. PC should be considered in the differential diagnosis of an asymptomatic neck mass …
Athanasios D. Anastasilakis, Stergios A. Polyzos, Polyzois Makras, Lampros Kampas, Rosalia-Maria Valeri, Kyriakoulis Dimitrios, Thomas Zarampoukas, Maria Alevizaki
Papillary thyroid microcarcinomas (PTMCs) have an excellent prognosis, although a few may metastasize to cervical lymph nodes. However, an infiltrated palpable neck node without evidence of thyroid disease at presentation is uncommon. We report a patient with PTMC presenting …
Emanuele Ferrante, Valentina Morelli, Claudia Giavoli, Giovanna Mantovani, Elisa Verrua, Elisa Sala, Elena Malcmiodi, Silvia Bergamaschi, Eriselda Profka, Elisa Cairoli, Serena Palmieri, Iacopo Chiodini, Andrea-Gerardo Lania, Anna Spada, Paolo Beck-Peccoz
OBJECTIVE: The diagnosis of hypothalamic-pituitary-adrenal insufficiency (HPAI) is a major clinical challenge. The gold standard procedure remains insulin tolerance test (ITT). This study aimed to evaluate the usefulness of standard-dose corticotrophin stimulation test (SDCT) in diagnosing HPAI …
Foteini Malli, Alexandra Bargiota, Kathrin Theodoridou, Zoi Florou, Fotini Bardaka, George N. Koukoulis, Konstantinos I. Gourgoulianis, Zoe Daniil
OBJECTIVE AND DESIGN: Sarcoidosis has been associated with thyroid diseases. However, until today no definite conclusions have been drawn. We aimed to assess the frequency of thyroid disorders and the levels of thyroid hormones and thyroid antibodies in 68 sarcoidosis patients and 75 controls …
Kleopatra Alexiadou, Alexander Kokkinos, Stavros Liatis, Despoina Perrea, Nicholas Katsilambros, Nicholas Tentolouris
OBJECTIVE. Previous data suggest that apelin and visfatin play a role in metabolism and glucose homeostasis. The aim of the present study was to determine differences in plasma apelin and visfatin concentrations between healthy subjects and patients with type 1 diabetes mellitus …
Nishikant Damle, Chandrasekhar Bal, Praveen Kumar, Ramamohan Reddy, Deepali Virkar
Radioactive iodine uptake (RAIU) is a test used to differentiate hyperthyroidism from thyroiditis and to calculate the radioiodine dose for treatment of Graves’ disease. We aimed to evaluate the predictive role of 24h RAIU with respect to the outcome of radioiodine therapy in patients with diffuse toxic goiter …
Nicholas Tentolouris, Alexandros Andrianakos, Georgios Karanikolas, Dimitrios Karamitsos, Panagiotis Trontzas, Petros Krachtis, Fotis Christoyannis, Elpiniki Tavaniotou, Zouboulio Nikolia, Evaggelia Kaskani, Leonidas Kontelis, Petros P. Sfikakis
OBJECTIVE: In this cross-sectional epidemiologic study we examined the association between type 2 diabetes mellitus and demographic, clinical, and socioeconomic parameters in large rural, urban and suburban populations of adult Greeks. DESIGN: Of the total target adult population …
Maria K. Poulasouchidou, Dimitrios G. Goulis, Pavlos Poulakos, Gesthimani Mintziori, Apostolos Athanasiadis, Grigorios Grimbizis, Basil C. Tarlatzis
OBJECTIVE: To examine whether the concentrations of maternal serum TSH and free thyroxine (fT4) through pregnancy, the presence of thyroid autoimmunity (TAI) or the dose of levo-thyroxine (LT4) replacement can predict the occurrence of maternal or fetal/neonatal complications in pregnant women …
Jana Phillips, Honey E. East, Sarah E. French, Eugen Melcescu, Robert D. Hamilton, William C. Nicholas, Jonathan F. Fratkin, Andrew D. Parent, Gustavo Luzardo, Christian A. Koch
INTRODUCTION: Malignant prolactinoma is an exceedingly rare endocrine tumor and cannot be diagnosed on histological grounds alone. Similarly to other neuroendocrine tumors such as pheochromocytoma, the mitoses index, Ki-67, p53, and others are utilized in helping understand …
Gianluca Tamagno, Donal O’Shea
The diagnosis of insulinoma is based on universally defined clinical and laboratory parameters (Whipple triad and fasting test). Pre-operative tumor localization is the main challenge in the diagnostic management of insulinomas. The pre-operative and/or intra-operative localization …
Labrini Papanastasiou, Theodora Pappa, Aikaterini Dasou, Efi Kyrodimou, George Kontogeorgos, Christianna Samara, Panagiotis Bacaracos, Athanasios Galanopoulos, George Piaditis
OBJECTIVE: Primary central nervous system (CNS) non-Hodgkin’s lymphoma is a rarely encountered clinical entity. Here we present a case of a primary CNS diffuse large B-cell non-Hodgkin’s lymphoma developed on a previously operated and irradiated pituitary macroadenoma. DESIGN-RESULTS: A 60-year-old woman presented with muscle weakness …
Kalliopi Lampropoulou-Adamidou, George Trovas, Ioannis P. Stathopoulos, Nikolaos A. Papaioannou
OBJECTIVE: Pregnancy- and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in primagravid women and the prominent clinical feature of PLO is severe and prolonged back pain and height loss. The prevalence and aetiology of this disorder …
Alexandra Efthymiadou, Eunice G. Stefanou, Dionisios Chrysis
45,X/46,XY mosaicism is associated with a broad spectrum of phenotypes ranging from apparently normal male development to individuals with incomplete sexual differentiation and clinical signs of Turner syndrome in both males and females. The most common presentation among individuals …
Wan-Ting Tsai, Yen-Lin Chen, Wei-Shiung Yang, Hong-Da Lin, Chih-Cheng Chien, Ching-Ling Lin
Reports associating hypokalemic rhabdomyolysis with primary aldosteronism are rare. Hypokalemia does not develop in every patient with primary aldosteronism, and hypokalemic rhabdomyolysis is even rarer in patients with primary aldosteronism …