Cláudia Nogueira, Selma B. Souto, Eduardo Vinha, Daniel Carvalho-Braga, Davide Carvalho
Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy …
Eirini Lioudaki, Niki G. Mavroeidi, Dimitri P. Mikhailidis, Emmanouel S. Ganotakis
Subclinical hypothyroidism (SCH), defined as elevated serum thyroid-stimulating hormone (TSH) in the presence of normal circulating free thyroxine (FT4) and triiodothyronine (T3), is a relatively common condition. Replacement treatment with levothyroxine is justified only for individuals with TSH levels >10 mIU/l …
Dimitrios N. Kiortsis
BACKGROUND AND OBJECTIVE: Very few drugs are approved for obesity treatment by regulatory agencies. Very recently phentermine/topiramate controlled-release [PHEN/TPM CR; (Qsymia®)] obtained Food and Drug Administration (FDA) approval as an addition to a reduced-calorie diet and exercise …
Georgios Boutzios, John Griniatsos, Nikoletta Dimitriou, Athanassios Zilos, Stavroula Antoniou, Evangelos Felekouras, Gregory Kaltsas
OBJECTIVE: Gastric neuroendocrine neoplasms Type 1 (GEN type 1) are mostly localized indolent tumors, with only a minority developing lymph node or distant metastasis. Although they are usually managed conservatively, large, invasive, recurrent and grade 2 lesions may require surgical treatment …
Alexandra Chrisoulidou, Paschalia K. Iliadou, Eleni Doumala, Lemonia Mathiopoulou, Maria Boudina, Maria Alevizaki, Frideriki Patakiouta, Ekaterini Xinou, Kalliopi Pazaitou-Panayiotou
OBJECTIVE: Thyroglossal duct cyst (TGDC) carcinoma is a rare entity and its management is controversial. The aim of this retrospective study was to: (a) identify patients with TGDC carcinoma followed up in our clinic and (b) study specific characteristics of the disease and their association with thyroid carcinoma …
Theodore Karatzas, Ioannis Vasileiadis, George Charitoudis, Efthimios Karakostas, Sofia Tseleni-Balafouta, Gregory Kouraklis
OBJECTIVE: The extent of thyroidectomy for papillary thyroid microcarcinoma (PTMC) is debatable. This study investigated the rate and predictive factors of bilateral versus unilateral PTMC with the objective of identifying those patients who may benefit from total thyroidectomy …
Eleni P. Kotanidou, Maria G. Grammatikopoulou, Bessie E. Spiliotis, Christina Kanaka-Gantenbein, Maria Tsigga, Assimina Galli-Tsinopoulou
OBJECTIVE: While the US today has the highest rates worldwide of obesity, Europe, and particularly Southern Europe, is catching up fast. The aim of this study was to report the prevalence of obesity in Greek children, aged 1-12 years. DESIGN: A systematic review—including all studies published in English and Greek …
Grigorios Rombopoulos, Magdalini Hatzikou, Dimitra Latsou, John Yfantopoulos
OBJECTIVE: To estimate the impact of hypoglycemia on the Quality of Life (QoL) and its prevalence in patients with type 2 diabetes mellitus (T2DM) in Greece. DESIGN: A cross-sectional epidemiological study was conducted in 6631 patients with T2DM …
Ekaterini Koiou, Konstantinos Tziomalos, Ilias Katsikis, Dimitrios Delkos, Elena A. Tsourdi, Dimitrios Panidis
OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by obesity and insulin resistance (IR), which result in elevated plasminogen activator inhibitor-1 (PAI-1) levels. We aimed to assess the changes in PAI-1 levels in PCOS during treatment with metformin and during weight loss …
Wei Wang, Xiaobo Yang, Jianbo Liang, Ming Liao, Haiying Zhang, Xue Qin, Linjian Mo, Wenxin Lv, Zengnan Mo
Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men …
Shizhang Liu, Zhi Yi, Ming Ling, Jiyuan Shi
OBJECTIVE: Osteoporosis is a serious and common health issue of considerable complexity among postmenopausal women. The osteoprotegerin gene (OPG) is considered to play an important role in the pathogenesis of osteoporosis. The objective of this study was to detect single nucleotide polymorphisms …
Goran Cvijovic, Dragan Micic, Aleksandra Kendereski, Svetlana Zoric, Mirjana Sumarac-Dumanovic, Svetislav Tatic, Aleksandar Trivic, Danica Pejkovic-Stamenkovic, Danka Jeremic
OBJECTIVE: Serum calcitonin (CT) is a sensitive but not specific marker for medullary thyroid carcinoma (MTC). There are a large number of conditions that may elevate CT levels. CASE REPORT: Herein we present the case of a 47-year old woman with Hashimoto thyroiditis …
Kalliopi Lampropoulou-Adamidou, Symeon Tournis, Alexia Balanika, Ioulia Antoniou, Ioannis P. Stathopoulos, Christos Baltas, Ioannis K. Triantafillopoulos, Nikolaos A. Papaioannou
OBJECTIVE: Despite the existence of numerous case series, no evidenced-based medical management for atypical fractures associated with bisphosphonate (BP) treatment has been established. DESIGN: We report the outcome of teriparatide (TRP) administration followed …
Claudia Battista, Raffaella Viti, Salvatore Minisola, Iacopo Chiodini, Vincenzo Frusciante, Alfredo Scillitani, Vincenzo Carnevale
OBJECTIVE: To describe the biochemical effects of an over-supplementation of vitamin D3 in two patients with primary hyperparathyroidism (PHPT). DESIGN: Two patients (A and B) with PHPT took erroneously 2,400,000U …
Emmanouela Papadaki
In a recent article, three case reports of familiar isolated primary hyperparathyroidism due to HRPT 2 mutation are presented. For the detection the authors used laboratory tests, u/s and nuclear medicine imaging techniques …