Athanasios N. Tsartsalis, Charalambos Dokos, Georgia D. Kaiafa, Dimitris N. Tsartsalis, Antonios Kattamis, Apostolos I. Hatzitolios, Christos G. Savopoulos
Osteoporosis is a major health problem affecting both men and women. Statins, besides their action as lipid-lowering agents, seem to have additional pleiotropic properties, among them a beneficial effect on bone mineral density. The entirety of experimental and the majority of clinical studies …
Lampros Fotis, Dionysios Giannakopoulos, Lela Stamogiannou, Maria Xatzipsalti
In 1995 David Barker formulated the ‘Barker hypothesis’ according to which there is a correlation between undernutrition in utero and several diseases in adult life. More specifically, undernutrition in utero permanently affects the vascular bed, resulting in a predisposition to diseases later on …
Stergios A. Polyzos, Athanasios D. Anastasilakis, Georgios Arsos
Fine needle biopsy (FNB) is regarded as the method of choice in the management of thyroid nodules because of its simplicity, reliability, accuracy and cost-effectiveness. Indeed, the use of FNB has halved the number of patients undergoing thyroidectomy …
Victoria Salem, Thomas G. Hopkins, Heba El-Gayar, Sagen Zac-Varghese, Anthony P. Goldstone, Jeannie F. Todd, Waljit Dhillo, Benjamin C.T. Field, Niamh Martin, Emma Hatfield, Mandy Donaldson, Fausto Palazzo, Karim Meeran, James Jackson, Tricia Tan
CONTEXT: Adrenal vein sampling (AVS) is recommended in all patients with hyperaldosteronism to whom surgery would be offered if the results indicated unilateral hypersecretion. OBJECTIVE: To assess the performance of AVS against radiological findings …
Spiridon Dimas, Spiridon Michas, Ioannis Christakis, Christos Augoustis, Maria Alevizaki
OBJECTIVE: Previous neck surgery (PNS) in patients with primary hyperparathyroidism (PHP) is considered as a contraindication for minimally invasive parathyroidectomy (MIP). The purpose of our study was to determine the effectiveness of MIP in such patients …
Eugen Melcescu, Michael Griswold, Lianbin Xiang, Sheila Belk, Denise Montgomery, Marilyn Bray, Kevin S. Del Ben, Gabriel I. Uwaifo, Gailen D. Marshall, Christian A. Koch
OBJECTIVE: Polymorphisms (SNP) in the glucocorticoid receptor (GR) gene can alter sensitivity to glucocorticoids. Previous studies of the N363S and BclI SNP in the GR gene have shown a metabolic syndrome phenotype in mostly non-African populations. The obesity phenotype of African Americans …
Georgios A. Christou, Constantinos C. Tellis, Moses S. Elisaf, Alexandros D. Tselepis, Dimitrios N. Kiortsis
OBJECTIVE: The investigation of the relationship between high density lipoprotein (HDL) and adiponectin. DESIGN: Thirty-seven obese or overweight [body mass index ≥27 Kg/m2], hypertriglyceridemic patients underwent one of the following interventions for 3 months …
Mirjana Doknic, Sandra Pekic, Milorad Civcic, Vera Popovic
CONTEXT: Congenital hypopituitarism is a syndrome which is associated with single or multiple pituitary hormone deficiencies. Mutations in a number of developmental genes have been linked to combined pituitary hormone deficiencies, the most common being mutation in the pituitary …
Olga Karapanou, Marinella Tzanela, Nikolaos Tamouridis, Stylianos Tsagarakis
We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH …
Run Yu, Nicholas N. Nissen, Bonnie Balzer, Xuemo Fan
We report a syndrome of four-limb proximal fragility fractures associated with HIV infection, cholestatic liver failure, and histiocytic infiltration of bone marrow in a 40-year-old African American man. The patient presented with multiple fractures in the proximal humeri …
Gonzalo Díaz-Soto, Maria J. Vaquerizo, Ciro García-Alvarez, Aurelia Villar-Bonet
A 45-year-old woman, with a history of asymmetric facial flushing, was presented to the Endocrinology Unit after pituitary macroadenoma removal. After other pathological entities had been ruled out, she was diagnosed with harlequin syndrome following a lesion of the postganglionic …
Vasiliki Daraki, Sofia Koukouraki, George Velegrakis, Evangelia Mamalaki, Vrettos T. Haniotis, George Kalikakis, Maria I. Stathaki, Nikos Karkavitsas, Stathis S. Papavasiliou
OBJECTIVE: To describe a rare case of occult (<1cm in diameter) medullary thyroid carcinoma (MTC) in a 45-year-old woman, presenting as an asymptomatic mediastinal mass. DESIGN: The diagnostic methodology included laboratory measurements of relevant biochemical and hormonal parameters ...
Vasiliki Vasileiou, Anastasia K. Armeni, Apostolos L. Pierris, Neoklis A. Georgopoulos
In the literature of the Roman Era, a case of macrosomia and genital ambiguity in a newborn is described. Textual evidence concerning this case of androgynism and its symbolism is provided in the present study. Medical interpretation of such cases covers the entire spectrum …
Ioannis Ilias, Filio Spanoudi, Eftychia Koukkou, Stamatina C. Nikopoulou
The creators of the FRAX fracture risk calculator for countries with no national reference values (such as Greece) suggest the use of FRAX from a neighboring country. For Greeks (considered to run a high risk for osteoporotic fractures) …