Hermaphroditism in Greek and Roman antiquity

George Androutsos

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Since antiquity hermaphrodites have fascinated the mind and excited the imagination. In this paper, such subjects are discussed as legends about the nativity of Hermaphroditus, son of Hermes and Aphrodite, the social status of these bisexual beings, and their fate in Greek-Roman antiquity…

Calciphylaxis: a complication of end-stage renal disease improved by parathyroidectomy

John C. Maroulis, Constantinos Fourtounas, John G. Vlachojannis, Nikolaos Siasos, Dionysios Karavias, Dionysios Chartoumpekis, Ioannis Habeos

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A 43-year old Caucasian male with end-stage renal disease presented with painful skin lesions and high calcium phosphate product that did not respond to medical treatment. Skin biopsy confirmed the diagnosis of calciphylaxis. Urgent parathyroidectomy was performed and re­sulted in decrease in the calcium phosphate product and improvement of his symptoms and signs …

The use of insulin sensitising agents in ovulation induction in women with Polycystic Ovary Syndrome

Richard Fleming

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Insulin resistance is an important “upstream” driver for reproductive and metabolic abnormalities in women with Polycystic Ovary Syndrome (PCOS). This theoretical background is now supported by substantial evidence for treating women with PCOS with insulin sensitising agents such as metformin or the thiazolidinediones…

Thyroid Nodules 2006: Managing what has been known for over 50 years

Jeffrey R. Garber

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The 50th anniversary of the publication of Mortensen, Woolner and Bennet’s paper entitled Gross and microscopic findings in clinically normal thyroid glands has just passed. 1 Their paper reported that at autopsy at the Mayo Clinic approximately half of those not known to have thyroid disease pre-mor­tem had thyroid nodules …

Plasma Interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors

Maria Bougoulia, Athanassios Triantos, George Koliakos

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OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and iso­prostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obese women of reproductive age (group A: age (mean ±SD) 35.4 ± 9.2 years, Body Mass Index (BMI) 38.5±7 kg/m2) and 30 healthy, normal weight women …

Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adults

Dragana Miljic, Predrag Miljic, Mirjana Doknic, Sandra Pekic, Marina Djurovic, Milica Colovic, Vera Popovic

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BACKGROUND: In rodents, Growth Hormone (GH) has been shown to stimulate coagulation parameters, including Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT) and vitamin K dependent coagulation factors. However, there are no reports on the influence of GH replacement therapy on global coagulation tests in Growth Hormone Deficiency (GHD)…

R831X mutation of the androgen receptor gene in an adolescent with Complete Androgen Insensitivity Syndrome and bilateral testicular hamartomata

Dimitrios G. Goulis, Paschalia K. Iliadou, Athanasios Papanicolaou, Ioannis Georgiou, Anthi Chatzikyriakidou, Spiridon Gerou, Ioannis N. Bontis, Ioannis Papadimas

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An 18-year old, phenotypically female individual was examined for primary amenorrhea. Three months before her referral, the patient underwent surgery and a pelvic mass was removed. The physical examination revealed normal female external genitalia, normal breast develop­ment, sparse pubic hair and absence of axillary hair…

A boy with McCune-Albright syndrome associated with GH secreting pituitary microadenoma. Clinical findings and response to treatment

Maria Papadopoulou, Sofia Doula, Kostas Kitsios, Themistoklis Kaltsas, Konstantina Kosta

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The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Albright. MAS is characterized by a triad of physical signs: café-au-lait spots, polyostotic fibrous dysplasia and autonomous endocrine hyperfunction. MAS is predominantly observed in girls and is rarely reported in males…