Category: Issue 1 (January-March)61

Subclinical hyperthyroidism of variable etiology and its influence on bone in postmenopausal women

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Zhanna E. Belaya, Galina A. Melnichenko, Ljudmila Y. Rozhinskaya, Valentin V. Fadeev, Tatjana M. Alekseeva, Olga K. Dorofeeva, Natalja I. Sasonova, Galina S. Kolesnikova

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OBJECTIVE: To evaluate the effects of subclinical hyperthyroidism of variable etiology on bone mineral density (BMD) and bone metabolism in postmenopausal women. DESIGN: T he study included data of 88 postmenopausal women classified into four groups depending on the etiology of subclinical hyperthyroidism: (1) 20 with toxic multinodular goiter without history of clinical hyperthyroidism …

Pubertal arrest due to Zn deficiency The effect of zinc supplementation

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Zuleyha Karaca, Fatih Tanriverdi, Selim Kurtoglu, Serife Tokalioglu, Kursad Unluhizarci, Fahrettin Kelestimur

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The Prasad S yndrome is characterized by iron deficiency anemia, hepatosplenomegaly, skin changes, hypogonadism, dwarfism and geophagia. Hypogonadism is a major manifestation of zinc (Zn) deficiency in both humans and animals. T he mechanism of hypogonadism caused by Zn deficiency has not been clarified…

Thyroid tuberculosis

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Konstantinos Terzidis, Panagoula Tourli, Erasmia Kiapekou, Maria Alevizaki

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Although the association of thyroid disorders with tuberculosis has been known for a long time, the diagnosis of thyroid tuberculosis is rare. Differential diagnosis can be very difficult without fine needle aspiration. The clinical course of the disease may resemble toxic goiter or acute thyroiditis or may follow a subacute or chronic pattern without specific symptomatology…

Endocrinology in ancient Sparta

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Ioannis N. Tsoulogiannis, Demetrios A. Spandidos

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This article attempts to analyze the crucial link between the plant Agnus castus and human health, particularly hormonal status, with special reference to the needs of the society of ancient Sparta. T he ancient Spartans used Agnus both as a cure for infertility and as a remedy to treat battle wounds…

Coronary heart disease in postmenopausal women; the role of endogenous estrogens and their receptors

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Katerina Saltiki, Maria Alevizaki

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Coronary heart disease is the main cause of death in women. Women during reproductive years are at lower risk for coronary heart disease than men but this difference tends to disappear after the menopause. In this article, we briefly review the clinical and experimental data which highlight the protective role of endogenous estrogens in the pathogenesis of coronary heart disease …

The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity

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Stelios Fountoulakis, George Philippou, Agathocles Tsatsoulis

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The thyroid gland is dependent on dietary iodine for the production of thyroid hormones, normal iodine requirement being about 150-200μg/day. Long-term deficiency in iodine intake is associated with the development of goiter. When the prevalence of goiter in a population rises above 5-10%, the problem is considered endemic …

PvuII and XbaI polymorphisms of the estrogen receptor gene and bone mineral density in a Bulgarian population sample

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Jivka T. Ivanova, Polet B. Doukova, Mihail A. Boyanov, Plamen R. Popivanov

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OBJECTIVE: the aim of this study was to search for a possible association of low bone mineral density (bMD) with the PvuII and XbaI polymorphisms of the estrogen receptor (Er) gene in bulgarian women. DESIGN: 400 bulgarian women participated in this study. bMD was mea-sured at the lumbar spine, femoral neck and at the distal forearm. two groups were identified …

Role of color Doppler ultrasonography in the preoperative management of cold thyroid nodules

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Emmanuel Varverakis, Evaggelos Neonakis, Maria Tzardi, Emmanuel Chrysos

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OBJECTIVE: To evaluate the application of color flow Doppler (CFD) sonography in the preoperative management of benign and malignant cold thyroid nodules. DESIGN: Eighty-five patients with a cold thyroid nodule larger than 1cm were examined with CFD sonography prior to thyroidectomy. The histological examination revealed that 18 (21%) patients had malignant nodules …

Modulation of monocytic lipopolysaccharide-induced tissue factor expression and tumor necrosis factor alpha release by estrogen and calcitriol

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George Vlotides, Roland Gaertner, Matthias W.A. Angstwurm

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OBJECTIVE: Modulatory effects of estrogens on both the immune and the coagulation system are only partially understood. In severe infections high estrogen levels have been observed both in men and postmenopausal women and are associated with increased mortality. Monocyte-derived tissue factor (TF) expression can activate the coagulation system and worsen the course of severe infection…