Chronic stress, visceral obesity and gonadal dysfunction

Ioannis Kyrou, Constantine Tsigos

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Chronic stress represents a prolonged state of dyshomeostasis caused by intense and frequently imposed stressors. Obesity constitutes a chronic dysmetabolic state, leading progressively to a spectrum of metabolic complications, such as diabetes, dyslipidemia, hypertension and cardiovascular disease. Α growing body of evidence supports the existence of significant interactions between stress and obesity …

Thyroid autoimmunity and miscarriage

Athina Kaprara, Gerasimos E. Krassas

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The relation of thyroid autoimmunity to miscarriage is an important issue that has attracted the interest of many investigators. A number of papers have been published so far, which include healthy women, women with recurrent miscarriage and those undergoing assisted reproductive techniques. Most studies have shown a significant positive association between the presence of thyroid autoantibodies and miscarriage rate…

The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats

Anastasia Sfikakis, Pothitos M. Pitychoutis, Katerina Antoniou, Nikolaos Bikas, Zeta Papadopoulou-Daifoti

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OBJECTIVE: We sought to investigate the impact of emotional and surgical stress applied in two hormonally different estrous-cycle phases as well as the hypothalamic dopaminergic involvement on the rapid compensatory adrenal growth (CAG) and the individual adrenal growth (IAG) in rats. DESIGN: After surgery for left and sham adrenalectomy (Adx) carried out on either diestrus-2 (DE-2) or proestrus (PE) …

Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent

Adeela Shahid, Khalid P. Lone, Sadia Saeed, Muhammad Arslan

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OBJECTIVE: We studied the influence of positive family history (FH) of type 2 diabetes mellitus (T2DM) in male offspring using multiple metabolic and endocrine parameters in order to assess whether one or more of these parameters can be used as indicators for T2DM development later in life. DESIGN: Fifty male subjects with one diabetic parent (ODP) and thirty with both diabetic parents …

Isolated adrenocorticotropin deficiency and flexion contractures syndrome

Vassiliki Syriou, Anestis Moisidis, Nikolaos Tamouridis, Krystallenia I. Alexandraki, Margarita Anapliotou

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We present a 73-year-old man with isolated adrenocorticotropic hormone deficiency and “flexion contractures” syndrome along with a review of the relevant literature. The patient initially presented anorexia, vomiting, arthralgias, malaise, and weight loss, which progressively deteriorated during the subsequent 6 months. He was admitted to the hospital with fever, confusion, severe cachexia, sinus tachycardia, low blood pressure …

Alterations of coagulation in metformin intoxication

Baris Akinci, Serkan Yener, Goksel Bengi, Sena Yesil

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It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery…

Primary tuberculosis of the thyroid gland

Ines Zendah, Hafaoua Daghfous, Sonia Ben Mrad, Fatma Tritar

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Thyroid tuberculosis is a rare disease even in countries in which tuberculosis (TB) constitutes an endemic disorder. The diagnosis is often difficult as the clinical presentation has no distinct characteristics. We report a 47-year-old woman who presented with a painful nodular swelling of the neck, confirmed by physical examination and sweating…

The adrenal glands: a brief historical perspective

Basil Leoutsakos, Agnes Leoutsakos

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There have been numerous references to the existence of the adrenal glands ever since ancient times, with an increasing amount of knowledge being accumulated and recorded from the 16th century on.1 Although it would evidently not be possible to cover the plethora of historical references to these glands, a historical outline is herein undertaken…