Growth and growth hormone secretion in paediatric Cushing’s disease

Martin O. Savage, Helen L. Storr, Ashley B. Grossman, Gerasimos E. Krassas

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Although paediatric Cushing’s disease is rare, it is associated with severe morbidity in childhood and presents a major diagnostic and therapeutic challenge for the paediatric endocrinologist. Growth failure remains an important feature of paediatric Cushing’s disease, both at diagnosis and after successful treatment. However, the development of specific diagnostic tests and important therapeutic advances has contributed …

Growth, pubertal development, skeletal maturation and bone mass acquisition in athletes

Neoklis A. Georgopoulos, Kostas B. Markou, Anastasia Theodoropoulou, George A. Vagenakis, Panagiotis Mylonas, Apostolos G. Vagenakis

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The genetic potentials for growth can be fully expressed only under favourable environmental conditions. Excessive physical training may negatively affect growth, especially during puberty. Sports that require a strict control of energy input in the presence of a high energy output are of particular concern. In gymnastics, a different pattern in skeletal maturation was observed …

Growth velocity and final height in elite female rhythmic and artistic gymnasts

Neoklis A. Georgopoulos, Anastasia Theodoropoulou, Nikolaos D. Roupas, Loredana Rottstein, Athanasios Tsekouras, Panagiotis Mylonas, George A. Vagenakis, Eftychia Koukkou, Anastasia K. Armeni, George Sakellaropoulos, Michel Leglise, Apostolos G. Vagenakis, Kostas B. Markou

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PURPOSE: The aim of this study was to determine the impact of intensive training on adult final height in elite female rhythmic and artistic gymnasts. METHODS: The study included 215 rhythmic gymnasts (RG) and 113 artistic gymnasts (AG) …

Ghrelin and growth hormone serum levels during the clonidine test in children with short stature and variable growth hormone status

Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria G. Grammatikopoulou, George Koliakos, George Varlamis

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Objective: The exact role of ghrelin in the control of growth hormone (GH) secretion has not been completely clarified as yet. The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone …

Increased prevalence of growth hormone deficiency in patients with vernal keratoconjuntivitis; An interesting new association

Stefano Stagi, Neri Pucci, Laura di Grande, Cinzia de Libero, Roberto Caputo, Stefano Pantano, Salvatore Seminara, Maurizio de Martino, Elio Novembre

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INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that mainly affects children living in temperate areas. The notable difference between genders and VKC’s resolution with puberty have persistently suggested a role of hormonal factors in VKC development. …

Growth without growth hormone (GH): A case report

Polyzois Makras, Dimitris Papadogias, Grigoris Kaltsas, Nikolaos Kaklas, Georgios Piaditis

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Growth without growth hormone (GH) has occasionally been described in patients with organic pituitary pathology, and even more rarely in patients with idiopathic pituitary hormone deficiency. The mechanism of growth without GH remains a mystery. We describe a 17-year old male who grew 38.5 cm in height over a 7-year period, despite the fact that he had established panhypopituitarism…