Ioannis P. Stathopoulos, Efstathios G. Ballas, Kalliopi Lampropoulou-Adamidou, George Trovas
While osteoporosis has been traditionally considered as a disease of aging women, it is becoming an increasingly important male health problem, with one in three fragility fractures after the age of 50 years occurring in men …
Solomis Solomou, Márta Korbonits
Ghrelin, an orexigenic protein with a unique lipid chain modification, is considered to be an important gut-brain signal for appetite control and energy balance. The ghrelin receptor, growth-hormone secretagogue receptor type 1a, is able to bind acylated ghrelin. The first recognised effect of ghrelin was the induction of growth hormone …
Maria P. Yavropoulou, Christos Xygonakis, Maria Lolou, Fotini Karadimou, John G. Yovos
Sclerosteosis and Van Buchem disease are two rare bone sclerosing disorders characterized by increased bone mineral density, tall stature and entrapment of cranial nerves due to overgrowth of a highly dense bone. Recent advances in human genetics have revealed the genetic background of these disorders …
Charikleia Christakou, Anastasios Kollias, Christina Piperi, Ilias Katsikis, Dimitrios Panidis, Evanthia Diamanti-Kandarakis
OBJECTIVE: To compare the effects of oral contraceptives (OCPs) and metformin on atherogenic markers, including serum levels of advanced glycated end products (AGEs) and C-reactive protein (CRP), in lean women (Body Mass Index below 25 kg/m2) with polycystic ovary syndrome (PCOS), defined by NIH criteria …
George Vlotides, Ayse Tanyeri, Matilde Spampatti, Kathrin Zitzmann, Michael Chourdakis, Gerald Spöttl, Julian Maurer, Svenja Nölting, Burkhard Göke, Christoph J. Auernhammer
Metformin is a widely used oral antidiabetic drug with good tolerability. Recent studies suggest that it also possesses adjuvant potent anticancer properties in a variety of tumors. Neuroendocrine tumors (NETs) of the gastro-entero-pancreatic system (GEP) comprise a heterogeneous group of tumors with increasing incidence …
Efi Koloverou, Nikolaos Tentolouris, Chryssa Bakoula, Christina Darviri, George Chrousos
OBJECTIVE: Although there is scientific evidence that stress adversely affects metabolic control, only a few studies have examined the role of stress management in improving glycemic control in patients with type 2 diabetes mellitus (DM). In this study, we investigated the effect of a relaxation technique on levels of stress and glycemic control …
Stergios A. Polyzos, Dimitrios G. Goulis, Jannis Kountouras, Gesthimani Mintziori, Panagiotis Chatzis, Efstathios Papadakis, Ilias Katsikis, Dimitrios Panidis
OBJECTIVE: Insulin resistance contributes to the pathogenesis of both polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). The main aim of the present study was the evaluation of non-invasive indices of hepatic steatosis and fibrosis in PCOS women with or without metabolic syndrome …
Venkat N. Vangaveti, Catherine Rush, Linda Thomas, Roy R. Rasalam, Usman H. Malabu, Scott G. McCoombe, Richard L. Kennedy
OBJECTIVE: Stromal cell-derived factor-1 (SDF-1) is expressed in pre-adipocytes but its role is unknown. We investigated butyrate (a histone deacetylase inhibitor – HDACi) and other short-chain fatty acids (SCFA) in the regulation of SDF-1. We further investigated whether effects of SCFA were signalled through G protein-coupled receptors …
Maria G. Grammatikopoulou, Eleni P. Kotanidou, Anastasia G. Markaki, Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria Tsigga, Maria Hassapidou
OBJECTIVE: The aim of the present study was to evaluate by pooled and sensitivity analyses all available data on adolescent overweight/obesity in Cyprus. DESIGN: A thorough literature search determined the studies to be examined using Cypriot adolescent samples …
Stefano Stagi, Elisabetta Lapi, Marilena Pantaleo, Giovanna Traficante, Sabrina Giglio, Salvatore Seminara, Maurizio de Martino
OBJECTIVE:SOX3 is located on the long arm of the X chromosome (Xq27.1) and both the under- and over-expression of this gene have been reported in cases of hypopituitarism with or without intellectual disabilities. Nevertheless, only a few cases have as yet been extensively described …
Stefano Stagi, Cristina Manoni, Valentina Cirello, Danila Covelli, Sabrina Giglio, Francesco Chiarelli, Salvatore Seminara, Maurizio de Martino
The syndrome of resistance to thyroid hormone (RTH) is characterized by elevated serum free thyroid hormones (FT4 and FT3) in the presence of unsuppressed TSH levels, reflecting resistance to the normal negative feedback mechanisms in the hypothalamus and pituitary …
Ali A. Ghazi, Ali Mosaddegh Khah, Fereshteh Kamani, Khandan Zare, Alireza Sadeghipour, Mehdi Hedayati, Marjan Zarif Yeganeh, Treena Cranston, Ashley Grossman
Succinate Dehydrogenase-B (SDH-B) gene mutations constitute one of the most frequent forms of hereditary paragangliomas (PGL). Genetic study is advised in all cases for the evaluation of tumour behaviour, the selection of optimal management and the surveillance of the first degree relative …
Marco Mendola, Alessia Dolci, Lanfranco Piscopello, Giustino Tomei, Dario Bauer, Sabrina Corbetta, Bruno Ambrosi
We describe a patient affected by Cushing’s disease due to the presence of double pituitary adenomas, one located within the anterior pituitary and the other in the infundibulum associated with a remnant of Rakthe’s pouch. Cure was achieved only after the infundibulum lesion was surgically removed …
Anastasia K. Armeni, Vasiliki Vasileiou, George Markantes, Christina Damoulari, Angelina Mandrapilia, Fotini A. Kosmopoulou, Varvara Keramisanou, Danai Georgakopoulou, Neoklis A. Georgopoulos
Cases of sexual reassignment in Greco-Roman antiquity, presenting as a pubertal female-to-male gender transformation, are described in the “classical” literature. Textual evidence concerning a case of androgynism, garnered by Diodorus Siculus, among other similar accounts …
Francesco Vierucci, Graziano Cesaretti
Autoimmune thyroiditis is considered to be the most common autoimmune condition, with a female preponderance of 2:1. While its overall prevalence peaks in adulthood, autoimmune thyroiditis may affect children and adolescents, particularly during early to mid-puberty …
Valeria Alcantara-Aragon, Silvia Martinez-Couselo, Diana Tundidor-Rengel, Susan M. Webb, Gemma Carreras, Juan J. Espinos, Ana Chico, Francisco Blanco-Vaca, Rosa Corcoy
Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases, with an estimated prevalence of 1 in 1000. It may manifest at different stages in life. In late childhood, it may present with advanced skeletal maturation …
Christos M. Hatzis, Christopher Papandreou, Dimitra Sifaki-Pistolla, Christine Jildeh, Anthony G. Kafatos
In Greece as well as worldwide, studies on the prevalence of metabolic syndrome (MetS) in children/adolescents began to take place in the second half of the 20th century. It was indicated that the prevalence of MetS is mostly predicted by the presence of obesity and particularly abdominal obesity …