Antje Körner, Susann Blüher, Thomas Kapellen, Ante Garten, Jürgen Klammt, Jürgen Kratzsch, Wieland Kiess
Body weight is regulated by a feedback loop in which peripheral signals report nutritional information to an integratory center in the brain. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centered in the hypothalamus…
Adeeb Shehzad, Waqas Iqbal, Omer Shehzad, Young Sup Lee
Adiponectin is a white and brown adipose tissue hormone, also known as gelatin-binding protein-28 (GBP28), AdipoQ, adipocyte complement-related protein (ACRP30), or apM1. Adiponectin circulates in the bloodstream in trimeric, hexameric, and high-molecular-mass species, while different forms of adiponectin …
Anastasia Markaki, Emmanuel Psylinakis, Aspasia Spyridaki
Adiponectin (ADPN) is an adipokine with significant anti-inflammatory, insulin-sensitizing and anti-atherogenic properties, which is generally associated with a beneficial cardiometabolic profile. Paradoxically, end-stage renal disease (ESRD) is characterized by markedly increased plasma ADPN levels and increased cardiovascular risk. In spite of the cardioprotective properties …
Maria Bougoulia, Athanassios Triantos, George Koliakos
OBJECT IVE: T he aim of this study was to evaluate the levels of adipose tissue related hormones, cytokines, and antioxidative substances in obese women before and after intervention with diet alone or with diet plus an inhibitor of gastrointestinental lipase-orlistat…
Nikolaos Vitoratos, Georgios Valsamakis, George Mastorakos, Anastassios Boutsiadis, Nikolaos Salakos, Evagelia Kouskouni, George Creatsas
OBJECTIVE: To investigate maternal serum adiponectin and Ιnterleukin-1beta (IL-1β) levels during the pre- and post-partum periods in pregnant women with and without Gestational Diabetes Mellitus (GDM). DESIGN: Thirty control pregnant Caucasian women without GDM and thirty Body Mass Index (BMI) and age-matched Caucasian women with GDM examined in the outpatient clinic between …
Themistoklis N. Spyridopoulos, Eleni Th. Petridou, Nick Dessypris, Agapios Terzidis, Alkistis Skalkidou, Charalambos Deliveliotis, George P. Chrousos and the Obesity and Cancer Oncology Group*
OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity. Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk …
Themistoklis N. Spyridopoulos, Nick Dessypris, Antonis G. Antoniadis, Spyros Gialamas, Constantine N. Antonopoulos, Konstantina Katsifoti, Hans-Olov Adami, George P. Chrousos, Eleni Th. Petridou, and the Obesity and Cancer Oncology Group
OBJECTIVE: Obesity and diabetes are considered risk factors for Renal Cell Carcinoma (RCC). We aimed to explore whether insulin resistance (IR) plays an independent role in the development of RCC. DESIGN: In a hospital-based case-control study, we analyzed serum glucose …
Georgios A. Christou, Constantinos C. Tellis, Moses S. Elisaf, Alexandros D. Tselepis, Dimitrios N. Kiortsis
OBJECTIVE: The investigation of the relationship between high density lipoprotein (HDL) and adiponectin. DESIGN: Thirty-seven obese or overweight [body mass index ≥27 Kg/m2], hypertriglyceridemic patients underwent one of the following interventions for 3 months …
Nikolaos D. Roupas, Irene Mamali, Spyros Maragkos, Lydia Leonidou, Anastasia K. Armeni, George K. Markantes, Athanasios Tsekouras, George C. Sakellaropoulos, Kostas B. Markou, Neoklis A. Georgopoulos
OBJECTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners …
Sadashiv, Sunita Tiwari, Bhola Nath Paul, Sandeep Kumar, Abhijit Chandra, S. Dhananjai, Mahendra Pal Singh Negi
OBJECTIVE: The present study evaluates adiponectin mRNA in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and also evaluates its association with metabolic risk factors in postmenopausal obese women. DESIGN: A case control study was carried out on postmenopausal women …