Serum interleukin-22 (IL-22) is increased in the early stage of Hashimoto’s thyroiditis compared to non-autoimmune thyroid disease and healthy controls

Rosaria Maddalena Ruggeri, Paola Minciullo, Salvatore Saitta, Salvatore Giovinazzo, Rosaria Certo, Alfredo Campennì, Francesco Trimarchi, Sebastiano Gangemi, Salvatore Benvenga

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OBJECTIVE: Hashimoto’s thyroiditis (HT) is considered to be a Th1-related autoimmune disease (AID). Recent studies revealed that Th17 lymphocytes (producing mostly IL-17, IL-21 and IL-22) play a major role in numerous AIDs commonly thought to be Th1 diseases. More recently, another subset of Th cells …

Time for the endocrinologists to expand their awareness of and contribution to the diagnosis and management of encephalopathy associated with autoimmune thyroid disease

Gianluca Tamagno, Gadintshware Gaoatswe

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Encephalopathy associated with autoimmune thyroid disease is a rare condition presenting in the setting of autoimmune thyroid disease and characterized by unspecific neurological and/or psychiatric symptoms. Bearing in mind the currently prevailing lack of consensus on the most appropriate nomenclature and diagnostic criteria for this condition and the implications …

Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in Lower Silesia, Poland

Teresa Zak, Anna Noczýnska, Renata Wasikowa, Urszula Zaleska-Dorobisz, Anna Golenko

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The aim of the study was to analyze data related to chronic autoimmune thyroid disease at diagnosis and at follow-up of children and adolescents in Lower Silesia in the years 1999-2004. Age, gender, incidence of thyroid disease in the family, clinical presentation, hormonal findings, levels of thyroid antibodies, results of ultrasonography, and fine needle aspiration biopsy (FNAB) were recorded …

Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Dohee Kim

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OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients …

Iodine content of thyroglobulin in NOD.H2h4 mice developing iodine-accelerated autoimmune thyroiditis

Panayota Kolypetri, Natasha A. Noel, Karen A. Carayanniotis, George Carayanniotis

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OBJECTIVE: In NOD.H2h4 mice, high dietary iodine intake has been known to cause Iodine-accelerated Spontaneous Autoimmune Thyroiditis (ISAT) via an unknown mechanism. The aim of the study was to examine whether the NOD.h4 genetic background predisposes to enhanced iodine organification in thyroglobulin …