Where postmenopausal hormone therapy stands today

Amos Pines

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A dramatic change has occurred over the past decade with regard to the use of hormones during the postmenopausal period. In the 90’s, the belief in the USA being that there was reason to recommend hormone therapy (HT) for the prevention of coronary artery disease, the guidelines of the American College of Physicians in 1992 were as follows …

The role of estrogens in cardiovascular disease in the aftermath of clinical trials

Lambrini Gouva, Agathocles Tsatsoulis

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The effects of estrogens on reproductive tissues and climacteric symptoms are unambiguous. However, their effects on other tissues and, in particular, the cardiovascular system remain controversial. In general, premenopausal women are protected from coronary heart disease (CHD) compared with aged-matched men but this `female protection’ appears to be lost after menopause, suggesting beneficial effects of female sex hormones on the cardiovascular system…

TSH and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with L-thyroxine alone or in combination with L-triiodothyronine

Valentin V. Fadeyev, Tatiana B. Morgunova, Julia P. Sytch, Galina A. Melnichenko

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The aim of this study was to evaluate parameters of thyroid function in patients with primary hypothyroidism receiving either monotherapy with L-T4 or combination L-T4+L-T3. Fifty-eight women with primary hypothyroidism receiving L-T4 were enrolled in the study. The patients were randomised into two groups: Group 1 (n=42) patients continued monotherapy with L-T4, and Group 2 …

Continuous combined replacement therapy in postmenopausal women: effect on plasma lipoproteins, bone mass and the endometrium

Odysseas Gregoriou,George Christodoulakos, Charalambos Siristatidis, Socrates Conidaris, Evangelia Kouskouni, George Creatsas

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Objective: The purpose of this study was to examine the effects of Hormone Replacement Therapy (HRT) on plasma lipoprotein levels, bone mass and the endometrium. Methods: Thirty healthy women were enrolled in the study for climacteric symptoms and received a combination of 17β-estradiol and norethisterone acetate continuously for 2 years …