Category: Issue 3 (July-September)63
Brunner’s missing “Aha experience” delayed progress in diabetes research by 200 years
Fritz S. Keck, Leonidas H. Duntas
In 1889, the pancreatectomy performed on a dog by Joseph von Mehring and Oskar Minkowski led to the discovery of the pancreatic origin of diabetes disease. Already 200 years before, Johann Conrad Brunner had successfully performed eight pancreatectomies on dogs and had precisely described the symptoms of polyphagia, polyuria, and polydipsia…
Management of thyroid nodules in children and adolescents
Wilmar M. Wiersinga
Thyroid nodules in childhood and adolescence are less prevalent but more often malignant than in adulthood. Malignant nodules are predominantly papillary cancers; benign nodules are mostly solid colloid nodules/adenomas, but can be cystic or due lymphocytic thyroiditis…
Differentiated thyroid cancer in children and adults: same or distinct disease?
Barbara Jarzab, Daria Handkiewicz-Junak
Differentiated thyroid cancer (Dtc) is a rare disease, especially in children. Differences in the biology and clinical course of Dtc in children, when compared with adults, may be related both to pathogenesis as well as to clinical outcome of the disease. In childhood, the thyroid gland exhibits higher susceptibility to the carcinogenetic …
Early onset adiposity: A pathway to polycystic ovary syndrome in adolescents?
Evanthia Diamanti-Kandarakis, Charikleia D. Christakou, Eleni Kandaraki, Krystallenia I. Alexandraki
Polycystic Ovary Syndrome is a heterogenous syndrome of unknown causation commonly associated with obesity. Τhe particular timing of the onset of obesity may be important, since the earlier the onset of obesity the greater the severity of the metabolic and hormonal aberrations …
Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unit
Ioannis Ilias, Konstantinos Stamoulis, Apostolos Armaganidis, Panagiotis Lyberopoulos, Marinella Tzanela, Stylianos Orfanos, Maria Theodorakopoulou, Stylianos Tsagarakis, Ioanna Dimopoulou
OBJECTIVE: To evaluate whether tentative prognostic models for intensive care unit survival of multiple trauma patients could be improved by including endocrine parameters. DESIGN: Prospective study. Patients: Eighty-three male and 11 female multiple trauma patients…
Galectin-3 as a marker distinguishing functioning from silent corticotroph adenomas
Eleni Thodou, Theodore Argyrakos, George Kontogeorgos
OBJECTIVE: Galectin-3 (Gal-3) belongs to the family of carbohydrate-binding proteins with high affinity for galactoside and is involved in many biological processes including cell growth and differentiation, cell adhesion, tumor progression, apoptosis and metastasis. The aim of this study was to disclose differences in the expression of Gal-3 in silent …
Oral bisphosphonate adverse effects in 849 patients with metabolic bone diseases
Athanasios D. Anastasilakis, Dimitrios G. Goulis, Marina Kita, Avraam Avramidis
OBJECTIVE: Bisphosphonates are potent antiresorptive agents used for a spectrum of metabolic bone diseases. The aim of this study was to compare the adverse effects (AEs) of alendronate, etidronate and risedronate prescribed in a non-selected population, attending a single institution on an outpatient basis…
Cushing’s syndrome in pregnancy: Report of a case and review of the literature
Marina Kita, Maria Sakalidou, Athanasios Saratzis, Sarris Ioannis, Avraam Avramides
Cushing’s syndrome (CS) during pregnancy is a rare nosology with only a few cases reported in the literature. Misdiagnosis is common, as the syndrome may be easily confused with preeclampsia or gestational diabetes. CS during pregnancy is usually associated with severe maternal and fetal complications..
Growth hormone deficiency in a patient with autoimmune polyendocrinopathy type 2
Asteroula Papathanasiou, Eleni Kousta, Vasiliki Skarpa, Petros Papachileos, Vasilios Petrou, Charalambos Hadjiathanasiou
Autoimmune polyglandular syndrome (APs) type 2 is characterized by the presence of Addison’s disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus and is rare in children. A 12.5yr old prepubertal boy presented with symptoms related to Addison’s disease and a large goiter. He was euthyroid with positive thyroid antibodies, low cortisol, aldosterone and very high adrenocorticotropin …