Romanos Sklavenitis-Pistofidis, Ourania Papaioannou, Kalliopi Kotsa
Although surgery is unambiguously recommended for symptomatic primary hyperparathyroidism (PHPT) patients, management options for asymptomatic patients have varied between surgery, medications and follow-up. To deal with this issue, four International Workshops have taken place, in 1990, 2002, 2008 and 2014 …
Friedhelm Raue, Karin Frank-Raue
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant tumour syndrome caused by germline activating mutations of the RET proto-oncogene. It has a strong penetrance of medullary thyroid carcinoma (MTC) and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism (MEN2A) within a single patient or family…
Theodore K. Alexandrides, Konstantina Kouloubi, Apostolos G. Vagenakis, Spyros Yarmenitis, Trifon Spyridonidis, Pavlos Vassilakos, Dimitris Apostolopoulos
Parathyroid scintigraphy and high-resolution ultrasonography are frequently used as preoperative localization procedures in primary hyperparathyroidism. However, when thyroid disease coexists, their diagnostic accuracy is probably abated. DESIGN: 56 patients with primary hyperparathyroidism were prospectively evaluated with parathyroid scintigraphy…
Spiridon Dimas, Spiridon Michas, Ioannis Christakis, Christos Augoustis, Maria Alevizaki
OBJECTIVE: Previous neck surgery (PNS) in patients with primary hyperparathyroidism (PHP) is considered as a contraindication for minimally invasive parathyroidectomy (MIP). The purpose of our study was to determine the effectiveness of MIP in such patients …
Marios Papadakis, Natalie Meurer, Theodora Margariti, Anke Meyer, Norbert Weyerbrock, Cornelia Dotzenrath
OBJECTIVE: The coexistence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism (PHPT) is extremely rare. Genetic evidence has demonstrated a causal relationship between FHH and the presence of inactivating mutations in the calcium-sensing receptor gene …
Alfredo Campennì, Rosaria Maddalena Ruggeri, Alessandro Sindoni, Salvatore Giovinazzo, Letterio Calbo, Antonio Ieni, Maurizio Monaco, Giovanni Tuccari, Salvatore Benvenga, Sergio Baldari
Parathyroid carcinoma (PC) is a rare malignancy with an indolent but progressive course. This rare tumour is often difficult to diagnose preoperatively, thus limiting the efficacy of surgery. As long-term survival is largely dependent on the extent of the primary surgical resection …
Claudia Battista, Raffaella Viti, Salvatore Minisola, Iacopo Chiodini, Vincenzo Frusciante, Alfredo Scillitani, Vincenzo Carnevale
OBJECTIVE: To describe the biochemical effects of an over-supplementation of vitamin D3 in two patients with primary hyperparathyroidism (PHPT). DESIGN: Two patients (A and B) with PHPT took erroneously 2,400,000U …
Carlos del Pozo, Luis García-Pascual, Montserrat Balsells, María-José Barahona, Enrique Veloso, Clarisa González, Jordi Anglada-Barceló
Parathyroid carcinoma is an infrequent cause of primary hyperparathyroidism. Although hyperparathyroidism in multiple endocrine neoplasia 1 (MEN1) syndrome is the most common manifestation, parathyroid carcinoma is rare. We report a male patient who was diagnosed at 44 years of age with parathyroid carcinoma in the context of MEN1 syndrome coincident …