Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Grigorios Kotronoulas, Antonios Stamatakis, Fotini Stylianopoulou

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Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms …

Growth hormone treatment in human ageing: benefits and risks

Roberta Giordano, Lorenza Bonelli, Elisa Marinazzo, Ezio Ghigo, Emanuela Arvat

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This paper will focus on the rationale of using Growth Hormone (GH) as an anti-ageing therapy in the healthy elderly with age-related decline in the activity of the GH/IGF-I axis, the so called “somatopause”. Although the age-related decline in the activity of the GH/IGF-I axis is considered to contribute to age-related changes …