Estrogens and brain function

Athina Markou, Theodora Duka, Gordana M. Prelevic

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Cognitive decline is well recognized during ageing but is often accelerated in women after menopause. Studies have shown that there are significant gender differences in brain ageing with significantly greater changes in brain structure, function and metabolism between females and males. Estrogens exert protective effects on neuronal cells in culture but the exact underlying …

Weightlessness and skeleton homeostasis

Konstantinos Ziambaras, Roberto Civitelli, Stathis S. Papavasiliou

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As human beings venture into space in the 21st century, they will be confronted with a “hypodynamic” and thus hostile environment for the bone homeostasis, that could potentially compromise their mobility in general and skeletal strength in particular after landing. From this point of view, space flight studies are especially interesting and intriguing models for scientists…

Advanced glycation end products and diabetic complications: A General overview

Melpomeni Peppa, Helen Vlassara

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Diabetes mellitus, especially type 2 diabetes, is increasing at an alarming rate and is considered as one of the main threats to human health in the 21st century, in both developed and developing nations.1
More than 150 million people currently have diabetes, and twice that number is at high risk of developing diabetes in the next 5-10 years …

Applications of genomic medicine in endocrinology and post-genomic endocrine research

Constantine A. Stratakis

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In the mid 1980’s, two advances revolutionized Medicine in a way that is comparable only to some of the most important events in the approximately 3,000 years of its history. The first was the introduction of the concept of “positional cloning”, i.e. the idea that one can identify genes for human disease though knowing nothing or very little about their function…

Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in Lower Silesia, Poland

Teresa Zak, Anna Noczýnska, Renata Wasikowa, Urszula Zaleska-Dorobisz, Anna Golenko

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The aim of the study was to analyze data related to chronic autoimmune thyroid disease at diagnosis and at follow-up of children and adolescents in Lower Silesia in the years 1999-2004. Age, gender, incidence of thyroid disease in the family, clinical presentation, hormonal findings, levels of thyroid antibodies, results of ultrasonography, and fine needle aspiration biopsy (FNAB) were recorded …

Improved somatic growth following adenoidectomy and tonsillectomy in young children. Possible pathogenetic mechanisms

Harilaos S. Vontetsianos, Spiros E. Davris, George D. Christopoulos, Catherine Dacou-Voutetakis

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The effect of Adenotonsillectomy on somatic growth was studied prospectively in 57, randomly selected children (31 boys, 26 girls), aged 5.03±1.32 (mean±1SD) years. The indication for surgery was adenotonsillar hypertrophy with or without recurrent infections. Weight, height, triceps skinfold thickness, and Body Mass Index …

Of Temples and Plane Trees: the Hippocratic Legacy as Collective Memory

Gerasimos P. Sykiotis, George D. Kalliolias, Christos Terezis, Athanasios G. Papavassiliou

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In the homeland of Hippocrates, the study of the history and philosophy of medicine is remarkably infrequent among medical practitioners. It is excluded from the curricula of the majority of medical schools and from the hobbies and pastimes of most physicians and medical students…