Ulla Feldt-Rasmussen, Åse Krogh Rasmussen
Coexistence of differentiated thyroid cancer (DTC) and thyroid autoimmune diseases could represent a mere coincidence due to the frequent occurrence of autoimmunity, but there may also be a pathological and causative link between the two conditions. The coincidence of DTC with Hashimoto’s disease has been variably reported …
Giulia Cogni, Luca Chiovato
Autoimmune diseases are a group of heterogeneous disorders characterized by abnormal lymphocytic activation directed against self-tissues. Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are two of the most common clinical expressions of organ-specific autoimmunity …
Nikolaos Pontikides, Gerassimos E. Krassas
Both smoking and thyroid dysfunction are frequent in the general population. Many studies have shown that cigarette smoking interferes with thyroid function and with the evolution of thyroid pathology (e.g. goiter formation and thyroid cancer development). Some studies have also suggested a significant correlation of Graves’ hyperthyroidism and Graves’ ophthalmopathy…
Spyros Karras, Themistoklis Tzotzas, Gerasimos E. Krassas
Antithyroid drugs (ATD) are widely used by endocrinologists all over the world for the treatment of Graves’ disease (GD) in the general population and in lactating thyrotoxic mothers.1,2 Traditionally, these agents produce minor side effects (rash, fever, urticaria) in 5-10% of the treated patients …
Gianluca Tamagno, Gadintshware Gaoatswe
Encephalopathy associated with autoimmune thyroid disease is a rare condition presenting in the setting of autoimmune thyroid disease and characterized by unspecific neurological and/or psychiatric symptoms. Bearing in mind the currently prevailing lack of consensus on the most appropriate nomenclature and diagnostic criteria for this condition and the implications …
Dohee Kim
OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients …
Tommaso Aversa, Mariacarolina Salerno, Giorgio Radetti, Maria Felicia Faienza, Lorenzo Iughetti, Andrea Corrias, Barbara Predieri, Alessandro Mussa, Silvestro Mirabelli, Filippo De Luca, Malgorzata Wasniewska
BACKGROUND: Studies concerning presentation and evolution over time of Hashimoto’s thyroiditis (HT) in children with Down’s syndrome (DS) are few, are based on limited study populations and do not include control HT groups without DS. The aim of this multicenter study was to shed further light on the relationships between DS and HT in childhood …
Andrew Collier, Sujoy Ghosh, Mario Hair, Iqbal Malik, Jim McGarvie
OBJECTIVE: Radioiodine therapy is the most commonly used therapy for patients with Graves’ disease (GD) in the United Kingdom. It is considered safe, effective and relatively inexpensive. The aim of our study was to examine the outcome of 131Iodine therapy in patients with GD when two different activities of 131Iodine were used …
Eugen Melcescu, William B. Horton, Karen T. Pitman, Vani Vijayakumar, Christian A. Koch
Euthyroid Graves’ orbitopathy (GO) combined with incidental papillary thyroid microcarcinoma has rarely been reported. CASE REPORT: A 61-year-old Caucasian woman initially presented with progressive fatigue, exophthalmos, and thyroid function tests within normal limits …
Rene Chee, Ravin Agah, Roberto Vita, Salvatore Benvenga
OBJECTIVE: To report a case of vaccine-induced Graves’ disease successfully managed with L-carnitine and propranolol and without antithyroid drugs (ATDs). ATDs sometimes need to be used at low doses or can be contraindicated/refused. One of the ancillary compounds available is L-carnitine …
Elena Tsourdi, Matthias Gruber, Martina Rauner, Judith Blankenburg, Tjalf Ziemssen, Lorenz C. Hofbauer
CONTEXT: Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Common adverse effects include an acute-phase reaction, infections and autoimmune diseases, including thyroid disorders …
Alfredo Campennì, Salvatore Giovinazzo, Lorenzo Curtò, Ernesto Giordano, Maria Trovato, Rosaria M. Ruggeri, Sergio Baldari
OBJECTIVE: Thyroid hemiagenesis is a rare congenital disorder characterized by the absence of a lobe and/or of isthmus. Studies on the association between thyroid hemiagenesis, Graves’ disease and differentiated thyroid cancer are rare …
Stelios Tigas, Petros Papachilleos, Nikolaos Ligkros, Maria Andrikoula, Agathocles Tsatsoulis
Glucocorticoids are commonly used in the treatment of patients with thyroid disorders, in particular Graves’ ophthalmopathy. Thyrotoxic hypokalemic periodic paralysis (TPP) is an infrequent but potentially serious condition characterised by recurrent episodes of weakness associated with hypokalemia …
Peter D. Papapetrou
According to a previously published theory, Socrates was afflicted with temporal lobe epilepsy since his childhood. Plato, Xenophon, and Aristoxenus described Socrates as having exophthalmos, probably diplopia, and some symptoms compatible with hyperthyroidism …
Sorina Martin, Anca Sirbu, Minodora Betivoiu, Suzana Florea, Carmen Barbu, Simona Fica
OBJECTIVE: Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels and the main characteristics of Graves’ disease (GD) …
Peter D. Papapetrou
Evidence is presented that the Roman emperor Maximinus Daia had Graves’ disease and died of severe thyrotoxicosis. The information about this emperor’s terminal illness is drawn from the writings of the 4th century writers Eusebius and Lactantius. An existing statue indicates that the emperor had bilateral Graves’ ophthalmopathy …