Polycystic ovary syndrome. Revised diagnostic criteria and long-term health consequences

Eleni Kousta, George Tolis, Stephen Franks

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The diagnostic criteria for polycystic ovary syndrome (PCOS) have recently been revised. The polycystic ovarian morphology has been introduced as part of the criteria and an international consensus has been achieved providing the basis for future research and collaboration. It is now accepted that polycystic ovary syndrome has important long-term health implications …

Growth hormone binding protein and acid labile subunit levels in the assessment of acromegaly treatment

Marinella Tzanela, Marieta Christoforaki, Lida Papastathopoulou, Dimitra Vassiliadi, Effie Botoula, Panagiotis Trivizas, Nikos C. Thalassinos

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Objective: Post-treatment monitoring of acromegalic patients is a matter of controversy, as discrepancies between GH and IGF-I levels have been reported. The aim of our study was to evaluate the role of acid-labile subunit (ALS), a component of the 150 kD IGF-I/IGFBP-3/ALS complex, and the growth hormone binding protein (GHBP) in the follow-up of patients with acromegaly after therapeutic intervention…

Effects of GH and IGF-I on the in vitro maturation of mouse oocytes

Erasmia Kiapekou, Dimitris Loutradis, Peter Drakakis, Evangelia Zapanti, George Mastorakos, Aristidis Antsaklis

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Objective: A number of hormones and growth factors have been reported to affect the in vitro maturation of oocytes. Their exact effects on follicular growth and oocyte maturation and the mechanisms involved are still unclear. In the present study, we have investigated the effects of Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) …

Hypoparathyroidism in a patient presenting with severe myopathy and skin rash. Case report and review of the literature

Vassiliki Syriou, Asimina Kolitsa, Lamprini Pantazi, Dimitrios Pikazis

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A 47-year old man with idiopathic hypoparathyroidism (IHP), presented as severe myopathy and skin rash is described. The serum muscle enzymes were increased. After treatment with calcium and vitamin D, the clinical condition improved, the skin rash gradually disappeared, and the muscle enzymes decreased and remained within the normal range thereafter.

A case of a prolactinoma resistant to dopamine agonists

Irene Vourliotaki, Ingrid Elizabeth Bonapart, Catherine Stamataki, Eva-Maria Tsapakis, Catherine Saridaki

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Dopamine agonists are the drugs of choice in the treatment of prolactinomas, the most common type of pituitary adenomas. However, up to 25% of prolactinomas do not respond to these drugs and alternative treatments have to be considered. We describe a 37-year old female with a microprolactinoma who, although having received all available formulations of dopamine agonists …

Hypophosphataemic osteomalacia due to de Toni-Debre-Fanconi syndrome in a 19-year old girl

Tasoula Tsilchorozidou, John G Yovos

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Osteomalacia associated with adult onset Fanconi syndrome is thought to result from hypophosphataemia due to renal phosphate loss and relative 1,25-dihydroxyvitamin D3 deficiency. In this disorder, the impaired renal phosphate uptake occurs as part of a generalized tubular defect in association with other features such as bicarbonuria, glycosuria and aminoaciduria…

On the centenary of the term

Effie Poulakou-Rebelakou, Costas Tsiamis, Spyros G. Marketos

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In June of 2005 the term hormone completed a life span of one century. The word that Ernest Henry Starling included in one of his four lectures to the Royal Society of Physicians of London, given in June 1905, definitively established the permanent representation in terminology for the products secreted by the endocrine glands…