Andrew (Andy) N. Margioris
With this first issue of HORMONES for 2013, we celebrate 12 years of continuous publication. The Journal HORMONES has been listed in Pubmed since 2005 and its current impact factor is 2.4 …
Issue 1 (January – March)121
In Remembrance of Professor Aldo Pinchera (1934-2012)
Leonidas H. Duntas
Internationally renowned Endocrinologist, Professor Aldo Pinchera, an exceptional personality and brilliant scientist, passed away on 11 October, 2012. The news of his passing was received with deep sorrow and a profound sense of loss …
From Hippocrates of Kos to Hashimoto and thyroid autoimmunity: A long road of discovery
Leonidas Duntas, Stefanos Geroulanos, Peter Laurberg
The 2012 Educational Course of the European Thyroid Association (ETA) was a truly unique event. Held 24th-26th May on the island of Kos, in the healing environment of ‘the island of Hippocrates and Asclepius’, it combined an educational level of excellence with the commemoration of the centennial of the description of Hashimoto thyroiditis …
Hashimoto’s Thyroiditis: History and Future Outlook
Yuji Hiromatsu, Hiroshi Satoh, Nobuyuki Amino
Hashimoto’s thyroiditis (HT), a common thyroid disease, is now recognized as an autoimmune thyroid disorder (AITD). However, surprisingly little is known about its discoverer, Hakaru Hashimoto, who first described the disease in 1912 …
An overview of the pathogenesis of thyroid autoimmunity
Giulia Cogni, Luca Chiovato
Autoimmune diseases are a group of heterogeneous disorders characterized by abnormal lymphocytic activation directed against self-tissues. Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are two of the most common clinical expressions of organ-specific autoimmunity …
Prevention of autoimmune hypothyroidism by modifying iodine intake and the use of tobacco and alcohol is manoeuvring between Scylla and Charybdis*
Peter Laurberg, Stig Andersen, Inge Bülow Pedersen, Nils Knudsen, Allan Carlé
Although autoimmune hypothyroidism has generally been considered to be a disease that mainly develops because of genetic aberrations and for which adjustment of environment would bring about but slight risk modification, this understanding is increasingly appearing to be incorrect …
Thyroid autoimmunity and polyglandular endocrine syndromes
Jean-Louis Wémeau, Emmanuelle Proust-Lemoine, Amélie Ryndak, Laura Vanhove
Annual increase in the frequency of papillary thyroid carcinoma as diagnosed by fine-needle aspiration at a cytology unit in Sicily
Massimo Rizzo, Alessandro Sindoni, Raffaele Talamo Rossi, Orsola Bonaffini, Stefania Panetta, Claudio Scisca, Giuseppe Altavilla, Lucia Denaro, Antonio Rosanò, Giovanna Saraceno, Francesco Trimarchi, Salvatore Benvenga
The evolution in the use of MIBG scintigraphy in pheochromocytomas and paragangliomas
Vittoria Rufini, Giorgio Treglia, Germano Perotti, Alessandro Giordano
The estrogen receptor: two or more molecules, multiple variants, diverse localizations, signaling and functions. Are we undergoing a paradigm-shift as regards their significance in breast cancer?
Marilena Kampa, Vassiliki Pelekanou, George Notas, Efstathios N. Stathopoulos, Elias Castanas
IGF-I generation test in prepubertal children with Noonan syndrome due to mutations in the PTPN11 gene
Silvano Bertelloni, Giampiero I. Baroncelli, Eleonora Dati, Silvia Ghione, Fulvia Baldinotti, Benedetta Toschi, Paolo Simi
BACKGROUND: Short stature represents one of the main features of children with Noonan syndrome. The reason for impaired growth remains largely unknown. OBJECTIVE: To assess GH and IGF1 secretion in children with Noonan syndrome …
Salivary cortisol day curves in assessing glucocorticoid replacement therapy in Addison’s disease
Lisanne Smans, Eef Lentjes, Ad Hermus, Pierre Zelissen
OBJECTIVE: Patients with Addison’s disease require lifelong treatment with glucocorticoids. At present, no glucocorticoid replacement therapy (GRT) can exactly mimic normal physiology. As a consequence, under- and especially overtreatment can occur. Suboptimal GRT may lead to various side effects …
Enhancing treatment of obesity by using a distracting mini-meal: a new approach to an old problem
Antonio Picarelli, Marco Di Tola, Fabio Tabacco, Mariacatia Marino, Raffaele Borghini, Tania D’Amico, Carla Lubrano, Patrizia Gargiulo
OBJECTIVE: The management of obesity, apart from exercise, mainly involves a calorie restriction regimen. A pharmaceutical treatment is often used to improve patient compliance and diet effectiveness, although several side-effects have previously been described …
Variations of urinary iodine during the first trimester of pregnancy in an iodine-replete area. Comparison with non-pregnant women
Atieh Amouzegar, Fereidoun Azizi
Objective: To assess variations of urinary iodine concentration (UIC) during a 4-week period among pregnant and non-pregnant women in an iodine-replete area. Design: Pregnant (in their first trimester of pregnancy) and non-pregnant women referred to two maternity hospitals in Tehran were consecutively recruited from September 2005 to March 2006 …
Adiponectin mRNA in adipose tissue and its association with metabolic risk factors in postmenopausal obese women
Sadashiv, Sunita Tiwari, Bhola Nath Paul, Sandeep Kumar, Abhijit Chandra, S. Dhananjai, Mahendra Pal Singh Negi
OBJECTIVE: The present study evaluates adiponectin mRNA in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and also evaluates its association with metabolic risk factors in postmenopausal obese women. DESIGN: A case control study was carried out on postmenopausal women …
PROP-1 gene mutations in a 63-year-old woman presenting with osteoporosis and hyperlipidaemia
Maria Andrikoula, Amalia Sertedaki, Sofia Andrikoula, Catherine Dacou-Voutetakis, Agathocles Tsatsoulis
PROP-1 gene mutations have been reported as a cause of combined pituitary hormone deficiency. Physical and hormonal phenotypes of affected individuals are variable. We report a 63-year-old female who presented with osteoporosis
Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literature
Elisa Verrua, Giovanna Mantovani, Emanuele Ferrante, Andrea Noto, Elisa Sala, Elena Malchiodi, Gaetano Iapichino, Paolo Beck-Peccoz, Anna Spada
Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction …
Maximinus Daia, a Roman emperor who may have had Graves’ disease and died of a thyrotoxic crisis
Peter D. Papapetrou
Evidence is presented that the Roman emperor Maximinus Daia had Graves’ disease and died of severe thyrotoxicosis. The information about this emperor’s terminal illness is drawn from the writings of the 4th century writers Eusebius and Lactantius. An existing statue indicates that the emperor had bilateral Graves’ ophthalmopathy …