Massimo Giusti, Francesca Cecoli, Carla Ghiara, Alessandro Rubinacci, Isabella Villa, Domenico Cavallero, Laura Mazzuoli, Michele Mussap, Roberto Lanzi, Francesco Minuto
OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), such as an in vitro action on bone, have been described. Our aim was to evaluate in vivo the acute effect of a recombinant human TSH (rhTSH)-induced TSH surge on Osteoprotegerin (OPG) and receptor activator of the nuclear factor-κB (RANK-L) levels in patients under levo-thyroxine (L-T4) therapy…