Salvatore Alesci1, Ioannis Ilias2,3, Emmanuil Souvatzoglou3, Alan G. Harris4, Philip W. Gold1, Alejandro R. Ayala3, George P. Chrousos3 1Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892-1284 USA, 2Department of Pharmacology, Medical School, University of Patras, Rion-Patras, 265 04, Greece, 3Reproductive Biology and Medicine Branch, National Institute of Child Read More
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TSH and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with L-thyroxine alone or in combination with L-triiodothyronine
Valentin V. Fadeyev, Tatiana B. Morgunova, Julia P. Sytch, Galina A. Melnichenko Department of Endocrinology of Moscow Medical Academy, Moscow, 119992, Russia Abstract The aim of this study was to evaluate parameters of thyroid function in patients with primary hypothyroidism receiving either monotherapy with L-T4 or combination L-T4+L-T3. Fifty-eight women with primary hypothyroidism receiving L-T4 Read More
Treatment of recurrent gastrointestinal haemorrhage in a patient with von Willebrand\’s disease with administration of octreotide LAR and propranolol
Napoleon Krikis, Konstantinos Tziomalos, Vasilios Perifanis, Sofia Vakalopoulou, Asterios Karagiannis, Vasilia Garypidou, Fedon Harsoulis Second Propedeutic Department of Internal Medicine, Aristotelian University of Thessaloniki, Ippokration General Hospital, Thessaloniki, Greece Abstract We report a patient with von Willebrand' s disease who had had recurrent and life-threatening bleeding from the gastrointestinal tract. Despite extensive investigation, no apparent Read More
Langerhans\’ cell histiocytosis in an adult patient manifested as recurrent skull lesions and Diabetes Insipidus
Polyzois Makras1, Dimitris Papadogias1, Chrysoula Samara2, Athanasios Zetos3, Gregory Kaltsas1, George Piaditis1, Antony C Chu 4 1Department of Endocrinology, 2Radiology, G. Genimatas General Hospital, Athens Greece; 39th Pulmonary Department, "SOTIRIA" Hospital, Athens, Greece; 4Unit of Dermatology, Royal Postgraduate Medical School, London, UK Abstract We describe a 57-year old female with the diagnosis of skull and Read More
Clinical aspects of hyperthyroidism in hospitalised patients in Albania
Feçor Agaçi Endocrinology and Diabetes Service, University Hospital Center "Mother Teresa", Tirana, Albania Abstract The purpose of this study was to evaluate certain clinical aspects of hyperthyroidism in Albania, which is an iodine deficient country, as it is known that iodine intake may influence the type of thyroid hyperfunction. The files of sixty-six patients with Read More
Increased leptin levels in preeclampsia: associations with BMI, estrogen and SHBG levels
Acromite Michael, Ziotopoulou Mary, Orlova Christine, Mantzoros Christos Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA Abstract Leptin is secreted mainly by the white adipose tissue but is also synthesized in several non-adipose tissue organs including the placenta. Serum leptin levels are increased in normal pregnancies and are higher Read More
Pegvisomant: a new treatment modality for acromegaly
Niki Karavitaki, John AH Wass Department of Endocrinology, the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK Abstract Acromegaly, a multisystemic disease resulting from excessive growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels in adults, is associated with a two-to-threefold increase in mortality. The available treatment options (surgery, radiotherapy and medical Read More
The ancient and medieval Greek writer\’s perceptions concerning the relationship between sexual characteristics and testicular volume
Athanasios Diamandopoulos, Pavlos Goudas, Demetra Patsy St. Andrew's Regional Hospital, Nephrology Unit, Patras, 263 35, Greece Physicians and scholars of antiquity were well aware that the function of the testicles of humans and animals was not restricted to the production of sperm alone but that it was directly related to sexuality and secondary sexual characteristics. Read More
Preoperative imaging and localization of small sized insulinoma with EUS-guided fine needle tattoing: a case report
George N. Zografos1, Alexandra Stathopoulou2, George Mitropapas1, John Karoubalis3, George Kontogeorgos4, Gregory Kaltsas2, George Piaditis2, George I. Papastratis1 1Third Department of Surgery, 2Department of Endocrinology, 3Department of Gastroenterology, 4Department of Pathology, Athens General Hospital, Athens, 115 27, Greece Abstract We report a case of an insulinoma that was not identified on either Computerized Tomography (CT) Read More
Reassessment of combined LT4 and LT3 treatment for hypothyroidism: the prospects for slow-release T3 preparations
Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, Athens University Medical School, Athens, 115 27, Greece "Do not draw conclusions which arise from logic alone, but also from practical demonstration"Hippocrates The introduction of synthetic levothyroxine (LT4) in the late 60's for treatment of hypothyroidism radically changed the therapeutic approach for patients with thyroid failure, enabling Read More