Maria Kalina, Barbara Kalina-Faska, Katarzyna Wojaczynska-Stanek, Ewa Malecka-Tendera, Elzbieta Marszal
Moyamoya disease is a rare cerebrovascular disorder which, according to a few literature reports, can coexist with hypothalamic-pituitary dysfunction. We report a 16 year-old boy referred to our Department because of short stature and headaches. He additionally, at admission, presented discrete facial dysmorphy, bruxism, luxation of temporomandibular joint …
Polyzois Makras, Dimitris Papadogias, Chrysoula Samara, Athanasios Zetos, Gregory Kaltsas, George Piaditis, Antony C Chu
We describe a 57-year old female with the diagnosis of skull and meningeal Langerhans’ cell histiocytosis who was treated with the combination of azathioprine and methotrexate. Although the skull lesions improved considerably on this regimen, the patient developed diabetes insipidus while the anterior pituitary function remained intact…
Yogendra S. Rajawat, Ioannis Bossis
Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins, macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis requires continuous removal of worn-out components and replacement …
Markus Eszlinger, Kurt Werner Schmid, Ralf Paschke
The evaluation of patients with nodular thyroid disease is focused on two main aspects, namely the exclusion of thyroid malignancy and the exclusion of hyperthyroidism in regions with borderline iodine supply. However, the identification and preoperative typing of both the substantially less frequently occurring thyroid carcinomas …
Pavlina D. Avgoustinaki, Effrosyni Mitsopoulou, Gregorios Chlouverakis, Theoni Triantafillou, Maria Venihaki, Sofia Koukouli, Andrew N. Margioris
OBJECTIVE: Sex steroids affect human behavior. The aim of the present study was to determine the associations, if any, between the circulating levels of gonadal and adrenal sex steroids in the mid luteal phase (21st day of a normal menstrual cycle, MC) of young professional …
Olga Karapanou, Marinella Tzanela, Nikolaos Tamouridis, Stylianos Tsagarakis
We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH …
Yueye Huang, Jiaqi Chen, Jie Yang, Kexiu Song, Xingchun Wang, Xiaoyun Cheng, Shen Qu
OBJECTIVE: Acanthosis nigricans (AN) has been closely associated with obesity. Depression has also been shown to be disproportionally prevalent among obese people. However, there is still a paucity of studies on the relationship between depressive symptoms and AN in obese patients. This study examined the difference in metabolic disorders and depressive symptoms …
Eugenia I. Marova, Nikolay P. Goncharov, Galina S. Kolesnikova, Svetlana D. Arapova, Anastasiya M. Lapshina
OBJECTIVE: The purpose of this study was to evaluate the direct action of desmopressin (agonist of vasopressin) on the hypophysis and the three zones of the adrenal cortex in patients with different forms of hypercortisolism. DESIGN: Forty-three patients with hypercortisolism—21 with Cushing’s disease (14 females, 7 males), 11 with extrapituitary …
Athina Markou, Kaity Tsigou, Dimitrios Papadogias, Kostas Kossyvakis, Kyriakos Vamvakidis, Theodora Kounadi, George Piaditis
We present a 39-year old female with a benign adrenal tumor characterized by autonomous secretion of cortisol, androgens, and aldosterone. The patient presented with a 4-year history of hypertension and severe hirsutism. Baseline investigations revealed elevated testosterone, androstendione, and 17OH progesterone with normal levels of dehydroepiandrosterone sulfate…
Katerina Saltiki, Adrianna Cimponeriu, Kyriaki Lili, Melpomeni Peppa, Eleni Anastasiou, Maria Alevizaki
Objective: Coronary artery disease (CAD) risk increases in women after the menopause. The aim of this study was to determine the effect of diabetes on the severity of CAD in postmenopausal women undergoing coronary angiography. Design: 180 postmenopausal women underwent coronary angiography for suspected CAD …
Aleksander Giwercman, Yvonne Lundberg Giwercman
An ever-increasing proportion of young males treated for cancer are cured. Therefore, one of the major challenges of modern Clinical Oncology is to ensure good quality of life. Cancer disease per se as well as cancer treatment may have a negative impact on androgen production, thereby leading to subclinical or clinically overt hypogonadism …
Valentine V. Fadeyev, Tatyana B. Morgunova, Galina A. Melnichenko, Ivan I. Dedov
Objective: The objective of this study was to compare various parameters in patients with hypothyroidism receiving either monotherapy with L-Thyroxine (L-T4) or combination therapy with L-T4 and L-Triiodothyronine (L-T3). Design: We conducted a randomized, controlled trial in 36 premenopausal women with hypothyroidism …
Polyzois Makras, Dimitris Papadogias, Grigoris Kaltsas, Nikolaos Kaklas, Georgios Piaditis
Growth without growth hormone (GH) has occasionally been described in patients with organic pituitary pathology, and even more rarely in patients with idiopathic pituitary hormone deficiency. The mechanism of growth without GH remains a mystery. We describe a 17-year old male who grew 38.5 cm in height over a 7-year period, despite the fact that he had established panhypopituitarism…
Sayer I. Al-Azzam, Karem H. Alzoubi, Omar Khabour, Ola Al-Azzeh
OBJECTIVE: To investigate the possible association between response to levothyroxine (L-T4) doses in hypothyroid patients and variation in thyroid stimulating hormone receptor (TSHR) gene and thyroid hormone receptor (THRα) gene …
Stefano Stagi, Cristina Manoni, Perla Scalini, Francesco Chiarelli, Alberto Verrotti, Cecilia Cecchi, Elisabetta Lapi, Sabrina Giglio, Silvia Romano, Maurizio de Martino
OBJECTIVE: To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS). PATIENTS: Thirty-one children (15 females, 16 males; mean age 9.6±2.74 years) and 10 young adults (6 females, 4 males; mean age 21.4±5.11 years) with WBS were cross-sectionally evaluated and compared with two age-, sex-, and body-size-matched paediatric …
Harilaos S. Vontetsianos, Spiros E. Davris, George D. Christopoulos, Catherine Dacou-Voutetakis
The effect of Adenotonsillectomy on somatic growth was studied prospectively in 57, randomly selected children (31 boys, 26 girls), aged 5.03±1.32 (mean±1SD) years. The indication for surgery was adenotonsillar hypertrophy with or without recurrent infections. Weight, height, triceps skinfold thickness, and Body Mass Index …
Maria K. Poulasouchidou, Dimitrios G. Goulis, Pavlos Poulakos, Gesthimani Mintziori, Apostolos Athanasiadis, Grigorios Grimbizis, Basil C. Tarlatzis
OBJECTIVE: To examine whether the concentrations of maternal serum TSH and free thyroxine (fT4) through pregnancy, the presence of thyroid autoimmunity (TAI) or the dose of levo-thyroxine (LT4) replacement can predict the occurrence of maternal or fetal/neonatal complications in pregnant women …
Dragan Micic, Leonidas Duntas, Goran Cvijovic, Aleksandra Kendereski, Mirjana Sumarac-Dumanovic, Peter Jehle, Svetlana Zoric, Danica Pejkovic, Mary Lague, Carlos Dieguez, Felipe Casanueva
OBJECTIVE: Ghrelin, a potent stimulator of GH secretion, also acts as an orexigenic hormone. Plasma ghrelin levels rise before meals with postprandial reduction, suggesting that circulating levels of enteroinsular hormones might influence ghrelin secretion. AIM: The aim of this study was to evaluate the effects of ghrelin on enteroinsular hormones in healthy men…
Nectaria Xita, Leandros Lazaros, Ioannis Georgiou, Agathocles Tsatsoulis
OBJECTIVE: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated-receptor-γ (PPAR-γ) has been implicated in insulin resistance and adiposity. The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism …
Hidetoshi Ikeda, Masataka Kudo
Objective: We evaluated the long-term effects of growth hormone (GH) on markers of quality of life, glucose metabolism, and lipid metabolism to validate the adequacy of long-term GH replacement therapy for adult GH deficiency (AGHD). Design: Eighty-three of 100 sequentially followed patients who received GH therapy …
Konstantinos Toulis, Paschalia Iliadou, Stylianos Mandanas, Polyzo Kazila, Efterpi Margaritidou, Konstantinos Georgopoulos, Kalliopi Pazaitou-Panayiotou
Along with achieving a reduction in the incidence of osteoporotic fractures, denosumab (a human monoclonal antibody against the receptor activator of nuclear factor kappa-B ligand (RANKL) causes conformational changes in the calcium-sensing receptor (CaSR), leading to parathyroid hormone exocytosis …
Tasoula Tsilchorozidou, John G Yovos
Osteomalacia associated with adult onset Fanconi syndrome is thought to result from hypophosphataemia due to renal phosphate loss and relative 1,25-dihydroxyvitamin D3 deficiency. In this disorder, the impaired renal phosphate uptake occurs as part of a generalized tubular defect in association with other features such as bicarbonuria, glycosuria and aminoaciduria…
Baris Akinci, Serkan Yener, Goksel Bengi, Sena Yesil
It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery…
Wei Wang, Xiaobo Yang, Jianbo Liang, Ming Liao, Haiying Zhang, Xue Qin, Linjian Mo, Wenxin Lv, Zengnan Mo
Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men …
Ioannis G Habeos, Agathoklis Psyrogiannis, Venetsana Kyriazopoulou, A Psilopanagiotou, Athanasios G Papavassiliou, Apostolos G Vagenakis
Several authors have suggested a positive association between diabetes type 2 (DM2) and the C282Y and H63D mutations of the hereditary hemochromatosis gene but others have disputed it. There are also papers reporting an increased iron load in diabetes type 2 and a possible association with the pathogenesis of the disease …