From Hippocrates of Kos to Hashimoto and thyroid autoimmunity: A long road of discovery

Leonidas Duntas, Stefanos Geroulanos, Peter Laurberg

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The 2012 Educational Course of the European Thyroid Association (ETA) was a truly unique event. Held 24th-26th May on the island of Kos, in the healing environment of ‘the island of Hippocrates and Asclepius’, it combined an educational level of excellence with the commemoration of the centennial of the description of Hashimoto thyroiditis …

Dyslipidemia in patients with thyroid disorders

Evagelos N Liberopoulos, Moses S Elisaf

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Thyroid disorders are known to influence lipid metabolism and are common in dyslipidemic patients. Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. Although thyroid substitution therapy is beneficial for patients with overt hypothyroidism …

Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis

George Carayanniotis

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Increased iodide intake has been linked to the development of hypothyroidism and/or autoimmune thyroiditis in humans and animals, but the mechanisms involved remain poorly understood. Increased ingestion of iodide is likely to have pleiotropic effects on either metabolic or immunological processes. Within the latter domain, recent interest has been focused on two areas …

Prevention of autoimmune hypothyroidism by modifying iodine intake and the use of tobacco and alcohol is manoeuvring between Scylla and Charybdis*

Peter Laurberg, Stig Andersen, Inge Bülow Pedersen, Nils Knudsen, Allan Carlé

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Although autoimmune hypothyroidism has generally been considered to be a disease that mainly develops because of genetic aberrations and for which adjustment of environment would bring about but slight risk modification, this understanding is increasingly appearing to be incorrect …

Prediction of maternal and neonatal adverse outcomes in pregnant women treated for hypothyroidism

Maria K. Poulasouchidou, Dimitrios G. Goulis, Pavlos Poulakos, Gesthimani Mintziori, Apostolos Athanasiadis, Grigorios Grimbizis, Basil C. Tarlatzis

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OBJECTIVE: To examine whether the concentrations of maternal serum TSH and free thyroxine (fT4) through pregnancy, the presence of thyroid autoimmunity (TAI) or the dose of levo-thyroxine (LT4) replacement can predict the occurrence of maternal or fetal/neonatal complications in pregnant women …

The impact of thyroid autoimmunity (TPOAb) on bone density and fracture risk in postmenopausal women

Snezana P. Polovina, Dragana Miljic, Sladjana Zivojinovic, Natasa Milic, Dragan Micic, Vera Popovic Brkic

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OBJECTIVE: Skeletal development, linear growth, cartilage biology and bone turnover are highly dependent on the activity of thyroid hormones. Thyroid dysfunction affects the skeleton, and autoimmune thyroid disease, manifesting as a chronic inflammatory condition, may be an important contributing factor to impaired bone quality in these patients. MATERIALS AND METHODS: Measurement of TSH, FT4, TPOAb and bone mineral density and FRAX score calculations were performed …