Solomis Solomou, Márta Korbonits
Ghrelin, an orexigenic protein with a unique lipid chain modification, is considered to be an important gut-brain signal for appetite control and energy balance. The ghrelin receptor, growth-hormone secretagogue receptor type 1a, is able to bind acylated ghrelin. The first recognised effect of ghrelin was the induction of growth hormone …
Grigorios Kotronoulas, Antonios Stamatakis, Fotini Stylianopoulou
Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms …
Charilaos Stylianou, Assimina Galli-Tsinopoulou, Dimitrios Farmakiotis, Israel Rousso, Michael Karamouzis, George Koliakos, Sanda Nousia-Arvanitakis
OBJECTIVE: Ghrelin and leptin levels are influenced by body fat (BF%), pubertal stage and possibly insulin resistance (IR). The aim of our study was: 1) To compare fasting ghrelin and leptin levels between obese and non-obese, adolescents, 2) to investigate possible correlations of these hormones with BF %, as well as IR…
Laura Mihalache, Andreea Gherasim, Otilia Niță, Maria Christina Ungureanu, Sergiu Serghei Pădureanu, Radu Sebastian Gavril, Lidia Iuliana Arhire
Ghrelin is a gut peptide composed of 28 amino acids mostly secreted in the gastric fundus mucosa. It was isolated and described in 1999 by Kojima et al. and only three years later its specific receptor, GHSR1a, was also identified. Ghrelin, the endogenous ligand for the GH secretagogue receptor, is the only peripheral orexigenic hormone that activates the receptors to be found especially in the appetite center (hypothalamus and pituitary gland) …
Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria G. Grammatikopoulou, George Koliakos, George Varlamis
Objective: The exact role of ghrelin in the control of growth hormone (GH) secretion has not been completely clarified as yet. The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone …
Dragan Micic, Leonidas Duntas, Goran Cvijovic, Aleksandra Kendereski, Mirjana Sumarac-Dumanovic, Peter Jehle, Svetlana Zoric, Danica Pejkovic, Mary Lague, Carlos Dieguez, Felipe Casanueva
OBJECTIVE: Ghrelin, a potent stimulator of GH secretion, also acts as an orexigenic hormone. Plasma ghrelin levels rise before meals with postprandial reduction, suggesting that circulating levels of enteroinsular hormones might influence ghrelin secretion. AIM: The aim of this study was to evaluate the effects of ghrelin on enteroinsular hormones in healthy men…