Eleni Kousta, George Tolis, Stephen Franks
The diagnostic criteria for polycystic ovary syndrome (PCOS) have recently been revised. The polycystic ovarian morphology has been introduced as part of the criteria and an international consensus has been achieved providing the basis for future research and collaboration. It is now accepted that polycystic ovary syndrome has important long-term health implications …
Paulina A. Essah, Kai I. Cheang, John E. Nestler
The polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism, and is the most common cause of anovulatory infertility in developed countries1,2. Affected women suffer not only from infertility, but also from a high rate of early pregnancy loss, defined as miscarriage during the first trimester …
Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Eleni A. Kandaraki, Ilias Katsikis
In 2007, the European Society for Human Reproduction and Embryology (ESHRE) and the American Society for Reproductive Medicine (ASRM) issued guidelines in Thessaloniki regarding the use of metformin and clomiphene for the induction of ovulation in patients with anovulatory polycystic ovary syndrome (PCOS) …
Charikleia Christakou, Anastasios Kollias, Christina Piperi, Ilias Katsikis, Dimitrios Panidis, Evanthia Diamanti-Kandarakis
OBJECTIVE: To compare the effects of oral contraceptives (OCPs) and metformin on atherogenic markers, including serum levels of advanced glycated end products (AGEs) and C-reactive protein (CRP), in lean women (Body Mass Index below 25 kg/m2) with polycystic ovary syndrome (PCOS), defined by NIH criteria …
Evangelia Tantalaki, Christina Piperi, Sarantis Livadas, Anastasios Kollias, Christos Adamopoulos, Aikaterini Koulouri, Charikleia Christakou, Evanthia Diamanti-Kandarakis
OBJECTIVE: To investigate the impact of dietary intervention on Advanced Glycation End products (AGEs) intake on the hormonal and metabolic profile in women with polycystic ovary syndrome (PCOS). METHODS: After baseline evaluation, 23 women with PCOS …
Kai I. Cheang, Paulina Essah, John E. Nestler
Current evidence suggests that insulin resistance contributes to the pathophysiologic features of the polycystic ovary syndrome (PCOS). The observation that insulin resistance is a central feature of PCOS leads to studies of the insulin signaling system in this disorder. This article reviews the possible role of putative insulin mediators, inositolphosphoglycans (IPG) mediators, in PCOS. We will focus on how IPGs mediate (a) hyperandrogenism and (b) insulin sensitivity in this disorder…
Frangiskos Economou, Xenofon Xyrafis, Sarantis Livadas, Ioannis I. Androulakis, Georgia Argyrakopoulou, Charikleia D.Christakou, Eleni Kandaraki, Eleni Palioura, Evanthia Diamanti-Kandarakis
OBJECTIVE: To investigate liver enzymes in a cohort of women with Polycystic Ovary Syndrome (PCOS) and controls divided according to body mass index (BMI) and their association with features of the syndrome. DESIGN: Eighty-three PCOS women and 64 healthy women were studied. Patients and controls were subdivided into two groups …
Ekaterini Koiou, Konstantinos Tziomalos, Ilias Katsikis, Konstantinos Dinas, Elena A. Tsourdi, Eleni A. Kandaraki, Dimitrios Delkos, Efstathios Papadakis, Dimitrios Panidis
OBJECTIVE: We aimed to assess plasma Von Willebrand factor (vWF) levels in women with polycystic ovary syndrome (PCOS) and to compare these levels among the different PCOS phenotypes. DESIGN: We studied 140 women with PCOS and 40 age and body mass index (BMI)- matched healthy women …
Ekaterini Koiou, Konstantinos Tziomalos, Ilias Katsikis, Dimitrios Delkos, Elena A. Tsourdi, Dimitrios Panidis
OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by obesity and insulin resistance (IR), which result in elevated plasminogen activator inhibitor-1 (PAI-1) levels. We aimed to assess the changes in PAI-1 levels in PCOS during treatment with metformin and during weight loss …
Olga Papalou, Sarantis Livadas, Athanasios Karachalios, Nikoleta Tolia, Panayiotis Kokkoris, Konstantinos Tripolitakis, Evanthia Diamanti-Kandarakis
Djuro Macut, Ivana Božić Antić, Jelica Bjekić-Macut, Dimitrios Panidis, Konstantinos Tziomalos, Danijela Vojnović Milutinović, Olivera Stanojlović, Biljana Kastratović-Kotlica, Milan Petakov, Nataša Milić
OBJECTIVE: There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. We aimed to determine whether LAP is associated with metabolic syndrome (MetS) in Caucasian women with PCOS …
Krystallenia Alexandraki, Athanasios D. Protogerou, Theodoros G. Papaioannou, Christina Piperi, George Mastorakos, John Lekakis, Dimitrios Panidis, Evanthia Diamanti-Kandarakis
OBJECTIVE: During the last decade cardiovascular risk factors and endothelial dysfunction have been shown to be present early in life in women with Polycystic Ovary Syndrome (PCOS). The aim of the present study was a global assessment of abnormalities in the arterial bed of young women with PCOS by non-invasive, reproducible methods…
Ana Savic-Radojevic, Ivana Bozic Antic, Vesna Coric, Jelica Bjekic-Macut, Tanja Radic, Milos Zarkovic, Tatjana Djukic, Marija Pljesa-Ercegovac, Dimitrios Panidis, Ilias Katsikis, Tatjana Simic, Djuro Macut
OBJECTIVE: In order to gain deeper insight into molecular mechanisms underlying oxidative stress (OS) and its relation to insulin resistance and hyperandrogenemia, plasma markers of OS and antioxidant glutathione-peroxidase (GPX) activity were studied in non-obese polycystic ovary syndrome (PCOS) women via the oral glucose tolerance test …
Djuro Macut, Ivana Božić Antić, Jelena Nestorov, Vladanka Topalović, Jelica Bjekić Macut, Dimitrios Panidis, Biljana Kastratović Kotlica, Efstathios Papadakis, Gordana Matić, Danijela Vojnović Milutinović
OBJECTIVE: Most women with PCOS have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevation in urinary excretion of its metabolites. Increased cortisol clearance in PCOS is followed by a compensatory overdrive of the hypothalamic-pituitary-adrenocortical (HPA) axis …
Sofia Lazaridou, Konstantinos Dinas, Konstantinos Tziomalos
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. PCOS is not only the leading cause of anovulatory infertility but is also associated with an array of metabolic disorders, among which impaired glucose metabolism has been a topic of intense research. The aim of the present narrative review is to summarize the findings of the studies that have evaluated the prevalence and incidence of prediabetes and type 2 diabetes mellitus …
Nectaria Xita, Leandros Lazaros, Ioannis Georgiou, Agathocles Tsatsoulis
OBJECTIVE: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated-receptor-γ (PPAR-γ) has been implicated in insulin resistance and adiposity. The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism …
Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Panagiotis Chatzis, Eleni A. Kandaraki, Elena A. Tsourdi, Djuro Macut, Jelica Bjekic-Macut, Apostolos Marthopoulos, Ilias Katsikis
OBJECTIVE: Limited data suggest that menstrual cycle abnormalities are more pronounced in younger and more obese patients with polycystic ovary syndrome (PCOS). We aimed to evaluate the association between menstrual cycle pattern and age, obesity and PCOS phenotype in a large population of women with PCOS …