Tag: Polycystic ovary syndrome
Polycystic ovary syndrome. Revised diagnostic criteria and long-term health consequences
Eleni Kousta, George Tolis, Stephen Franks
The diagnostic criteria for polycystic ovary syndrome (PCOS) have recently been revised. The polycystic ovarian morphology has been introduced as part of the criteria and an international consensus has been achieved providing the basis for future research and collaboration. It is now accepted that polycystic ovary syndrome has important long-term health implications …
The Pathophysiology of Miscarriage in Women with Polycystic Ovary Syndrome. Review and Proposed Hypothesis of Mechanisms Involved
Paulina A. Essah, Kai I. Cheang, John E. Nestler
The polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism, and is the most common cause of anovulatory infertility in developed countries1,2. Affected women suffer not only from infertility, but also from a high rate of early pregnancy loss, defined as miscarriage during the first trimester …
A Paradox: The Roles of Inositolphosphoglycans in mediating insulin sensitivity and Hyperandrogenism in the Polycystic Ovary Syndrome
Kai I. Cheang, Paulina Essah, John E. Nestler
Current evidence suggests that insulin resistance contributes to the pathophysiologic features of the polycystic ovary syndrome (PCOS). The observation that insulin resistance is a central feature of PCOS leads to studies of the insulin signaling system in this disorder. This article reviews the possible role of putative insulin mediators, inositolphosphoglycans (IPG) mediators, in PCOS. We will focus on how IPGs mediate (a) hyperandrogenism and (b) insulin sensitivity in this disorder…
Early microvascular and macrovascular dysfunction is not accompanied by structural arterial injury in polycystic ovary syndrome
Krystallenia Alexandraki, Athanasios D. Protogerou, Theodoros G. Papaioannou, Christina Piperi, George Mastorakos, John Lekakis, Dimitrios Panidis, Evanthia Diamanti-Kandarakis
OBJECTIVE: During the last decade cardiovascular risk factors and endothelial dysfunction have been shown to be present early in life in women with Polycystic Ovary Syndrome (PCOS). The aim of the present study was a global assessment of abnormalities in the arterial bed of young women with PCOS by non-invasive, reproducible methods…