Andrzej Bartke, Michael Bonkowski, Michal Masternak
In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous mutations or targeted disruption of GH- or IGF1-related genes can lead to an impressive increase of longevity…
Tag: Lifespan
The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
Zvi Laron
Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man…
Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)
Ilpo Huhtaniemi, Juuso I. Mäkinen, Antti Perheentupa, Olli T. Raitakari
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Interest has arisen during the last 10 years as to the possible connection between the age-related decline in androgen production and symptoms of ageing in men. A new ageing-related syndrome with several descriptive names …
Autophagy in aging and in neurodegenerative disorders
Yogendra S. Rajawat, Ioannis Bossis
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Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins, macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis requires continuous removal of worn-out components and replacement …
The length of life and eugeria in classical Greece
Menelaos L. Batrinos
Contrary to the commonly held belief that in antiquity and as late as 1700 A.D. normal lifespan was about 35 years, there are indications that the ancient Greeks lived longer. In a study of all men of renown, living in the 5th and 4th century in Greece …