The Pro12Ala polymorphism of the PPAR-γ gene is not associated with the polycystic ovary syndrome

Nectaria Xita, Leandros Lazaros, Ioannis Georgiou, Agathocles Tsatsoulis

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OBJECTIVE: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated-receptor-γ (PPAR-γ) has been implicated in insulin resistance and adiposity. The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism …