Valentine V. Fadeyev, Tatyana B. Morgunova, Galina A. Melnichenko, Ivan I. Dedov
Objective: The objective of this study was to compare various parameters in patients with hypothyroidism receiving either monotherapy with L-Thyroxine (L-T4) or combination therapy with L-T4 and L-Triiodothyronine (L-T3). Design: We conducted a randomized, controlled trial in 36 premenopausal women with hypothyroidism …
Sayer I. Al-Azzam, Karem H. Alzoubi, Omar Khabour, Ola Al-Azzeh
OBJECTIVE: To investigate the possible association between response to levothyroxine (L-T4) doses in hypothyroid patients and variation in thyroid stimulating hormone receptor (TSHR) gene and thyroid hormone receptor (THRα) gene …
Baris Akinci, Abdurrahman Comlekci, Serkan Yener, Tevfik Demir, Firat Bayraktar, Faize Yuksel, Sena Yesil
OBJECTIVE: There is controversy as to whether hypothyroidism increases cardiovascular risk. The effect of levothyroxine on the cardiovascular risk profile is also unclear. Recent studies suggest that there is evidence of inflammation and endothelial dysfunction in hypothyroidism. Soluble CD40 ligand (sCD40L) is a protein expressed mainly by activated platelets …