Tag: osteoporosis
Depression and Osteoporosis in Men: Association or Casual Link?
Ioannis Ilias, Salvatore Alesci, Philip W. Gold, George P. Chrousos
The longer life expectancy of women than that of men and, therefore, the longer exposure to fracture risk has, at least partially, led to neglect of osteoporosis in men. Recently, unipolar depression, which is 2 times more frequent in women than in men, has been linked to osteoporosis…
Weightlessness and skeleton homeostasis
Konstantinos Ziambaras, Roberto Civitelli, Stathis S. Papavasiliou
As human beings venture into space in the 21st century, they will be confronted with a “hypodynamic” and thus hostile environment for the bone homeostasis, that could potentially compromise their mobility in general and skeletal strength in particular after landing. From this point of view, space flight studies are especially interesting and intriguing models for scientists…
Glucocorticoids and bone: cellular, metabolic and endocrine effects
Mauro Doga, Stefania Bonadonna, Andrea Giustina
Chronic exposure to excessive concentrations of endogenous cortisol or to pharmacologic doses of glucocorticoids (GCs) causes multiple deleterious effects on body structure and function. Osteopenia, osteoporosis and bone fractures are well recognized consequences of excessive GC exposure, with fractures being a major cause of morbidity and mortality, particularly in the elderly. In particular, GCs have profound effects on bone metabolism, acting at many sites…
Subclinical hyperthyroidism of variable etiology and its influence on bone in postmenopausal women
Zhanna E. Belaya, Galina A. Melnichenko, Ljudmila Y. Rozhinskaya, Valentin V. Fadeev, Tatjana M. Alekseeva, Olga K. Dorofeeva, Natalja I. Sasonova, Galina S. Kolesnikova
OBJECTIVE: To evaluate the effects of subclinical hyperthyroidism of variable etiology on bone mineral density (BMD) and bone metabolism in postmenopausal women. DESIGN: T he study included data of 88 postmenopausal women classified into four groups depending on the etiology of subclinical hyperthyroidism: (1) 20 with toxic multinodular goiter without history of clinical hyperthyroidism …
Oral bisphosphonate adverse effects in 849 patients with metabolic bone diseases
Athanasios D. Anastasilakis, Dimitrios G. Goulis, Marina Kita, Avraam Avramidis
OBJECTIVE: Bisphosphonates are potent antiresorptive agents used for a spectrum of metabolic bone diseases. The aim of this study was to compare the adverse effects (AEs) of alendronate, etidronate and risedronate prescribed in a non-selected population, attending a single institution on an outpatient basis…