Olga Karapanou, Marinella Tzanela, Nikolaos Tamouridis, Stylianos Tsagarakis
We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH …
Tasoula Tsilchorozidou, John G Yovos
Osteomalacia associated with adult onset Fanconi syndrome is thought to result from hypophosphataemia due to renal phosphate loss and relative 1,25-dihydroxyvitamin D3 deficiency. In this disorder, the impaired renal phosphate uptake occurs as part of a generalized tubular defect in association with other features such as bicarbonuria, glycosuria and aminoaciduria…
Maria K. Poulasouchidou, Dimitrios G. Goulis, Pavlos Poulakos, Gesthimani Mintziori, Apostolos Athanasiadis, Grigorios Grimbizis, Basil C. Tarlatzis
OBJECTIVE: To examine whether the concentrations of maternal serum TSH and free thyroxine (fT4) through pregnancy, the presence of thyroid autoimmunity (TAI) or the dose of levo-thyroxine (LT4) replacement can predict the occurrence of maternal or fetal/neonatal complications in pregnant women …
Sotirios Bethanis, George Koutsodontis, Theodosia Palouka, Christos Avgoustis, Drakoulis Yannoukakos, Thalia Bei, Savas Papadopoulos, Dimitrios Linos, Stylianos Tsagarakis
Multiple endocrine neoplasia type 2A (MEN2A) is a syndrome of familial neoplasias characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and hyperplasia of the parathyroid glands. RET protooncogene mutations are responsible for MEN 2A. Mutations in exons 10 or 11 have been identified in more than 96% of patients with MEN 2A…
Anastasios Papadimitriou, Ioanna Fountzoula, Georgia Tzortzatou, Himangshu S. Bose
We present a female patient who, at the age of 35 days, presented with adrenal insufficiency with salt loss. Clinical and endocrinological investigation (low to normal levels of all adrenal steroids and raised ACTH) and imaging studies suggested congenital lipoid adrenal hyperplasia …
Athina Markou, Kaity Tsigou, Dimitrios Papadogias, Kostas Kossyvakis, Kyriakos Vamvakidis, Theodora Kounadi, George Piaditis
We present a 39-year old female with a benign adrenal tumor characterized by autonomous secretion of cortisol, androgens, and aldosterone. The patient presented with a 4-year history of hypertension and severe hirsutism. Baseline investigations revealed elevated testosterone, androstendione, and 17OH progesterone with normal levels of dehydroepiandrosterone sulfate…
Fabio Rotondo, Antonio Di Ieva, Kalman Kovacs, Michael D. Cusimano, Luis V. Syro, Eleftherios P. Diamandis, George M. Yousef
OBJECTIVE: Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors …
Christos Maniotis, Klio Chantziara, Panagiotis Kokkoris, Dimitrios Papadogiannis, Constantinos Andreou, Constantinos Tsioufis, Georgios Vaiopoulos, Christodoulos Stefanadis
OBJECTIVE: This study surveyed the frequencies of single nucleotide polymorphisms (SNPs) M235T AGT and C825T GNB3, and their association with insulin resistance, other biochemical markers and qualitative variables in subjects with high normal blood pressure and/or prehypertension in the Greek population …
Eugenia I. Marova, Nikolay P. Goncharov, Galina S. Kolesnikova, Svetlana D. Arapova, Anastasiya M. Lapshina
OBJECTIVE: The purpose of this study was to evaluate the direct action of desmopressin (agonist of vasopressin) on the hypophysis and the three zones of the adrenal cortex in patients with different forms of hypercortisolism. DESIGN: Forty-three patients with hypercortisolism—21 with Cushing’s disease (14 females, 7 males), 11 with extrapituitary …
Eleni Thodou, Theodore Argyrakos, George Kontogeorgos
OBJECTIVE: Galectin-3 (Gal-3) belongs to the family of carbohydrate-binding proteins with high affinity for galactoside and is involved in many biological processes including cell growth and differentiation, cell adhesion, tumor progression, apoptosis and metastasis. The aim of this study was to disclose differences in the expression of Gal-3 in silent …
Maria Hassapidou, Sousana K. Papadopoulou, Athanasios Frossinis, Ioannis Kaklamanos, Themistoklis Tzotzas
OBJECTIVE: To investigate sociodemographic, ethnic and dietary factors associated with the development of childhood obesity. DESIGN: 276 children, aged 8-12 years, randomly selected from seven schools in Thessaloniki, Northern Greece, participated in the study. 13% of the children were immigrants from neighboring Balkan countries and ex-Soviet Union countries …
Cenk Aral, Mustafa Akkiprik, Sinan Caglayan, Zehra Atabey, Gokhan Ozişik, Nuray Bekiroglu, Ayşe Ozer
OBJECTIVE: Mitochondrial DNA (mtDNA) polymorphisms have been implicated in the pathophysiology of human diseases. Among them, a T>C nucleotide transition on the 16189 nucleotide position of mtDNA has been studied in several metabolic diseases including diabetes and obesity. In this study we aimed to investigate the association of this polymorphism …
Monica Livia Gheorghiu, Simona Găloiu, Mădălina Vintilă, Mariana Purice, Dan Hortopan, Anda Dumitraşcu, Mihail Coculescu, Cătălina Poiană
BACKGROUND: Somatostatin analogs (SSA) are now considered standard therapy for acromegaly, as primary or adjunctive treatment after pituitary surgery. OBJECTIVE: To evaluate the efficacy of SSA and the effect of dose escalation in non-operated patients with acromegaly as compared to patients treated after pituitary surgery in a Romanian tertiary care center …
Baris Akinci, Serkan Yener, Goksel Bengi, Sena Yesil
It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery…
Dragan Micic, Leonidas Duntas, Goran Cvijovic, Aleksandra Kendereski, Mirjana Sumarac-Dumanovic, Peter Jehle, Svetlana Zoric, Danica Pejkovic, Mary Lague, Carlos Dieguez, Felipe Casanueva
OBJECTIVE: Ghrelin, a potent stimulator of GH secretion, also acts as an orexigenic hormone. Plasma ghrelin levels rise before meals with postprandial reduction, suggesting that circulating levels of enteroinsular hormones might influence ghrelin secretion. AIM: The aim of this study was to evaluate the effects of ghrelin on enteroinsular hormones in healthy men…
Hidetoshi Ikeda, Masataka Kudo
Objective: We evaluated the long-term effects of growth hormone (GH) on markers of quality of life, glucose metabolism, and lipid metabolism to validate the adequacy of long-term GH replacement therapy for adult GH deficiency (AGHD). Design: Eighty-three of 100 sequentially followed patients who received GH therapy …
Harilaos S. Vontetsianos, Spiros E. Davris, George D. Christopoulos, Catherine Dacou-Voutetakis
The effect of Adenotonsillectomy on somatic growth was studied prospectively in 57, randomly selected children (31 boys, 26 girls), aged 5.03±1.32 (mean±1SD) years. The indication for surgery was adenotonsillar hypertrophy with or without recurrent infections. Weight, height, triceps skinfold thickness, and Body Mass Index …
Wei Wang, Xiaobo Yang, Jianbo Liang, Ming Liao, Haiying Zhang, Xue Qin, Linjian Mo, Wenxin Lv, Zengnan Mo
Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men …
Pavlina D. Avgoustinaki, Effrosyni Mitsopoulou, Gregorios Chlouverakis, Theoni Triantafillou, Maria Venihaki, Sofia Koukouli, Andrew N. Margioris
OBJECTIVE: Sex steroids affect human behavior. The aim of the present study was to determine the associations, if any, between the circulating levels of gonadal and adrenal sex steroids in the mid luteal phase (21st day of a normal menstrual cycle, MC) of young professional …
Sandra Pekic, Mirjana Doknic, Marina Djurovic, Svetozar Damjanovic, Milan Petakov1 Dragana Miljic, Carlos Dieguez, Felipe F Casanueva, Vera Popovic
The aim of this study was to evaluate the influence of circulating cortisol levels on the somatotroph responsiveness to the most potent stimuli of growth hormone (GH) secretion, the GHRH+GHRP-6 test. We studied 12 patients with hypocortisolism (10 with Addison’s disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared …
Nicos Skordis, Elisavet Efstathiou, Tassos C. Kyriakides, Antria Savvidou, Savvas C. Savva, Leonidas A. Phylactou, Christos Shammas, Vassos Neocleous
OBJECTIVE: The incidence of Type 1 diabetes mellitus (T1DM) in Greek-Cypriot children aged less than 15 years between 1990 and 2009 was examined along with gender differences concerning the age of onset and the seasonal variation at manifestation of the disease …
Maria Kalina, Barbara Kalina-Faska, Katarzyna Wojaczynska-Stanek, Ewa Malecka-Tendera, Elzbieta Marszal
Moyamoya disease is a rare cerebrovascular disorder which, according to a few literature reports, can coexist with hypothalamic-pituitary dysfunction. We report a 16 year-old boy referred to our Department because of short stature and headaches. He additionally, at admission, presented discrete facial dysmorphy, bruxism, luxation of temporomandibular joint …
Kyriaki Karavanaki, Andriani Divoli, Mehul Dattani, George Briassoulis, Virginia Theodorou, Vasiliki Hatzara, Spyros Avlonitis
A 6-year old girl was examined having two years previously presented a transient Cushing’s syndrome, followed by recurrent hyponatremia, attributed to inappropriate ADH secretion (SIADH). The brain MRI showed no abnormalities on repeated examinations, except for a suggestion of empty sella syndrome. During the past two years she also presented recurrent episodes of a prolonged febrile illness of unknown origin…
Nicos Skordis, Christos Shammas, Elisavet Efstathiou, Amalia Sertedaki, Vassos Neocleous, Leonidas Phylactou
BACKGROUND: The clinical spectrum of 5α-reductase deficiency, caused by mutations in the SRD5A2 gene, ranges from complete female appearance of the external genitalia at birth to nearly complete male phenotype. CASE REPORT: A 14-year-old girl presented with primary amenorrhea (PA) and lack of breast development …
Polyzois Makras, Dimitris Papadogias, Grigoris Kaltsas, Nikolaos Kaklas, Georgios Piaditis
Growth without growth hormone (GH) has occasionally been described in patients with organic pituitary pathology, and even more rarely in patients with idiopathic pituitary hormone deficiency. The mechanism of growth without GH remains a mystery. We describe a 17-year old male who grew 38.5 cm in height over a 7-year period, despite the fact that he had established panhypopituitarism…