Irene Vourliotaki1, Ingrid Elizabeth Bonapart1, Catherine Stamataki1, Eva-Maria Tsapakis2, Catherine Saridaki1 1Department of Endocrinology and Metabolism, Venizelio General Hospital, Iraklion, Crete, Greece, 2Institute of Psychiatry, London, UK Abstract Dopamine agonists are the drugs of choice in the treatment of prolactinomas, the most common type of pituitary adenomas. However, up to 25% of prolactinomas do not Read More
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Hypophosphataemic osteomalacia due to de Toni-Debre-Fanconi syndrome in a 19-year old girl
Tasoula Tsilchorozidou, John G Yovos Division of Endocrinology, Diabetes and Metabolism, AHEPA University Hospital, Thessaloniki, Greece Abstract Osteomalacia associated with adult onset Fanconi syndrome is thought to result from hypophosphataemia due to renal phosphate loss and relative 1,25-dihydroxyvitamin D3 deficiency. In this disorder, the impaired renal phosphate uptake occurs as part of a generalized tubular Read More
Pegvisomant: a new treatment modality for acromegaly
Niki Karavitaki, John AH Wass Department of Endocrinology, the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK Abstract Acromegaly, a multisystemic disease resulting from excessive growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels in adults, is associated with a two-to-threefold increase in mortality. The available treatment options (surgery, radiotherapy and medical Read More
The ancient and medieval Greek writer\’s perceptions concerning the relationship between sexual characteristics and testicular volume
Athanasios Diamandopoulos, Pavlos Goudas, Demetra Patsy St. Andrew's Regional Hospital, Nephrology Unit, Patras, 263 35, Greece Physicians and scholars of antiquity were well aware that the function of the testicles of humans and animals was not restricted to the production of sperm alone but that it was directly related to sexuality and secondary sexual characteristics. Read More
Preoperative imaging and localization of small sized insulinoma with EUS-guided fine needle tattoing: a case report
George N. Zografos1, Alexandra Stathopoulou2, George Mitropapas1, John Karoubalis3, George Kontogeorgos4, Gregory Kaltsas2, George Piaditis2, George I. Papastratis1 1Third Department of Surgery, 2Department of Endocrinology, 3Department of Gastroenterology, 4Department of Pathology, Athens General Hospital, Athens, 115 27, Greece Abstract We report a case of an insulinoma that was not identified on either Computerized Tomography (CT) Read More
Reassessment of combined LT4 and LT3 treatment for hypothyroidism: the prospects for slow-release T3 preparations
Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, Athens University Medical School, Athens, 115 27, Greece "Do not draw conclusions which arise from logic alone, but also from practical demonstration"Hippocrates The introduction of synthetic levothyroxine (LT4) in the late 60's for treatment of hypothyroidism radically changed the therapeutic approach for patients with thyroid failure, enabling Read More
TSH and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with L-thyroxine alone or in combination with L-triiodothyronine
Valentin V. Fadeyev, Tatiana B. Morgunova, Julia P. Sytch, Galina A. Melnichenko Department of Endocrinology of Moscow Medical Academy, Moscow, 119992, Russia Abstract The aim of this study was to evaluate parameters of thyroid function in patients with primary hypothyroidism receiving either monotherapy with L-T4 or combination L-T4+L-T3. Fifty-eight women with primary hypothyroidism receiving L-T4 Read More
Intramuscular administration of ACTH1-24 vs. 24-hour blood sampling in the assessment of adrenocortical function
Salvatore Alesci1, Ioannis Ilias2,3, Emmanuil Souvatzoglou3, Alan G. Harris4, Philip W. Gold1, Alejandro R. Ayala3, George P. Chrousos3 1Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892-1284 USA, 2Department of Pharmacology, Medical School, University of Patras, Rion-Patras, 265 04, Greece, 3Reproductive Biology and Medicine Branch, National Institute of Child Read More
Obesity and renal disease: A possible role of leptin
Dafni-Kalliopi Papafragkaki1, George Tolis2 1Department of Internal Medicine Advocate Illinois Masonic Medical Center, Chicago, IL, 60657, USA, 2Division of Endocrinology and Metabolism Hippokrateion Hospital, Athens, 115 27, Greece Abstract Obesity is one of the most frequently encountered medical problems of our time. Among the complications of this pathologic entity, renal disease is an important issue Read More
On the centenary of the term
Effie Poulakou-Rebelakou, Costas Tsiamis, Spyros G. Marketos History of Medicine, Athens University, Medical School INTRODUCTION In June of 2005 the term hormone completed a life span of one century. The word that Ernest Henry Starling included in one of his four lectures to the Royal Society of Physicians of London, given in June 1905, definitively Read More