Testicular leydig cell tumor presenting as primary infertility

Athina Markou1, Justin Vale2, Bhumita Vadgama1, Marjori Walker2, Stephen Franks1 1Department of Reproductive Science and Medicine, Imperial College Faculty of Medicine, 2St Mary’s Hospital, London Abstract A 29-year old male and his wife presented with an 18 month history of primary infertility. History and initial investigations suggested no major female pathologic component but a semen Read More

Secular growth changes in the Hellenic population in the twentieth century

Anastasios Papadimitriou1, Dimitrios Chiotis2, Georgios Tsiftis2, Maria Hatzisimeon2, Maria Maniati2, Xenofon Krikos2, Anastasia Tzonou3, Catherine Dacou-Voutetakis2 1Penteli Children’s Hospital, 2Endocrine Unit, First Dept of Pediatrics, Athens University Medical School, 3Dept of Hygiene Epidemiology, Athens University Medical School, Athens, Greece Download PDF Address correspondence and requests for reprints to: C. Dacou-Voutetakis, Agia Sophia Children’s Hosp. Goudi Read More

Continuous combined replacement therapy in postmenopausal women: effect on plasma lipoproteins, bone mass and the endometrium

Odysseas Gregoriou,George Christodoulakos, Charalambos Siristatidis, Socrates Conidaris, Evangelia Kouskouni, George Creatsas 2nd Department of Obstetrics and Gynaecology, Aretaieion Hospital, University of Athens Medical School, Athens, Greece Abstract Objective: The purpose of this study was to examine the effects of Hormone Replacement Therapy (HRT) on plasma lipoprotein levels, bone mass and the endometrium. Methods: Thirty healthy Read More

Glucocortidoid sensitivity assessed in peripheral blood cells do not correlate with the feedback sensitivity of the hypothalamo-pituitary adrenal AXIS

Dimitra Vasiliadi1, Yannis Gratsias2, Stylianos Tsagarakis1, Eythimia Botoula1, Panagiotis Trivizas1, Nick Thalassinos1, Paraskevi Moutsatsou2 1Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital and 2Department of Biochemistry, Athens University Medical School Abstract Glucocorticoids (GC) affect virtually all organ systems, acting mainly via the glucocorticoid receptor (GR). The immune system is the best characterized tissue for assessing Read More

Structure-function relationships of glycoprotein hormones; lessons from mutations and polymorphisms of the thyrotrophin and gonadotrophin subunit genes

Maria Alevizaki1, Ilpo Huhtaniemi2 1Endocrine Unit, Department of Medical Therapeutics, Athens University School of Medicine, Athens, Greece, and 2Institute of Reproductive and Developmental Biology, Imperial College Medical Faculty, London, U.K. Abstract The pituitary glycoprotein hormones thyrotrophin (thyroid-stimulating hormone, TSH), lutrophin (luteinising hormone, LH) and follitrophin (follicle-stimulating hormone, FSH), as well as the placental choriongonadotrophin (human Read More

Dyslipidemia in patients with thyroid disorders

Evagelos N Liberopoulos, Moses S Elisaf Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece Abstract Thyroid disorders are known to influence lipid metabolism and are common in dyslipidemic patients. Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. Although Read More

Leptin, nutrition and reproduction: new insights

Vera Popovic1, Felipe F. Casanueva2 1Institute of Endocrinology,Diabetes and Metabolic Diseases, University Clinical Center, Belgrade, Serbia and 2Department of Medicine, Endocrinology Section, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain Abstract Recent data suggest that in addition to leptin’s role in conveying signals of the amount of energy stores to the central nervous system, Read More

Pitutaty insufficiency. Diagnosis masked by a toxic thyroid adenoma

Maria Alevizaki1,2, Lia-Angela Moulopoulos3, Emily Mantzos1, Demetrios A. Koutras1,2 Endocrine Units, “Evgenidion” Hospital1, Department of Clinical Therapeutics2, ALEXANDRA Hospital, and 3Dept of Roentgenology, Athens University School of Medicine, 11528 Athens, Greece Abstract A patient with undiagnosed pituitary insufficiency who also had a toxic thyroid adenoma is presented. The T3 secreted by the adenoma apparently corrected Read More

β-thalassemia and gonadal axis: a cross-sectional, clinical study in a Greek population

John Papadimas, Dimitrios G. Goulis, Eudokia Mandala, George Georgiadis, Vassiliki Zournatzi, Basil C. Tarlatzis, John N. Bontis Unit of Reproductive Endocrinology, 1st Department of Obstetrics & Gynecology, Hippocration General Hospital, Aristotle University of Thessaloniki, 546 42 Thessaloniki, Greece Abstract β-thalassemia (β-thal) is characterized by disturbances of the reproductive system. The aim of the present study Read More