Category: Volume 1 (2002)
Pseudohypoparathyroidism type Ia and growth hormone deficiency. Growth hormone releasing hormone receptor defect?
Fotini Psychou, Polyxeni Nicolaidou, Helen Georgouli, Maria Maniati-Christidis, Catherine Dacou-Voutetakis
We report a boy with pseudohypoparathyroidism (PHP), hypothyroidism and low growth hormone (GH) values with no response to growth hormone releasing hormone (GHRH). He presented at age 17 mo because of developmental delay. He had the typical features (short stature, obesity, round face, brachydactyly) of Albright’s hereditary osteodystrophy (AHO) …
A somatic mutation in the thyrotropin receptor gene in a patient with an autonomous nodule within a multinodular goiter
Gerasimos P. Sykiotis, Argyro Sgourou, Adamantia Papachatzopoulou, Kostas B. Markou, Venetsana Kyriazopoulou, Athanasios G. Papavassiliou, Apostolos G. Vagenakis, Neoklis A. Georgopoulos
Thyrotropin (TSH) is the prime regulator of thyroid cell growth and function and acts through the thyrotropin receptor (TSHR) located on the surface membrane of thyrocytes. Somatic heterozygous mutations that cause TSHR activation in the absence of TSH have been found in toxic adenomas and in hot nodules of multinodular goiters…
Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis.
Nicholas J. Sarlis, Loukas Gourgiotis, Frank Pucino, George J. Tolis
Several authors have suggested a positive association between Hashimoto thyroiditis (HT) and breast cancer (BrCa). Others have refuted these findings; hence, this subject remains controversial. We therefore reviewed the world literature on this subject accumulated over the last 50 years and performed a quantitative research synthesis …
The Calcium-Sensing Receptor (CaR) and its Disorders
Edward M. Brown
The system that regulates extracellular calcium (Ca2+o) homeostasis maintains a nearly constant level of Ca2+o so as to ensure the availability of calcium for its numerous intra- and extracellular roles. The molecular cloning and characterization of a G protein-coupled, Ca2+o-sensing receptor has elucidated the mechanism through which parathyroid cells …
Sodium Iodide Symporter (NIS) and Thyroid
Christine Spitzweg, John C. Morris
Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the biosynthesis of thyroid hormones which play an important role in the metabolism, growth and maturation of a variety of organ systems, in particular the nervous system1. Although, iodide transport into the thyroid gland has been known …
Compensatory adrenal growth in relation to stress of surgery and estradiol in adult male rats
Nicholas Bikas, Joan Gribisi, Joan Messari and Anastasia Sfikakis
ACTH infusion at the time of unilateral adrenalectomy inhibits the early rapid compensatory growth (CAG) in the remaining adrenal. We examined the hypothesis that different duration of surgery and/or the enhanced response to the stress of surgery, induced by estradiol treatment, might modify CAG. Adult male rats untreated …