Antje Körner, Susann Blüher, Thomas Kapellen, Ante Garten, Jürgen Klammt, Jürgen Kratzsch, Wieland Kiess
Body weight is regulated by a feedback loop in which peripheral signals report nutritional information to an integratory center in the brain. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centered in the hypothalamus…